KEGG   ENZYME: 7.2.2.3
Entry
EC 7.2.2.3                  Enzyme                                 
Name
P-type Na+ transporter;
Na+-exporting ATPase (ambiguous);
ENA1 (gene name);
ENA2 (gene name);
ENA5 (gene name);
sodium transport ATPase (ambiguous);
sodium-translocating P-type ATPase
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
Sysname
ATP phosphohydrolase (P-type, Na+-exporting)
Reaction(IUBMB)
ATP + H2O + Na+[side 1] = ADP + phosphate + Na+[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Na+[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Na+[side 2]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme from yeast is involved in the efflux of Na+, with one ion being exported per ATP hydrolysed. Some forms can also export Li+ ions. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.4, ABC-type Na+ transporter.
History
EC 7.2.2.3 created 2000 as EC 3.6.3.7, modified 2001, transferred 20018 to EC 7.2.2.3
Orthology
K01536  P-type Na+/K+ transporter
Genes
AJM119047126
QSU111983520 112020431
PPP112273674 112276792 112295107
SCEYDR038C(ENA5) YDR039C(ENA2) YDR040C(ENA1)
SEUBDI49_0236
SPAOSPAR_D02580
AGOAGOS_AGL097C
ERCEcym_4150
KLAKLLA0_E14587g KLLA0_F20658g
KMXKLMA_40202(ENA5)
LTHKLTH0F08030g
VPOKpol_1052p20
ZROZYRO0E06930g
CGRCAGL0K12034g
NCSNCAS_0A10620(NCAS0A10620)
NDINDAI_0A05680(NDAI0A05680)
TPFTPHA_0A04000(TPHA0A04000) TPHA_0A04010(TPHA0A04010)
TBLTBLA_0E02620(TBLA0E02620)
TGBHG536_0C03450
TDLTDEL_0D03490(TDEL0D03490) TDEL_0G04940(TDEL0G04940)
KAFKAFR_0A01060(KAFR0A01060)
KNGKNAG_0H01200(KNAG0H01200)
ZMKHG535_0A03620
PPAPAS_chr1-1_0428
DHADEHA2C02552g DEHA2G09108g
PICPICST_73371(ENA5) PICST_74899(ENA2)
PGUPGUG_02728
SPAASPAPADRAFT_158103(ENA1) SPAPADRAFT_67476(ENA1.1)
LELLELG_01478
CALCAALFM_C100390WA(ENA2) CAALFM_C702910WA(ENA21)
CTPCTRG_04307 CTRG_04987 CTRG_04991
COTCORT_0B06970 CORT_0H02780
CDUCD36_00320 CD36_72570
CTENCANTEDRAFT_119074 CANTEDRAFT_135950
YLIYALI0A01023g YALI0E19338g
CLUCLUG_00309
CLUSA9F13_08g01177
CAURCJI97_000988 CJI97_001608
SLBAWJ20_3228(ENA5)
PKZC5L36_0A11250 C5L36_0A11260
BNNFOA43_004483
BBRXBRETT_002302
OPAHPODL_03387
NCRNCU05046(ena-1) NCU07966 NCU08147(ph7)
NTENEUTE1DRAFT144929(NEUTE1DRAFT_144929) NEUTE1DRAFT86499(NEUTE1DRAFT_86499) NEUTE1DRAFT88512(NEUTE1DRAFT_88512)
SMPSMAC_03602 SMAC_07599 SMAC_08578
PANPODANSg1069 PODANSg2243 PODANSg445 PODANSg4612
MTMMYCTH_112905 MYCTH_2144990 MYCTH_2305754
CTHRCTHT_0020740 CTHT_0020970 CTHT_0030720 CTHT_0049790
MGRMGG_02074 MGG_05078 MGG_10730 MGG_13279
PPEIPpBr36_00030 PpBr36_02715 PpBr36_03455 PpBr36_10562
TMNUCRPA7_3618 UCRPA7_4253 UCRPA7_5207
SSCKSPSK_02183
FGRFGSG_02677 FGSG_04245 FGSG_04919 FGSG_04995 FGSG_08985
FPUFPSE_00384 FPSE_03963 FPSE_07116 FPSE_08743 FPSE_12290
FVRFVEG_03567 FVEG_06648 FVEG_06769 FVEG_10435 FVEG_16502
FOXFOXG_05702 FOXG_06571 FOXG_06575 FOXG_06687 FOXG_06691 FOXG_07251 FOXG_07255 FOXG_09046 FOXG_10377 FOXG_11383 FOXG_20003
NHENECHADRAFT_100814 NECHADRAFT_35238 NECHADRAFT_43112 NECHADRAFT_62632 NECHADRAFT_65962 NECHADRAFT_70849
TRETRIREDRAFT_122972 TRIREDRAFT_81430 TRIREDRAFT_81536
TRRM419DRAFT_139005 M419DRAFT_142734 M419DRAFT_83372
MAWMAC_01178 MAC_06648 MAC_07338 MAC_07846
MAJMAA_04816 MAA_05556 MAA_08450 MAA_09724
CMTCCM_01629 CCM_02511 CCM_04844 CCM_08837
PLJVFPFJ_01534 VFPFJ_04629 VFPFJ_06044 VFPFJ_06500 VFPFJ_09351 VFPFJ_10780
VALVDBG_02460 VDBG_02955 VDBG_03550 VDBG_06477 VDBG_07580
VDAVDAG_02935 VDAG_03863 VDAG_05014 VDAG_09301 VDAG_09836
CFJCFIO01_05232 CFIO01_06516 CFIO01_08176 CFIO01_08329 CFIO01_10630
CLUPCLUP02_07144 CLUP02_07238 CLUP02_11487 CLUP02_13015 CLUP02_15390
CHIGCH63R_00134 CH63R_03608 CH63R_03689 CH63R_05000 CH63R_11099
SAPOSAPIO_CDS10188 SAPIO_CDS10460 SAPIO_CDS2534 SAPIO_CDS5079 SAPIO_CDS5332
ELAUCREL1_4203 UCREL1_663 UCREL1_8093
PFYPFICI_00118 PFICI_01488 PFICI_15126 PFICI_15176
SSLSS1G_06551 SS1G_10477
BFUBCIN_11g03050 BCIN_14g04570 BCIN_15g05670
MBEMBM_01457 MBM_03723
PSCOLY89DRAFT_643844
GLZGLAREA_04743 GLAREA_09795 GLAREA_11186
ANIAN1628.2 AN6642.2 AN7664.2
AFMAFUA_2G01320 AFUA_4G09440 AFUA_6G03690
ACTACLA_094630 ACLA_096890
NFINFIA_033620 NFIA_050200 NFIA_106580
AORAO090009000591 AO090023000590 AO090701000406
ANGANI_1_1216134(An15g01830) ANI_1_64084(An09g00690)
AFVAFLA_004921 AFLA_006936 AFLA_010781
ALUCAKAW2_40067A AKAW2_60514A
ACHEACHE_10071S ACHE_50116S
APUUAPUU_10609A APUU_20139A APUU_21503S APUU_60955A APUU_80232S
PCSPc16g14380 Pc20g05820 Pc20g13400 Pc21g21610
PDPPDIP_16990
TMFPMAA_040300
TRGTRUGW13939_02730 TRUGW13939_08840
CIMCIMG_00162 CIMG_03108 CIMG_12859(CIMG00571)
CPWCPC735_010390 CPC735_056720 CPC735_059820
UREUREG_00257 UREG_00592 UREG_02849
PBLPAAG_05329 PAAG_11749(PAAG_03790) PAAG_12330(PAAG_07077)
PBNPADG_01602 PADG_03294 PADG_06672
ABEARB_02138 ARB_02320 ARB_03734 ARB_05763
TVETRV_01501 TRV_04479 TRV_05052 TRV_06589
AJEHCAG_02264 HCAG_06089 HCAG_07215
BGHBDBG_00747 BDBG_07515 BDBG_16537
PNOSNOG_09636 SNOG_11155 SNOG_15715
PTEPTT_09305 PTT_12722 PTT_14661
BZECOCCADRAFT_3848 COCCADRAFT_538 COCCADRAFT_6187
BSCCOCSADRAFT_182008 COCSADRAFT_188039 COCSADRAFT_25174
BORCOCMIDRAFT_24070 COCMIDRAFT_4198 COCMIDRAFT_88295
AALTCC77DRAFT_1015658 CC77DRAFT_1018468 CC77DRAFT_742985
ZTRMYCGRDRAFT_100176 MYCGRDRAFT_74566 MYCGRDRAFT_84460
PFJMYCFIDRAFT_149581 MYCFIDRAFT_59513
FFUCLAFUR5_02271 CLAFUR5_07559
BCOMBAUCODRAFT_81255
NPAUCRNP2_1716 UCRNP2_2244 UCRNP2_6680
TMLGSTUM_00000681001 GSTUM_00005356001 GSTUM_00008991001
SPOSPBC839.06(cta3)
CNECNA05130
CNBCNBA4950
CNGCNAG_00531
CGICGB_A5410C
TASAA1Q1_03170 A1Q1_03630
ADLAURDEDRAFT_109639 AURDEDRAFT_147307 AURDEDRAFT_99896
CCICC1G_00228 CC1G_07450
PCUBJR316_0005025
MRRMoror_11414 Moror_2390
MOREE1B28_003858 E1B28_012936
SCMSCHCO_02616602(SCHCODRAFT_02616602)
WSEWALSEDRAFT_53229(cta3)
WICJ056_000751 J056_002156
UMAUMAG_00204 UMAG_15043
PFPPFL1_00514 PFL1_02641 PFL1_04558
MGLMGL_3722
MSYMMSY001_0060
ACANACA1_065450
TBRTb09.244.2570
TBGTbgDal_IX9590
TCR506241.70 510769.120
LMALMJF_35_2080
LIFLINJ_35_2080
LDOLDBPK_352080
LMILMXM_34_2080
LBZLBRM_34_1990
LPANLPMP_341910
NGRNAEGRDRAFT_202
 » show all
Reference
1  [PMID:7664728]
  Authors
Wieland J, Nitsche AM, Strayle J, Steiner H, Rudolph HK
  Title
The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane.
  Journal
EMBO J 14:3870-82 (1995)
DOI:10.1002/j.1460-2075.1995.tb00059.x
  Sequence
Reference
2  [PMID:9224683]
  Authors
Catty P, de Kerchove d'Exaerde A, Goffeau A.
  Title
The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases.
  Journal
FEBS Lett 409:325-32 (1997)
DOI:10.1016/S0014-5793(97)00446-8
  Sequence
Reference
3  [PMID:9315618]
  Authors
Benito B, Quintero FJ, Rodriguez-Navarro A
  Title
Overexpression of the sodium ATPase of Saccharomyces cerevisiae: conditions for phosphorylation from ATP and Pi.
  Journal
Biochim Biophys Acta 1328:214-26 (1997)
DOI:10.1016/s0005-2736(97)00098-9
  Sequence
[sce:YDR040C]
Reference
4  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv Microb Physiol 40:81-136 (1998)
DOI:10.1016/s0065-2911(08)60130-7
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.3
IUBMB Enzyme Nomenclature: 7.2.2.3
ExPASy - ENZYME nomenclature database: 7.2.2.3
BRENDA, the Enzyme Database: 7.2.2.3

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