KEGG   ENZYME: 7.2.4.1Help
Entry
EC 7.2.4.1                  Enzyme                                 

Name
carboxybiotin decarboxylase;
MadB;
carboxybiotin protein decarboxylase
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to decarboxylation
BRITE hierarchy
Sysname
carboxybiotinyl-[protein] carboxy-lyase
Reaction(IUBMB)
a carboxybiotinyl-[protein] + n Na+[side 1] + H+[side 2] = CO2 + a biotinyl-[protein] + n Na+[side 2] (n = 1--2) [RN:R09509]
Reaction(KEGG)
Substrate
carboxybiotinyl-[protein] [CPD:C18047];
Na+[side 1];
H+[side 2]
Product
CO2 [CPD:C00011];
biotinyl-[protein] [CPD:C18046];
Na+[side 2] (n = 1--2)
Comment
The integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra is a component of the multienzyme complex EC 4.1.1.89, biotin-dependent malonate decarboxylase. The free energy of the decarboxylation reaction is used to pump Na+ out of the cell. The enzyme is a member of the Na+-translocating decarboxylase family, other members of which include EC 7.2.4.2 [oxaloacetate decarboxylase (Na+ extruding)] and EC 7.2.4.3 [(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)] [2].
History
EC 7.2.4.1 created 2008 as EC 4.3.99.2, transferred 2018 to EC 7.2.4.1
Orthology
K20509  carboxybiotin decarboxylase
Genes
EFE: EFER_0028(oadB) EFER_3127
STY: STY0063(oadB) STY3531(oadB)
STT: t0056(oadB) t3266(oadB)
SEX: STBHUCCB_34540 STBHUCCB_650
SENT: TY21A_00290 TY21A_16565
STM: STM0054 STM0768(dcoB) STM3351(oadB)
SEO: STM14_0064 STM14_0892(dcoB) STM14_4043(oadB)
SEV: STMMW_00551 STMMW_08201 STMMW_33501
SEY: SL1344_0055 SL1344_0745(dcoB) SL1344_3323(oadB2)
SEM: STMDT12_C00550 STMDT12_C08210 STMDT12_C34090
SEF: UMN798_0061(oadB2) UMN798_0833(oadB2) UMN798_3643(oadB2)
SEND: DT104_00551(oadB2) DT104_07841(dcoB) DT104_33441
SPT: SPA0055(oadB) SPA3218(oadB)
SEI: SPC_0058(oadB) SPC_0764(oadB) SPC_3421(oadB)
SEC: SCH_0048(oadB) SCH_0766(oadB) SCH_3289(oadB)
SEG: SG0057 SG0746(oadB2) SG3241(oadB3)
KPU: KP1_4950(oadB)
KPP: A79E_0477
KPT: VK055_2545(oadB) VK055_3841(oadB2)
KPE: KPK_0485(oadB_2) KPK_4719(oadB_1)
KPJ: N559_4403
KPX: PMK1_01144(oadB)
KPNU: LI86_22620
KPNK: BN49_0484(oadB_C) BN49_4310(oadB_N)
EAR: CCG31803
CAMA: F384_01170
HDU: HD_0782(oadB)
HPAZ: K756_01235
HSO: HS_0203(oadB)
HSM: HSM_0071
PMU: PM1423
PMV: PMCN06_1681(oadB)
PMP: Pmu_16740(oadB)
PMUL: DR93_277(oadB)
PDAG: 4362423_01743(oadB)
PAET: NCTC13378_01917(oadB)
MSU: MS0038(oadB)
MHT: D648_4970
MHAT: B824_21790
MHX: MHH_c10410(oadB)
MHAE: F382_10330
MHAM: J450_09255
MHAO: J451_10550
MHAL: N220_02425
MHAQ: WC39_11425
MHAY: VK67_11430
MVI: X808_3670
MVG: X874_3760
APL: APL_1377(oadB)
APJ: APJL_1395(oadB)
APA: APP7_1428(oadB)
ASU: Asuc_0301
AAT: D11S_1381
AAN: D7S_00029
AACN: AANUM_1711
ASEG: NCTC10977_01471(oadB)
BTO: WQG_15840
BTRE: F542_6220
BTRH: F543_7400
BTRA: F544_16220
RPNE: NCTC8284_00504(oadB)
VCO: VC0395_A0086(oadB-1) VC0395_A0319(oadB-2)
VCR: VC395_0568(oadB-1) VC395_0809(oadB-2)
VCM: VCM66_0509(oadB-1) VCM66_0750(oadB-2)
VVU: VV1_1602
VVY: VV2798
VPA: VP2543
VPB: VPBB_2365
VAG: N646_1636
VSP: VS_2568
VNI: VIBNI_A0154(oadB2)
VAU: VANGNB10_cI0455(oadB-1) VANGNB10_cI1186(oadB-2)
VSC: VSVS12_02745(oadB)
VTA: A0111(oadB) B0177(oadB)
VFI: VF_0540(oadB)
PPR: PBPRA2299(T3266) PBPRA3050(T3266)
PMY: Pmen_2892
PMK: MDS_1765
PSA: PST_1378
PSTT: CH92_07865
SFR: Sfri_1067
SAZ: Sama_1053
SBL: Sbal_1026
SLO: Shew_1221
SSE: Ssed_1322
SPL: Spea_1200
SHL: Shal_1237
SWP: swp_1380
SVO: SVI_3159(oadB)
SPSW: Sps_04082
ILO: IL1734(oadB)
CPS: CPS_1050(oadB)
PHA: PSHAa0540(oadB)
PAT: Patl_3011
PSM: PSM_A0587(oadB)
PSEO: OM33_13300
PTN: PTRA_a0612(oadB)
PEA: PESP_a0737(oadB)
PSPO: PSPO_a2228(oadB)
PART: PARC_a3300(oadB)
PTU: PTUN_a1102(oadB)
PNG: PNIG_a0652(oadB)
PTD: PTET_a0649(oadB)
PSEN: PNC201_12865(oadB)
PAGA: PAGA_a3166(oadB)
MAQ: Maqu_0972
MHC: MARHY2313
MAD: HP15_1332
MBS: MRBBS_1501(oadB)
AMAL: I607_05280
AMAE: I876_05575
AMAO: I634_05600
AMAD: I636_05510
AMAI: I635_05475
AMAG: I533_05190
AMAC: MASE_05085
AAUS: EP12_05510
GNI: GNIT_2323(oadB)
GPS: C427_3629
SALH: HMF8227_02229(oadB)
PIN: Ping_3375
FBL: Fbal_0863
CJA: CJA_2758
SDE: Sde_1307
SAGA: M5M_00815
MICC: AUP74_02105(oadB)
MCA: MCA2479(oadB)
METL: U737_10365
MAH: MEALZ_0543(oadB)
MMAI: sS8_1423
MEJ: Q7A_2132
MEC: Q7C_233
CYQ: Q91_0724
CZA: CYCME_1869(oadB)
HCH: HCH_05201
CSA: Csal_0694
HEL: HELO_3734(oadB)
HAM: HALO3828
HCO: LOKO_02895(oadB)
HBE: BEI_3145(oadB)
ABO: ABO_0845(oadB)
ADI: B5T_01561(oadB)
APAC: S7S_07075
AXE: P40_07280
KKO: Kkor_1246
TOL: TOL_2689
OAI: OLEAN_C28130(oadB)
TAU: Tola_0402
OCE: GU3_15045
RMA: Rmag_0847
VOK: COSY_0772(oadB)
EBH: BSEPE_1238(oadB)
ENM: EBS_1205(oadB)
RGE: RGE_11560
SUA: Saut_1374
SULR: B649_01475
CPIN: CPIN18020_1008(oadB)
AHS: AHALO_1371(oadB)
AMYT: AMYT_1453(oadB)
SDL: Sdel_0605
SMUL: SMUL_0790
SHAL: SHALO_0794
HYO: NNO_1527
NIS: NIS_1302
SUN: SUN_1432
NAM: NAMH_1020
GLO: Glov_1820
DHY: DESAM_20123(gcdB)
DPS: DP0687
DSF: UWK_01573
DOL: Dole_2282
DML: Dmul_03490(oadB1) Dmul_10450(oadB2) Dmul_25040(gcdB)
DAL: Dalk_1191
DAT: HRM2_06280(oadB1) HRM2_38530(oadB2) HRM2_38660(oadB3)
DTO: TOL2_C10000(oadB)
SFU: Sfum_3585
DBR: Deba_2621
RPB: RPB_3300
RPC: RPC_1055
BLAG: BLTE_21940
RCP: RCAP_rcp00132(oadB)
RSU: NHU_02470
RHC: RGUI_1051
MGRY: MSR1_01310(madB)
MAGQ: MGMAQ_2139
MGM: Mmc1_3197
SPYA: A20_0934(gcdB) A20_0940(gcdB)
SPS: SPs1031
STG: MGAS15252_0895(oadB.1) MGAS15252_0901(oadB.2)
STX: MGAS1882_0890(oadB.1) MGAS1882_0896(oadB.2)
SMU: SMU_1017(oadB)
SMC: SmuNN2025_1006(oadB)
SMJ: SMULJ23_1015(oadB)
SMUA: SMUFR_0887(oadB)
SEZ: Sez_0992(oadB)
SEQ: SZO_09780
SEZO: SeseC_01292(oadB)
SEQU: Q426_04240
SEU: SEQ_1203
SUB: SUB1591(gcdB)
SDS: SDEG_0989(oadB) SDEG_0996
SDC: SDSE_1018(oadB) SDSE_1025(gcdB)
STK: STP_0112(gcdB)
SIK: K710_0372
LSA: LCA_1229(oadB)
LCA: LSEI_1862
LPAP: LBPC_1820
LCB: LCABL_20860(oadB)
LCS: LCBD_2055
LCE: LC2W_2037
LCW: BN194_20360(gcdB)
LRH: LGG_01918(oadB)
LRG: LRHM_1841
LRL: LC705_01906(oadB)
LRA: LRHK_1906
EFA: EF3324
EFL: EF62_0383(oadD)
EFI: OG1RF_12569(gcdB)
EFD: EFD32_2875(oadD)
EFS: EFS1_2724(oadB)
EFN: DENG_03217(oadB)
EFQ: DR75_2041
ECAS: ECBG_03043
EMU: EMQU_1788(gcdB)
THL: TEH_07880
CRN: CAR_c13490(oadB)
CARC: NY10_724
JDA: BW727_101587(gcdB)
CACE: CACET_c36760(gcdB)
AOE: Clos_0443
ASF: SFBM_1184
ASM: MOUSESFB_1096(oadB)
ASB: RATSFB_1016(oadB)
CTH: Cthe_0509
HSC: HVS_11090(gcdB2)
CSS: Cst_c06330(gcdB) Cst_c12080(oadB)
CSD: Clst_0601(oadB1) Clst_1166(oadB2)
ESR: ES1_14170
ESU: EUS_07390
RUM: CK1_07290
RUS: RBI_I01165(gcdB)
BPB: bpr_I1229
BFI: CIY_18060
BHU: bhn_I1151
RIX: RO1_15620
RIM: ROI_21890
COO: CCU_25780
CCT: CC1_18390
ROB: CK5_25600
RTO: RTO_20160
BPRO: PMF13cell1_04189(gcdB)
HSD: SD1D_0451 SD1D_1113(gcdB)
EHL: EHLA_2083
EAC: EAL2_808p06910(gcdB)
CST: CLOST_0945(oadB)
OVA: OBV_10930
BPRM: CL3_29880
CBAR: PATL70BA_0283(oadB)
TTE: TTE0252(OadB) TTE1215(OadB2) TTE1798(OadB3)
THX: Thet_1086
TKI: TKV_c02030(gcdB)
TAE: TepiRe1_1424(gcdB)
CSC: Csac_2482
TSH: Tsac_2164
PED: ING2D1G_1321(gcdB1) ING2D1G_1425(gcdB3)
PHAR: NCTC13077_00173(gcdB)
VPR: Vpar_1240
VRM: 44547418_01322(gcdB)
VDN: NCTC11831_00635(gcdB)
MHG: MHY_07190
STED: SPTER_14190(gcdB)
AIN: Acin_0298(oadB)
PFAC: PFJ30894_00493(madB) PFJ30894_00913(gcdB_1) PFJ30894_00917(gcdB_2)
ERH: ERH_0758(oadB)
MGG: MPLG2_1841(gcdB)
RCA: Rcas_0953
ATM: ANT_05830(mmdB)
DFC: DFI_10225
OBG: Verru16b_01940(madB)
CAA: Caka_0796
AMU: Amuc_0204
AGL: PYTT_0610
IPA: Isop_1585
KST: KSMBR1_1801(mmdB)
PBU: L21SP3_02220(gcdB)
PBP: STSP1_01241(gcdB)
PBAS: SMSP2_02860(gcdB)
TPA: TP_0057
TPW: TPANIC_0057(oadB)
TPP: TPASS_0057(oadB)
TPU: TPADAL_0057(oadB)
TPO: TPAMA_0057(oadB)
TPC: TPECDC2_0057(oadB)
TPG: TPEGAU_0057(oadB)
TPM: TPESAMD_0057(oadB)
TPB: TPFB_0057(oadB)
TPL: TPCCA_0057(oadB)
TPED: TPE_1044
BIP: Bint_1369 Bint_2655(oadB)
FNU: FN0201
FSC: FSU_2086
BOA: Bovatus_01771(gcdB_1) Bovatus_01782(gcdB_2) Bovatus_04664(madB)
BCEL: BcellWH2_01306(gcdB_1) BcellWH2_03043(madB) BcellWH2_04425(gcdB_2)
PGI: PG_1608(mmdB)
PGN: PGN_0504
PGT: PGTDC60_0691(mmdB)
PCRE: NCTC12858_00696(gcdB)
PMUC: ING2E5A_1041(oadB2-1) ING2E5A_1042(oadB2-2) ING2E5A_1825(oadB)
TFO: BFO_0962(oadB)
APS: CFPG_533
PRU: PRU_1644
AFD: Alfi_2937
BACC: BRDCF_p1211(gcdB)
BLQ: L21SP5_03928(gcdB)
MBAS: ALGA_0600
PPH: Ppha_0944
PAA: Paes_0917
PROC: Ptc2401_01012(gcdB)
CTS: Ctha_0175
IAL: IALB_1429(oadB)
MRO: MROS_0647
TMA: TM0880
TMW: THMA_0902
TMQ: THMB_0902
TMX: THMC_0902
TPT: Tpet_0047
TRQ: TRQ2_0047
TNA: CTN_1696
TNP: Tnap_0047
TLE: Tlet_0920
TME: Tmel_1898
TAF: THA_192
THER: Y592_01035
PMO: Pmob_1666
MARN: LN42_09035
DTN: DTL3_1241(oadB)
KOL: Kole_1742
MINF: MESINF_1656(gcdB) MESINF_2159(gcdB)
CEX: CSE_10380
CABY: Cabys_114
AFU: AF_2084
ABI: Aboo_1366
PHO: PH1283(PH1283)
PAB: PAB1772
PFU: PF0674
PFI: PFC_02530
PYN: PNA2_1857
PYS: Py04_0757
TKO: TK1625
TON: TON_0038
TGA: TGAM_2029(mmdB)
TSI: TSIB_1537
THE: GQS_05065
THA: TAM4_214
THM: CL1_0657
TLT: OCC_03162
THS: TES1_0182
TNU: BD01_2084
TEU: TEU_04770
PPAC: PAP_07985
SMR: Smar_1504
 » show all
Taxonomy
Reference
1  [PMID:9128730]
  Authors
Berg M, Hilbi H, Dimroth P
  Title
Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function.
  Journal
Eur J Biochem 245:103-15 (1997)
DOI:10.1111/j.1432-1033.1997.00103.x
  Sequence
Reference
2  [PMID:11902724]
  Authors
Dimroth P, Hilbi H
  Title
Enzymic and genetic basis for bacterial growth on malonate.
  Journal
Mol Microbiol 25:3-10 (1997)
DOI:10.1046/j.1365-2958.1997.4611824.x
Other DBs
ExplorEnz - The Enzyme Database: 7.2.4.1
IUBMB Enzyme Nomenclature: 7.2.4.1
ExPASy - ENZYME nomenclature database: 7.2.4.1
BRENDA, the Enzyme Database: 7.2.4.1

DBGET integrated database retrieval system