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Entry
EC 7.2.2.3                  Enzyme                                 

Name
P-type Na+ transporter;
Na+-exporting ATPase (ambiguous);
ENA1 (gene name);
ENA2 (gene name);
ENA5 (gene name);
sodium transport ATPase (ambiguous);
sodium-translocating P-type ATPase
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (P-type, Na+-exporting)
Reaction(IUBMB)
ATP + H2O + Na+[side 1] = ADP + phosphate + Na+[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Na+[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Na+[side 2]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme from yeast is involved in the efflux of Na+, with one ion being exported per ATP hydrolysed. Some forms can also export Li+ ions. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.4, ABC-type Na+ transporter.
History
EC 7.2.2.3 created 2000, as EC 3.6.3.7, modified 2001, transferred 20018 to EC 7.2.2.3
Orthology
K01536  P-type Na+/K+ transporter
Genes
PPP: 112273674 112276792 112295107
SCE: YDR038C(ENA5) YDR039C(ENA2) YDR040C(ENA1)
AGO: AGOS_AGL097C
ERC: Ecym_4150
KLA: KLLA0_E14587g KLLA0_F20658g
KMX: KLMA_40202(ENA5)
LTH: KLTH0F08030g
VPO: Kpol_1052p20
ZRO: ZYRO0E06930g
CGR: CAGL0K12034g
NCS: NCAS_0A10620(NCAS0A10620)
NDI: NDAI_0A05680(NDAI0A05680)
TPF: TPHA_0A04000(TPHA0A04000) TPHA_0A04010(TPHA0A04010)
TBL: TBLA_0E02620(TBLA0E02620)
TDL: TDEL_0D03490(TDEL0D03490) TDEL_0G04940(TDEL0G04940)
KAF: KAFR_0A01060(KAFR0A01060)
PIC: PICST_73371(ENA5) PICST_74899(ENA2)
SPAA: SPAPADRAFT_158103(ENA1) SPAPADRAFT_67476(ENA1.1)
SLB: AWJ20_3228(ENA5)
NCR: NCU05046(ena-1) NCU07966 NCU08147(ph7)
NTE: NEUTE1DRAFT144929(NEUTE1DRAFT_144929) NEUTE1DRAFT86499(NEUTE1DRAFT_86499) NEUTE1DRAFT88512(NEUTE1DRAFT_88512)
SSCK: SPSK_02183
ANG: ANI_1_1216134(An15g01830) ANI_1_64084(An09g00690)
PBL: PAAG_05329 PAAG_11749(PAAG_03790) PAAG_12330(PAAG_07077)
SPO: SPBC839.06(cta3)
CNE: CNA05130
CNB: CNBA4950
WSE: WALSEDRAFT_53229(cta3)
MGL: MGL_3722
 » show all
Taxonomy
Reference
1  [PMID:7664728]
  Authors
Wieland J, Nitsche AM, Strayle J, Steiner H, Rudolph HK.
  Title
The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane.
  Journal
EMBO J 14:3870-82 (1995)
  Sequence
Reference
2  [PMID:9224683]
  Authors
Catty P, de Kerchove d'Exaerde A, Goffeau A.
  Title
The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases.
  Journal
FEBS Lett 409:325-32 (1997)
DOI:10.1016/S0014-5793(97)00446-8
  Sequence
Reference
3  [PMID:9315618]
  Authors
Benito B, Quintero FJ, Rodriguez-Navarro A
  Title
Overexpression of the sodium ATPase of Saccharomyces cerevisiae: conditions for phosphorylation from ATP and Pi.
  Journal
Biochim Biophys Acta 1328:214-26 (1997)
  Sequence
[sce:YDR040C]
Reference
4  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv Microb Physiol 40:81-136 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.3
IUBMB Enzyme Nomenclature: 7.2.2.3
ExPASy - ENZYME nomenclature database: 7.2.2.3
BRENDA, the Enzyme Database: 7.2.2.3

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