KEGG   ENZYME: 7.2.2.18
Entry
EC 7.2.2.18                 Enzyme                                 
Name
ABC-type ferric citrate transporter;
ferric citrate transporting ATPase;
ferric citrate ABC transporter;
fecBCDE (gene names)
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
Sysname
ATP phosphohydrolase (ABC-type, iron(III) dicitrate-importing)
Reaction(IUBMB)
ATP + H2O + Fe3+-dicitrate-[dicitrate-binding protein][side 1] = ADP + phosphate + Fe3+-dicitrate[side 2] + [dicitrate-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Fe3+-dicitrate-[dicitrate-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Fe3+-dicitrate[side 2];
[dicitrate-binding protein][side 1]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from Escherichia coli interacts with a periplasmic substrate binding protein and mediates the high affinity uptake of Fe3+-citrate in the form of a mononuclear (containing one iron(III) ion and two citrate molecules) or dinuclear (containing 2 iron(III) ions) complexes.
History
EC 7.2.2.18 created 2000 as EC 3.6.3.34, part transferred 2018 to EC 7.2.2.18
Orthology
K23184  ferric citrate transport system ATP-binding protein
Genes
ECO: b4287(fecE)
ECJ: JW4247(fecE)
ECD: ECDH10B_4485(fecE)
EBW: BWG_3984(fecE)
ECOC: C3026_23120
EOJ: ECO26_5455
ECOO: ECRM13514_3864(fecE)
ECOH: ECRM13516_3709(fecE) ECRM13516_5063(fecE_2)
ESL: O3K_22040(fecE)
ESO: O3O_03340(fecE)
ESM: O3M_21940(fecE)
ECK: EC55989_4959(fecE)
ELH: ETEC_3166
ECW: EcE24377A_4864(fecE)
EUN: UMNK88_5225
ENA: ECNA114_2549(fecE)
ECOS: EC958_4784
ECOA: APECO78_02395
ECQ: ECED1_5151(fecE)
EUM: ECUMN_4855(fecE)
ECT: ECIAI39_4765(fecE)
EOC: CE10_5025(fecE)
EBR: ECB_04153(fecE)
ECOB: C3029_03140
EBL: ECD_04153(fecE)
EBE: B21_04116(fecE)
EBD: ECBD_3751
ECZ: ECS88_4860(fecE)
ELO: EC042_4776(fecE)
ECL: EcolC_0739
EAB: ECABU_c48990(fecE)
EDH: EcDH1_3713
EDJ: ECDH1ME8569_4142(fecE)
ECOJ: P423_23890 P423_24145
SSN: SSON_4459(fecE)
SDY: SDY_4293(fecE)
SDZ: Asd1617_05627
SHQ: A0259_03090
ECLE: ECNIH2_19590 ECNIH2_24370
ECLI: ECNIH5_22120
ECLZ: LI64_18020
ECLO: ENC_36580
EHM: AB284_06525
ECLC: ECR091_23340
EPT: HWQ17_11475(fecE)
EAS: Entas_1946
CSJ: CSK29544_00427
CSI: P262_05123
KPH: KPNIH24_27290
KPZ: KPNIH27_28715
KPG: KPNIH32_29305
KPC: KPNIH10_26550
KPJ: N559_5136
KPX: PMK1_a00048(yusV)
KPNE: KU54_00955
KPNU: LI86_27765
KOX: KOX_17840(fecE)
KOE: A225_2424
KOY: J415_19955(fecE)
KOM: HR38_16125
KOK: KONIH1_11630
KOC: AB185_24560
KQU: AVR78_26145
KQV: B8P98_28355
KLL: BJF97_12230 BJF97_31425
KLW: DA718_16890
KGR: JJJ10_16890(fecE)
KLM: BWI76_11365
RON: TE10_11720
RTG: NCTC13098_04354(yusV_2)
CKO: CKO_03838
CBRA: A6J81_03320
CYO: CD187_14360
CPOT: FOB25_02310(fecE)
CIF: AL515_11380
CPAR: CUC49_07060
KIE: NCTC12125_04071(yusV_3)
KAS: KATP_21670(fecE_1) KATP_45890(fecE_2)
LEF: LJPFL01_1530
YMA: DA391_05315
YEG: PL78_09605
RAQ: Rahaq2_4814
ECA: ECA1073(fecE)
PATR: EV46_05425
PATO: GZ59_11010(fecE)
PCT: PC1_0971
PCC: PCC21_010030
PPOA: BJK05_00085
PBRA: B5S52_16670
PPUJ: E2566_05555(fecE)
PARI: I2D83_17100(fecE)
PAQU: DMB82_0015440(fecE)
PVZ: OA04_11170(fecE)
PQU: IG609_015170(fecE)
PPOO: LW347_05500(fecE)
PCAC: OI450_18030(fecE)
PACB: M9782_07450(fecE)
PCOA: PJ912_19435(fecE)
PARL: PEC302110_09540(fecE)
PPEU: DUT67_16910(fecE)
ETA: ETA_30390(fecE)
EPE: CI789_22225
PAO: Pat9b_4943
PPHO: CTZ24_23640
PLU: plu4450(fecE)
PLUM: A4R40_22040
PAY: PAU_03945(fecE)
PAKH: B0X70_22495
PLUI: CE143_22540
XNE: XNC1_3745(fecE)
XNM: XNC2_3600(fecE)
HPR: PARA_03710(fecE)
HAY: C3V42_06495
HPIT: NCTC13334_00253(fecE_1)
HSEM: L3077_04335(fecE)
PMU: PM0128(fecE)
PMV: PMCN06_1175(fepC)
PUL: NT08PM_1208
PMP: Pmu_11850(fecE)
PMUL: DR93_1938
AAP: NT05HA_1297
AAZ: ADJ80_10385
AAT: D11S_0815
AAO: ANH9381_1140
AAN: D7S_01506
AAH: CF65_00799
AACN: AANUM_0975
AACT: ACT75_07960
ASEG: NCTC10977_01006(yusV)
AGJ: J5A60_02590(fecE)
GSS: NYR30_11010(fecE)
RPNE: NCTC8284_00333(fecE_1)
RHAE: IHV77_01310(fecE)
VPA: VPA1652
VPB: VPBB_A1516
VPK: M636_07070
VPF: M634_17730
VPH: VPUCM_21474
VHA: VIBHAR_06010
VCA: M892_21810
VAG: N646_3387
VEX: VEA_001072
VDB: AL552_03610
VHR: AL538_23515
VNA: PN96_03110
VRO: BSZ04_03630
VSP: VS_II1123
VEJ: VEJY3_11075(fecE)
VFU: vfu_B00837
VNI: VIBNI_B2158(fecE)
VFL: AL536_06970
VGA: BSQ33_20045
VSH: BSZ05_24920
VTA: B1255(fecE)
VNL: D3H41_22940
VCC: FAZ90_20165(fecE)
VAQ: FIV01_05215(yusV)
VSR: Vspart_03551(yusV_3)
VZI: G5S32_16480(fecE)
VGI: MID13_17700(fecE)
VJP: NP165_16900(fecE)
VPG: LZI70_19545(fecE)
VOS: KNV97_05010(fecE)
VCRA: IS519_19555(fecE)
VLE: ISX51_17340(fecE)
VSY: K08M4_40300(yusV_2)
VRU: RND59_17935(fecE)
VIB: VspSTUT11_08160(fecE)
VIS: VspSTUT16_38690(fecE)
AWD: AWOD_I_1553(pvuE)
PST: PSPTO_0760
PSB: Psyr_0664
PSYR: N018_03725
PSP: PSPPH_4633
PSAV: PSA3335_04085
PAMG: BKM19_004980
PCI: PCH70_06470
PAVL: BKM03_04350
PVD: CFBP1590_0922(fecE)
PCAB: JGS08_22610(fecE)
PCOF: POR16_21360(fecE)
PTRE: I9H09_04030(fecE)
PSYI: MME58_02965(fecE)
PAST: N015_04085(fecE)
PLIJ: KQP88_03200(fecE) KQP88_12555
PFS: PFLU_4088
PTV: AA957_24465
PAZO: AYR47_27190
PTOL: I7845_18875(fecE)
PMAB: U0037_20430(fecE)
PFW: PF1751_v1c35270
PFF: PFLUOLIPICF718255
PFX: A7318_17685
PLUL: FOB45_08115(fecE)
PRH: LT40_13550
PANR: A7J50_3734
PADE: C3B55_00613(yusV)
PTRT: HU722_0019110(fecE)
PALV: KSS97_16565
PCAS: LOY40_15825
PPEG: KUA23_20020(fecE)
PPAE: LDL65_00905(fecE)
PSKU: KUIN1_06780(fecE)
PCR: Pcryo_1285
PSO: PSYCG_06770
MYA: MORIYA_1816(fecE)
MOQ: HWV03_18420
HAF: C8233_02275
MMW: Mmwyl1_0690
MME: Marme_1435
MPC: Mar181_3003
MPRI: MP3633_3351
MARD: IBG28_18815(fecE)
MFOI: JSY38_07245(fecE)
MPRF: J8N69_10205(fecE)
MRHI: KDW99_02960(fecE)
MPON: MACH16_28320(fecE)
GSN: YC6258_05519
AVO: AMS64_13915
ASR: WL1483_1278(fecE)
CHJ: NCTC10426_00175(yusV)
CDIZ: CEDIAZO_01746(fecE)
CKS: H9L41_08790
MAER: DAI18_14100 DAI18_18600
LMIR: NCTC12852_01307(yusV_2)
POL: Bpro_4777
SMIO: CATMQ487_18780
EMX: FKV68_21315
ACUC: KZ699_19900
OPS: A8A54_12670(fecE)
PSF: PSE_2358(fhuC)
KVL: KVU_PB0046(fecE)
KVU: EIO_3231
KRO: BVG79_01540(fhuC)
LMD: METH_23575
MALG: MALG_00023
MALU: KU6B_57720
HAT: RC74_14750
SLAA: EUU25_01110
BSU: BSU07490(yfmF)
BSR: I33_0840
BSL: A7A1_1792
BSH: BSU6051_07490(yfmF)
BSY: I653_03760
BSUT: BSUB_00823(yfmF)
BSUL: BSUA_00823(yfmF)
BSUS: Q433_04235(fecE)
BSN: BSn5_15650
BSQ: B657_07490(yfmF)
BSX: C663_0773(yfmF)
BSP: U712_03805
BSS: BSUW23_03805(yfmF)
BST: GYO_1014
BIT: BIS30_14355(fecE)
BAE: BATR1942_01330
BSON: S101395_04646
BHT: DIC78_06045(fecE)
BMOJ: HC660_07940(fecF)
BTEQ: G4P54_03935(yfmF)
BIQ: AN935_03915(fecE)
BSTR: QI003_04115(yfmF)
BGY: BGLY_0397(yfmF)
BCAB: EFK13_04290(yfmF)
BRY: M0696_04265(yfmF)
BJS: MY9_0840
BACY: QF06_02645(fecE)
BACL: BS34A_08470(yfmF)
BALM: BsLM_0786
BZH: NF868_13760
BMH: BMWSH_3734(yfmF)
BGI: BGM20_18930(fecE)
PBUT: DTO10_07255
PFRI: L8956_21120
PERI: RE409_23180
MSEM: GMB29_11875
HYI: K2M58_05230
PALR: HGI30_07870
PDY: QJQ58_28170
PMAE: LMZ02_13515
PKP: SK3146_00699(yusV_1)
PGLU: A3958_03590
PACL: DCC85_06210
AACO: K1I37_13585
ALIC: GI364_05540
HHW: NCTC503_01767(yusV_3)
CLF: GJQ69_02955
SVJ: NQ490_00660
LASA: L9O85_08745
AMUR: ADH66_13665
BPEN: NQ488_04580
RRK: H8S51_017550
KIB: RBB56_03135
IBR: NQ514_03835
MMAX: LCQ47_01375
SGBI: P3F81_08700
AMUO: KWG62_01145
FBS: N510_001525(fecE)
UDE: JM47_00125
CKU: UL82_07350(yfmF)
CAUI: CAURIS_09195(yusV3)
CAPP: CAPP_03280(fhuC2)
CPYR: CYJ47_07605
MCHN: HCR76_10820
PROP: QQ658_01885
KSL: OG809_04430
TBER: QPC17_00820
DRA: DR_B0121
DGE: Dgeo_2759
DDR: Deide_2p00400
DMR: Deima_0289
DPT: Deipr_2585
DGO: DGo_PA0074(fepC)
DPD: Deipe_3853
DEZ: DKM44_07225(fecE)
DFC: DFI_17195(fecE)
DGA: DEGR_34010
DPH: EHF33_18230
DRD: LMT64_12995
DAQU: M8445_16265
DTAE: LAJ19_17855
DSC: ABOD76_01820
MRB: Mrub_2417
MRE: K649_10450
MTAI: Mtai_v1c20320
PPIO: CE91St28_11990
PYY: RAH42_10475
NALL: PP769_12110
NNEO: PQG83_02960
PARE: PYJP_06930
 » show all
Reference
1  [PMID:2651410]
  Authors
Staudenmaier H, Van Hove B, Yaraghi Z, Braun V
  Title
Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli.
  Journal
J Bacteriol 171:2626-33 (1989)
DOI:10.1128/jb.171.5.2626-2633.1989
  Sequence
[eco:b4290 b4289 b4288 b4287]
Reference
2  [PMID:26600288]
  Authors
Banerjee S, Paul S, Nguyen LT, Chu BC, Vogel HJ
  Title
FecB, a periplasmic ferric-citrate transporter from E. coli, can bind different forms of ferric-citrate as well as a wide variety of metal-free and metal-loaded  tricarboxylic acids.
  Journal
Metallomics 8:125-33 (2016)
DOI:10.1039/c5mt00218d
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.18
IUBMB Enzyme Nomenclature: 7.2.2.18
ExPASy - ENZYME nomenclature database: 7.2.2.18
BRENDA, the Enzyme Database: 7.2.2.18

  All links  
Gene (1311)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (336)   
   KEGG MGENES (974)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (11)   
   RefSeq(nuc) (1)   
   GenBank (5)   
   EMBL (5)   
Protein domain (5)   
   InterPro (5)   
All databases (1333)   

Download RDF
DBGET integrated database retrieval system