KEGG   ENZYME: 7.2.2.18Help
Entry
EC 7.2.2.18                 Enzyme                                 

Name
ABC-type ferric citrate transporter;
ferric citrate transporting ATPase;
ferric citrate ABC transporter;
fecBCDE (gene names)
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, iron(III) dicitrate-importing)
Reaction(IUBMB)
ATP + H2O + Fe3+-dicitrate-[dicitrate-binding protein][side 1] = ADP + phosphate + Fe3+-dicitrate[side 2] + [dicitrate-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Fe3+-dicitrate-[dicitrate-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Fe3+-dicitrate[side 2];
[dicitrate-binding protein][side 1]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from Escherichia coli interacts with a periplasmic substrate binding protein and mediates the high affinity uptake of Fe3+-citrate in the form of a mononuclear (containing one iron(III) ion and two citrate molecules) or dinuclear (containing 2 iron(III) ions) complexes.
History
EC 7.2.2.18 created 2000 as EC 3.6.3.34, part transferred 2018 to EC 7.2.2.18
Orthology
K23184  ferric citrate transport system ATP-binding protein
Genes
ECO: b4287(fecE)
ECJ: JW4247(fecE)
ECD: ECDH10B_4485(fecE)
EBW: BWG_3984(fecE)
EOJ: ECO26_5455
ECOO: ECRM13514_3864(fecE)
ECOH: ECRM13516_3709(fecE) ECRM13516_5063(fecE_2)
ESO: O3O_03340(fecE)
ESM: O3M_21940(fecE)
ESL: O3K_22040(fecE)
ECW: EcE24377A_4864(fecE)
ELH: ETEC_3166
ECQ: ECED1_5151(fecE)
ECK: EC55989_4959(fecE)
ECT: ECIAI39_4765(fecE)
EOC: CE10_5025(fecE)
EUM: ECUMN_4855(fecE)
ECZ: ECS88_4860(fecE)
ELO: EC042_4776(fecE)
EBR: ECB_04153(fecE)
EBD: ECBD_3751
EAB: ECABU_c48990(fecE)
EDJ: ECDH1ME8569_4142(fecE)
ENA: ECNA114_2549(fecE)
EBL: ECD_04153(fecE)
EBE: B21_04116(fecE)
ECOS: EC958_4784
SSN: SSON_4459(fecE)
SDY: SDY_4293(fecE)
ECLO: ENC_36580
ECLZ: LI64_18020
KPJ: N559_5136
KPX: PMK1_a00048(yusV)
KPNE: KU54_00955
KPNU: LI86_27765
KOX: KOX_17840(fecE)
KOE: A225_2424
KOY: J415_19955(fecE)
CKO: CKO_03838
RTG: NCTC13098_04354(yusV_2)
KIE: NCTC12125_04071(yusV_3)
ECA: ECA1073(fecE)
PATR: EV46_05425
PATO: GZ59_11010(fecE)
PCT: PC1_0971
ETA: ETA_30390(fecE)
PLU: plu4450(fecE)
PAY: PAU_03945(fecE)
XNE: XNC1_3745(fecE)
XNM: XNC2_3600(fecE)
HPR: PARA_03710(fecE)
HPIT: NCTC13334_00253(fecE_1)
PMU: PM0128(fecE)
PMV: PMCN06_1175(fepC)
PMP: Pmu_11850(fecE)
PMUL: DR93_1938
AAT: D11S_0815
AAN: D7S_01506
AACN: AANUM_0975
ASEG: NCTC10977_01006(yusV)
RPNE: NCTC8284_00333(fecE_1)
VPA: VPA1652(fecE)
VAG: N646_3387
VSP: VS_II1123
VEJ: VEJY3_11075(fecE)
VNI: VIBNI_B2158(fecE)
VTA: B1255(fecE)
AWD: AWOD_I_1553(pvuE)
PSB: Psyr_0664(fecE)
PSYR: N018_03725
PFS: PFLU_4088
PANR: A7J50_3734
PADE: C3B55_00613(yusV)
MYA: MORIYA_1816(fecE)
ASR: WL1483_1278(fecE)
CHJ: NCTC10426_00175(yusV)
LMIR: NCTC12852_01307(yusV_2)
OPS: A8A54_12670(fecE)
KVU: EIO_3231
KVL: KVU_PB0046(fecE)
KRO: BVG79_01540(fhuC)
PSF: PSE_2358(fhuC)
MALG: MALG_00023
BSU: BSU07490(yfmF)
BSR: I33_0840
BSL: A7A1_1792
BSH: BSU6051_07490(yfmF)
BSUT: BSUB_00823(yfmF)
BSUL: BSUA_00823(yfmF)
BSUS: Q433_04235(fecE)
BSS: BSUW23_03805(yfmF)
BST: GYO_1014
BSQ: B657_07490(yfmF)
BSX: C663_0773(yfmF)
BMH: BMWSH_3734(yfmF)
BJS: MY9_0840
BACY: QF06_02645(fecE)
BACL: BS34A_08470(yfmF)
BALM: BsLM_0786
BGY: BGLY_0397(yfmF)
BGI: BGM20_18930(fecE)
BIT: BIS30_14355(fecE)
HHW: NCTC503_01767(yusV_3)
CKU: UL82_07350(yfmF)
 » show all
Taxonomy
Reference
1  [PMID:2651410]
  Authors
Staudenmaier H, Van Hove B, Yaraghi Z, Braun V
  Title
Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli.
  Journal
J Bacteriol 171:2626-33 (1989)
DOI:10.1128/JB.171.5.2626-2633.1989
  Sequence
Reference
2  [PMID:26600288]
  Authors
Banerjee S, Paul S, Nguyen LT, Chu BC, Vogel HJ
  Title
FecB, a periplasmic ferric-citrate transporter from E. coli, can bind different forms of ferric-citrate as well as a wide variety of metal-free and metal-loaded  tricarboxylic acids.
  Journal
Metallomics 8:125-33 (2016)
DOI:10.1039/c5mt00218d
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.18
IUBMB Enzyme Nomenclature: 7.2.2.18
ExPASy - ENZYME nomenclature database: 7.2.2.18
BRENDA, the Enzyme Database: 7.2.2.18

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