KEGG   ENZYME: 7.2.2.20Help
Entry
EC 7.2.2.20                 Enzyme                                 

Name
ABC-type Zn2+ transporter;
Zn2+-transporting ATPase;
Zn2+ ABC transporter;
znuABC (gene names)
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, Zn2+-importing)
Reaction(IUBMB)
ATP + H2O + Zn2+-[zinc-binding protein][side 1] = ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Zn2+-[zinc-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Zn2+[side 2];
[zinc-binding protein][side 1]
Comment
ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high-affinity import of Zn2+.
History
EC 7.2.2.20 created 2019
Reference
1  [PMID:9680209]
  Authors
Patzer SI, Hantke K
  Title
The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia  coli.
  Journal
Mol Microbiol 28:1199-210 (1998)
DOI:10.1046/j.1365-2958.1998.00883.x
  Sequence
Reference
2  [PMID:15802252]
  Authors
Hantke K
  Title
Bacterial zinc uptake and regulators.
  Journal
Curr Opin Microbiol 8:196-202 (2005)
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.20
IUBMB Enzyme Nomenclature: 7.2.2.20
ExPASy - ENZYME nomenclature database: 7.2.2.20
BRENDA, the Enzyme Database: 7.2.2.20

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