Entry
Name
ABC-type ferric hydroxamate transporter;
iron(III) hydroxamate transporting ATPase;
iron(III) hydroxamate ABC transporter;
fhuCDB (gene names)
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase [ABC-type, iron(III) hydroxamate-importing]
Reaction(IUBMB)
ATP + H2O + Fe3+-hydroxamate complex-[hydroxamate-binding protein][side 1] = ADP + phosphate + Fe3+-hydroxamate complex[side 2] + [hydroxamate-binding protein][side 1]
Substrate
ATP [CPD:
C00002 ];
H2O [CPD:
C00001 ];
Fe3+-hydroxamate complex-[hydroxamate-binding protein][side 1]
Product
ADP [CPD:
C00008 ];
phosphate [CPD:
C00009 ];
Fe3+-hydroxamate complex[side 2];
[hydroxamate-binding protein][side 1]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of Fe3+-complexed hydroxamate siderophores such as coprogen, ferrichrome and the ferric hydroxamate antibiotic, albomycin.
History
EC 7.2.2.16 created 2000 as EC 3.6.3.34, part transferred 2018 to EC 7.2.2.16
Orthology
K10829 ferric hydroxamate transport system ATP-binding protein
K25290 ferric hydroxamate/heme transport system ATP-binding protein
Genes
ECOO : ECRM13514_0158(fhuC)
ECOH : ECRM13516_0161(fhuC)
ECW : EcE24377A_0156(fhuC)
EDJ : ECDH1ME8569_0145(fhuC)
ECOI : ECOPMV1_00157(fhuC_1)
REE : electrica_04181(fhuC_3)
RTG : NCTC13098_06103(fhuC_2)
CLAP : NCTC11466_03777(fhuC_2)
KOB : HF650_04505(fhuC) HF650_07895
KIE : NCTC12125_02880(fhuC_2)
AHN : NCTC12129_00943(fhuC_1)
YPG : YpAngola_A0998(fhuC)
YPI : YpsIP31758_3333(fhuC)
SMW : SMWW4_v1c40880(fhuC)
SFJ : SAMEA4384070_4098(fhuC_3)
SOF : NCTC11214_02647(fhuC_2)
SGRI : SGBXF1_04078(fhuC_2)
SSAR : SSARUM_003978(fhuC)
PARL : PEC302110_29030(fhuC)
TPTY : NCTC11468_01846(fhuC_1)
PHEI : NCTC12003_02406(fhuC_1)
HIC : NTHIC486_00316(fhuC_1)
ALIG : NCTC10568_02411(fhuC)
AVT : NCTC3438_01815(fhuC_2)
RPNE : NCTC8284_02544(fecE_2)
PAET : NCTC13378_00853(fecE)
VEX : VEA_001283 VEA_003570
VDB : AL552_04665 AL552_16575
VFU : vfu_A00214 vfu_B00458
VAU : VANGNB10_cI2589c(fhuB)
VCY : IX92_07940 IX92_17030
VCT : JV59_21995 JV59_30590
VTU : IX91_18700 IX91_22845
VEU : IXK98_00825 IXK98_04925
VMI : AL543_10100 AL543_14525
VTA : A2100(fhuC) B0968(fhuC)
VNL : D3H41_07195 D3H41_24105
VCC : FAZ90_08105 FAZ90_20585
VKA : BTD91_15915 BTD91_19030
VGI : MID13_07365 MID13_20725
VSL : LTQ54_03760 LTQ54_19560
VPL : SA104470976_02542(fhuB_2)
VPG : LZI70_18845 LZI70_19450 LZI70_20490
VOS : KNV97_09590 KNV97_18205
VLE : ISX51_12085 ISX51_14560 ISX51_17730
VSY : K08M4_20140(fhuC_2) K08M4_34650(fhuC_3)
VMT : QYQ96_04715 QYQ96_12825
VIB : VspSTUT11_37000 VspSTUT11_38870(fhuC)
VIS : VspSTUT16_14930 VspSTUT16_36580
VFI : VF_A0158(fhuC) VF_A0783
VFM : VFMJ11_A0194 VFMJ11_A0908
VSA : VSAL_II0150 VSAL_II0908(hatC)
PSLP : BHQ29_03000 BHQ29_07970
PKH : JLK41_16395 JLK41_20915
PHF : NLY38_08630 NLY38_21275
PCHE : QYM18_03480 QYM18_22875
MNK : RE428_02540 RE428_35800
PALI : A3K91_1217 A3K91_1565
PSYP : E5677_05560 E5677_07325
MCUN : NCTC10297_01666(fhuC_2)
MOW : RNZ41_09840 RNZ41_10815
MVS : MVIS_0626(fhuC) MVIS_2499(hatC)
MYA : MORIYA_2096(fhuC) MORIYA_2340(fhuC)
HAAH : HALA3H3_90003(fhuC)
HSX : HNO51_05140 HNO51_07725
AEL : NCTC12917_04249(fhuC)
CDIZ : CEDIAZO_00493(fhuC)
BUU : WS70_08145 WS70_10540 WS70_17455
BHG : I6G56_10335 I6G56_25870
BUD : AQ610_10030 AQ610_28455
BCM : Bcenmc03_1306 Bcenmc03_1610
BCEP : APZ15_12745 APZ15_30015
BPYR : ABD05_14010 ABD05_31015
BSEM : WJ12_08105 WJ12_24820
BANN : JFN94_08300 JFN94_22775
BGD : bgla_2g16910 bgla_4p1930
BUE : BRPE67_DCDS04230(feCT)
BXB : DR64_5853 DR64_7233(fhuC)
PTRO : G5S35_25450 G5S35_30315 G5S35_35610
PDIO : PDMSB3_2539(fhuC) PDMSB3_2887.1(fepC)
PSPU : NA29_12815 NA29_20350
POX : MB84_12415 MB84_26960
PNR : AT302_20550 AT302_25860
PCOM : NTU39_09145 NTU39_16960
BPT : Bpetpseudo_17(fhuC`)
MESP : C1M53_08025 C1M53_23470
ATA : AWN88_05710 AWN88_07230
AGT : EYD00_17950 EYD00_19420
ARUI : G6M88_05390 G6M88_14910 G6M88_23895
RIR : BN877_II0864 BN877_II1152(fhuC)
RPUS : CFBP5875_18115 CFBP5875_19630
ALEG : CFBP4996_21245 CFBP4996_27435
REC : RHECIAT_PA0000228(fhuC)
REP : IE4803_PA00229(fhuC)
REI : IE4771_PC00231(fhuC)
RLB : RLEG3_02500 RLEG3_04630
RHL : LPU83_pLPU83d1367(fhuC)
ROY : G3A56_22315 G3A56_23280
RSUL : N2599_27045 N2599_28165
RLW : RlegWSM1455_30555 RlegWSM1455_33550
RHIB : I8E17_23735 I8E17_32320
NEN : NCHU2750_09430 NCHU2750_45300
OIN : IAR37_13760 IAR37_22335
OPS : A8A54_14130 A8A54_21935
OCH : CES85_2900 CES85_4202(fhuC)
BOSE : RMR04_12990 RMR04_19320
STAR : G3545_26470 G3545_26660
APOL : K9D25_04130 K9D25_16715 K9D25_23250
AQI : J5J86_05315 J5J86_05340 J5J86_21460
MLD : U0023_18690 U0023_29945
MEY : TM49_07100 TM49_07435
RSH : Rsph17029_0086 Rsph17029_4124
PAMI : JCM7686_1159 JCM7686_pAMI5p011
PKD : F8A10_15180 F8A10_19310
PPRU : FDP22_06540 FDP22_07920
RCP : RCAP_rcp00109(fhuC2)
ABS : AZOBR_p170129(fhuC) AZOBR_p220061(fecE)
ABQ : ABAZ39_27880 ABAZ39_29415
AZT : TSH58p_30200 TSH58p_30260
AZZ : DEW08_18355 DEW08_20230
AARE : D3093_30620 D3093_32015
THAC : CSC3H3_15070 CSC3H3_22165
THAI : IT893_05100 IT893_15015
THGO : M9H61_07615 M9H61_18600
NACI : NUH88_05170 NUH88_18015
TMO : TMO_a0122(fhuC) TMO_b0220(fhuC) TMO_b0332(fhuC) TMO_d0048(fhuC)
BAZ : BAMTA208_16845(fhuC)
BFD : NCTC4823_00153(fhuC_1)
BHK : B4U37_04925(fecE) B4U37_21180
NTX : NQZ71_01025 NQZ71_02790 NQZ71_16895
NIL : L8T27_001300 L8T27_005080 L8T27_018920
BMEG : BG04_3820 BG04_5948
CSOA : LIS82_23360 LIS82_25845
PARG : PspKH34_01890(hfuC)
LSP : Bsph_0990 Bsph_2323(hfuC)
LFU : HR49_14655 HR49_21080
LYS : LBYS11_02765 LBYS11_08445
LYB : C3943_03445 C3943_19630
LPAK : GDS87_02830 GDS87_09575
LYC : FH508_0002630 FH508_0010225
LCAP : ICJ70_15775 ICJ70_21545
LIU : OU989_02510 OU989_08425
LYQ : MY533_08570 MY533_20975
BLEN : NCTC4824_04133(fhuC_3)
PUK : PU629_00245 PU629_08825
SAX : USA300HOU_0668(fhuC)
SUX : SAEMRSA15_05730(fhuA)
SUF : SARLGA251_05800(fhuC)
SAUT : SAI1T1_2004990(fhuA)
SAUJ : SAI2T2_1005010(fhuA)
SAUK : SAI3T3_1005000(fhuA)
SAUQ : SAI4T8_1004990(fhuA)
SAUV : SAI7S6_1005000(fhuC)
SAUW : SAI5S5_1004960(fhuC)
SAUX : SAI6T6_1004970(fhuC)
SAUY : SAI8T7_1005000(fhuC)
SDP : NCTC12225_02318(fhuC)
SCAP : AYP1020_0014(yusV_1)
SPIC : SAMEA4384060_2223(fhuC)
SSH : NCTC13712_00609(yusV_1)
SSIM : SAMEA4384339_0589(fhuA)
SSTE : SAMEA4384403_0327(fhuC)
LMOC : LMOSLCC5850_2021(fhuC)
LMW : LMOSLCC2755_2020(fhuC)
LMX : LMOSLCC2372_2026(fhuC)
LMZ : LMOSLCC2482_2023(fhuC)
LMON : LMOSLCC2376_1922(fhuC)
LMOS : LMOSLCC7179_1932(fhuC)
LMOO : LMOSLCC2378_1983(fhuC)
LMOY : LMOSLCC2479_2023(fhuC)
LMOT : LMOSLCC2540_2041(fhuC)
LMOA : LMOATCC19117_1978(fhuC)
LGZ : NCTC10812_00859(yusV_3)
BTHS : CNY62_04525(fecE) CNY62_07905
BLR : BRLA_c039640(yusV_2)
BRUM : NDK47_02325 NDK47_14275
BREH : HP435_06590 HP435_27575
POD : PODO_15915(fecE) PODO_16305(fecE)
PBJ : VN24_06980(fecE) VN24_22190(fecE) VN24_22410(fecE)
PDH : B9T62_13810(fecE) B9T62_22670(fecE)
PCHI : PC41400_15785(fecE) PC41400_19470
PTRI : KDC22_18030 KDC22_28320
PCEL : HUB94_04425 HUB94_26135
PTHI : NDS46_13640 NDS46_29155
PMAH : PTQ21_02850 PTQ21_22120
PDY : QJQ58_06035 QJQ58_08380 QJQ58_23210
PMAE : LMZ02_02640 LMZ02_10345
PNK : AASFL403_21385(mntB)
PKP : SK3146_03990(yusV_4) SK3146_05279(fhuC)
COHN : KCTCHS21_04510(fhuC)
PLIG : NAG76_05320 NAG76_10335 NAG76_17100
ACYC : JI721_02295 JI721_09390 JI721_12840
SOB : CSE16_07450 CSE16_17355
KUR : ASO14_2048 ASO14_631
KZO : NCTC404_01540(yusV_2) NCTC404_01627(yusV_3)
SPSY : AZE41_14565 AZE41_18850
VIJ : JNUCC6_15020 JNUCC6_17205
SPYM : M1GAS476_0391(fhuA)
SPH : MGAS10270_Spy0319(fhuA)
SPI : MGAS10750_Spy0318(fhuA)
SPJ : MGAS2096_Spy0341(fhuA)
SPK : MGAS9429_Spy0323(fhuA)
STG : MGAS15252_0350(fhuC)
SGG : SGGBAA2069_c17300(fhuC)
SMEN : SAMEA4412692_1104(yusV_2)
SFER : NCTC12278_01482(yusV_2)
SCAI : NCTC12191_00120(fhuA)
SPSU : NCTC13786_01731(fhuC)
SPOC : NCTC10925_01424(fhuC)
SURN : NCTC13766_01699(yusV_1)
EFAU : EFAU085_01781(fhuC)
EFU : HMPREF0351_11713(feuC)
CBO : CBO0313(fhuC1) CBO0689(fhuC2)
CBA : CLB_0356 CLB_0728(fhuC)
CBH : CLC_0371 CLC_0743(fhuC)
CBY : CLM_0381 CLM_0806(fhuC)
CBL : CLK_0090(fhuC) CLK_3503
CBB : CLD_0077(fhuC) CLD_0440
CBI : CLJ_B0366 CLJ_B0761(fhuC)
CBF : CLI_0383 CLI_0758(fhuC)
CBM : CBF_0351 CBF_0725(fhuC)
CBJ : H04402_00322 H04402_00763
CLD : CLSPO_c03440 CLSPO_c07120
CARG : RSJ17_09985 RSJ17_17355(fecE) RSJ17_17405(fecE) RSJ17_19595(fecE)
CGAS : J1C67_05870 J1C67_19200
CTAG : LL095_01300 LL095_02155
BPRO : PMF13cell1_02687(yusV)
ACEL : acsn021_16540(fhuC1)
PDF : CD630DERM_28750(fhuC)
TPET : TPHSE_11760(yusV_2)
CAD : Curi_c04000(fhuC2) Curi_c04930(fhuC3)
TIS : P3962_01560 P3962_06865
STIM : H1B31_03650 H1B31_10215
STED : SPTER_04430(yusV_2) SPTER_44300(yusV_4) SPTER_48940(yusV_5)
SSPH : SPSPH_038830(yusV_1) SPSPH_042430(yusV_2)
AARG : Aargi30884_22390(fhuC)
ABSI : A9CBEGH2_20220(fhuC)
AHAT : ADCFC_12320(fhuC) ADCFC_16400
SCYE : R2B67_01725 R2B67_15320
STRP : F750_5424(fhuC) F750_6698(fhuC)
SAMB : SAM23877_0803(fepC)
SCZ : ABE83_01760(fecE) ABE83_15560
SRN : A4G23_04766(yusV_4) A4G23_05179(yusV_5)
SPAV : Spa2297_01710(fecE)
SKY : D0C37_01300 D0C37_01895
SGM : GCM10017557_54870 GCM10017557_72330
SFIC : EIZ62_06185 EIZ62_29890
SFB : CP974_25515 CP974_27620
STRY : EQG64_19725 EQG64_32810
SVIO : HWN34_01130 HWN34_01700
KAB : B7C62_19945 B7C62_33975(fecE)
ACTU : Actkin_04258(yusV_5)
ATL : Athai_17410 Athai_59810
OHM : MSHRCOH1_08360(yusV)
» show all
Taxonomy
Reference
Authors
Koster W
Title
Iron(III) hydroxamate transport across the cytoplasmic membrane of Escherichia coli.
Journal
Reference
Authors
Speziali CD, Dale SE, Henderson JA, Vines ED, Heinrichs DE
Title
Requirement of Staphylococcus aureus ATP-binding cassette-ATPase FhuC for iron-restricted growth and evidence that it functions with more than one iron transporter.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.16
ExPASy - ENZYME nomenclature database: 7.2.2.16