KEGG   ENZYME: 7.2.4.1Help
Entry
EC 7.2.4.1                  Enzyme                                 

Name
carboxybiotin decarboxylase;
MadB;
carboxybiotin protein decarboxylase
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to decarboxylation
BRITE hierarchy
Sysname
carboxybiotinyl-[protein] carboxy-lyase
Reaction(IUBMB)
a carboxybiotinyl-[protein] + n Na+[side 1] + H+[side 2] = CO2 + a biotinyl-[protein] + n Na+[side 2] (n = 1--2) [RN:R09509]
Reaction(KEGG)
Substrate
carboxybiotinyl-[protein] [CPD:C18047];
Na+[side 1];
H+[side 2]
Product
CO2 [CPD:C00011];
biotinyl-[protein] [CPD:C18046];
Na+[side 2] (n = 1--2)
Comment
The integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra is a component of the multienzyme complex EC 4.1.1.89, biotin-dependent malonate decarboxylase. The free energy of the decarboxylation reaction is used to pump Na+ out of the cell. The enzyme is a member of the Na+-translocating decarboxylase family, other members of which include EC 7.2.4.2 [oxaloacetate decarboxylase (Na+ extruding)] and EC 7.2.4.3 [(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)] [2].
History
EC 7.2.4.1 created 2008 as EC 4.3.99.2, transferred 2018 to EC 7.2.4.1
Orthology
K20509  carboxybiotin decarboxylase
Genes
EFE: EFER_3127
KPZ: KPNIH27_22425
KPB: FH42_14155
CAMA: F384_01170
SFO: Z042_24860
RAC: RA876_12695
APP: CAP2UW1_3917
DES: DSOUD_0389
SAT: SYN_00115 SYN_01434
RPB: RPB_3300
RPC: RPC_1055
BVR: BVIR_2317
BLAG: BLTE_21940
RCP: RCAP_rcp00132(oadB)
RRU: Rru_A1320
RRF: F11_06830
MGRY: MSR1_01310(madB)
MAGQ: MGMAQ_2139
PFT: JBW_01387
PFAC: PFJ30894_00493(madB)
OTE: Oter_3311
OBG: Verru16b_01940(madB)
BTH: BT_4415
BTHO: Btheta7330_03681(madB)
BFR: BF1137
BFS: BF9343_1004(mmdB)
BFG: BF638R_1123(mmdB)
BOA: Bovatus_04664(madB)
BCEL: BcellWH2_03043(madB)
 » show all
Taxonomy
Reference
1  [PMID:9128730]
  Authors
Berg M, Hilbi H, Dimroth P
  Title
Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function.
  Journal
Eur J Biochem 245:103-15 (1997)
DOI:10.1111/j.1432-1033.1997.00103.x
  Sequence
Reference
2  [PMID:11902724]
  Authors
Dimroth P, Hilbi H
  Title
Enzymic and genetic basis for bacterial growth on malonate.
  Journal
Mol Microbiol 25:3-10 (1997)
DOI:10.1046/j.1365-2958.1997.4611824.x
Other DBs
ExplorEnz - The Enzyme Database: 7.2.4.1
IUBMB Enzyme Nomenclature: 7.2.4.1
ExPASy - ENZYME nomenclature database: 7.2.4.1
BRENDA, the Enzyme Database: 7.2.4.1

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