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Entry
EC 7.2.2.4                  Enzyme                                 

Name
ABC-type Na+ transporter;
natAB (gene names)
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, Na+-exporting)
Reaction(IUBMB)
ATP + H2O + Na+[side 1] = ADP + phosphate + Na+[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Na+[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Na+[side 2]
Comment
ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. This bacterial enzyme, characterized from Bacillus subtilis, exports Na+ ions out of the cell. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.3, P-type Na+ transporter.
History
EC 7.2.2.4 created 2018
Orthology
K09697  sodium transport system ATP-binding protein
Genes
XFA: XF_2329
XFT: PD_1361(natA)
XFM: Xfasm12_1501
XFN: XfasM23_1446
XFF: XFLM_00925
XFL: P303_06520
XFS: D934_10900
XFH: XFHB_03430
XTW: AB672_07600
XCC: XCC3969(natA)
XCB: XC_4059
XCP: XCR_0302
XCV: XCV4144(natA)
XAX: XACM_3921(natA)
XAC: XAC4054(natA)
XCI: XCAW_00248(natA)
XOO: XOO0388(natA)
XOM: XOO0351(XOO0351)
XOP: PXO_02799
XOR: XOC_4105
XAL: XALC_3005(natA)
XPH: XppCFBP6546_14210(XppCFBP6546P_14210)
SML: Smlt4511
SMT: Smal_3873
SMZ: SMD_4058
PSUW: WQ53_08115
PSD: DSC_00955
LEZ: GLE_5353(natA)
LEM: LEN_4879
DKO: I596_3780
SON: SO_0070(natA)
SDN: Sden_0067
SFR: Sfri_3978
SAZ: Sama_3576
SBL: Sbal_4279
SLO: Shew_3781
SSE: Ssed_4461
SPL: Spea_4191
SHL: Shal_0061
SWD: Swoo_4865
SWP: swp_0106
SVO: SVI_4294(natA)
SPSW: Sps_05613
ILO: IL0481(natA_2)
CPS: CPS_0723(natA)
PHA: PSHAa1626
PAT: Patl_2951
PSM: PSM_A1599
PSEO: OM33_10845
PTN: PTRA_a2021(natA)
PEA: PESP_a2039(natA)
PSPO: PSPO_a1583(natA)
PART: PARC_a1897(natA)
PTU: PTUN_a2026(natA)
PNG: PNIG_a2133(natA)
PTD: PTET_a1850(natA)
PSEN: PNC201_08245(ybhF3) PNC201_10085(yxlF3)
AMAL: I607_04370
AMAE: I876_04580
AMAO: I634_04755
AMAD: I636_04600
AMAI: I635_04575
AMAG: I533_04330
AMAC: MASE_04215
AAUS: EP12_04560
GNI: GNIT_2230(natA)
GPS: C427_1723
FBL: Fbal_1484
CJA: CJA_0603(natA)
SDE: Sde_3736
SAGA: M5M_06480
MICC: AUP74_01352(ybhF_1)
MMAI: sS8_0168
GAI: IMCC3135_23080(natA_3)
KKO: Kkor_1935
KGE: TQ33_0605
TBN: TBH_C2829
MPT: Mpe_A3800
JAG: GJA_4608
RGE: RGE_00500(natA)
MXA: MXAN_6827(natA)
CCX: COCOR_07408(natA)
SCL: sce0659(natA)
HOH: Hoch_3195
BSU: BSU02750(natA)
BSR: I33_0316
BSL: A7A1_1923
BSH: BSU6051_02750(natA)
BSUT: BSUB_00324(natA)
BSUL: BSUA_00324(natA)
BSUS: Q433_01675
BST: GYO_0476
BSQ: B657_02750(natA)
BSX: C663_0266(natA)
BPU: BPUM_0252
BPUM: BW16_01610
BPUS: UP12_01590
BMQ: BMQ_1211(natA)
BMD: BMD_1196(natA)
BMEG: BG04_3512
BJS: MY9_0280
BACW: QR42_01565
BACY: QF06_00330
BACL: BS34A_03300(natA_1)
BALM: BsLM_0286
LWE: lwe0700
BBE: BBR47_07040(natA)
BLR: BRLA_c005380(ybhF_2)
BTS: Btus_3144
CAC: CA_C3551(natA)
CAE: SMB_G3592(natA)
CAY: CEA_G3557
CTC: CTC_01486(natA)
CTET: BN906_01651(natA)
CBO: CBO2239
CBA: CLB_2178
CBH: CLC_2161
CBY: CLM_2445
CBL: CLK_1679
CBB: CLD_2337
CBI: CLJ_B2450
CBF: CLI_2288
CBM: CBF_2277
CKL: CKL_3011
CKR: CKR_2659
CPAS: Clopa_0174
CPAT: CLPA_c08480(natA1)
CPAE: CPAST_c08480(natA1)
CLT: CM240_2696(natA)
CBV: U729_1171
CSQ: CSCA_1972
CTYK: CTK_C12230(natA)
CTH: Cthe_2942
RIX: RO1_21350
RIM: ROI_08690
CPY: Cphy_0114
HSD: SD1D_0177
CBAR: PATL70BA_1648(natA)
TTE: TTE0410(CcmA2)
CSC: Csac_2502
ATE: Athe_0113
APAL: BN85409390
MBJ: KQ51_01784(ybhF)
ELE: Elen_1130
EYY: EGYY_10620(CcmA)
GPA: GPA_31410
GVI: gll0052
ATM: ANT_25720(natA)
PBF: CFX0092_A2520(natA)
DRA: DR_0927
DGE: Dgeo_1675
DFC: DFI_05605
TRA: Trad_2343
TTH: TT_C1559
TTJ: TTHA1924
TSC: TSC_c24770(natA)
TAQ: TO73_2364
MRB: Mrub_1791
OTE: Oter_1528
OBG: Verru16b_00937(ybhF_1)
RBA: RB6469 RB7633(natA)
PIR: VN12_01280(ybhF_1) VN12_03175(ybhF_3)
PLS: VT03_02120(ybhF_1) VT03_02900(ybhF_2)
PLH: VT85_13675(ybhF_1)
FMR: Fuma_02068(ybhF_5) Fuma_04071(ybhF_8)
TTF: THTE_0885
GES: VT84_38590(drrA_7)
SACI: Sinac_6078
PBOR: BSF38_00882(natA_2)
CBAL: M667_07640
CBAT: M666_07675
CACI: CLOAM0955(ccmA)
KOL: Kole_1193
MINF: MESINF_0583(natA)
 » show all
Taxonomy
Reference
1  [PMID:9106203]
  Authors
Cheng J, Guffanti AA, Krulwich TA.
  Title
A two-gene ABC-type transport system that extrudes Na+ in Bacillus subtilis is induced by ethanol or protonophore.
  Journal
Mol Microbiol 23:1107-20 (1997)
DOI:10.1046/j.1365-2958.1997.2951656.x
  Sequence
Reference
2  [PMID:17322186]
  Authors
Ogura M, Tsukahara K, Hayashi K, Tanaka T
  Title
The Bacillus subtilis NatK-NatR two-component system regulates expression of the  natAB operon encoding an ABC transporter for sodium ion extrusion.
  Journal
Microbiology 153:667-75 (2007)
DOI:10.1099/mic.0.2006/003673-0
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.4
IUBMB Enzyme Nomenclature: 7.2.2.4
ExPASy - ENZYME nomenclature database: 7.2.2.4
BRENDA, the Enzyme Database: 7.2.2.4

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