KEGG   ENZYME: 7.2.2.2Help
Entry
EC 7.2.2.2                  Enzyme                                 

Name
ABC-type Cd2+ transporter;
cadmium-transporting ATPase (ambiguous);
ABC-type cadmium-transporter
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, heavy-metal-exporting)
Reaction(IUBMB)
ATP + H2O + Cd2+[side 1] = ADP + phosphate + Cd2+[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Cd2+[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Cd2+[side 2]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports some heavy metals, especially Cd2+, from the cytosol into the vacuole.
History
EC 7.2.2.2 created 2000 as EC 3.6.3.46, transferred 2018 to EC 7.2.2.2
Reference
1  [PMID:8626454]
  Authors
Li ZS, Szczypka M, Lu YP, Thiele DJ, Rea PA.
  Title
The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump.
  Journal
J Biol Chem 271:6509-17 (1996)
DOI:10.1074/jbc.271.11.6509
  Sequence
[sce:YDR135C]
Reference
2  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv Microb Physiol 40:81-136 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.2
IUBMB Enzyme Nomenclature: 7.2.2.2
ExPASy - ENZYME nomenclature database: 7.2.2.2
BRENDA, the Enzyme Database: 7.2.2.2

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