KEGG   ENZYME: 7.2.4.2Help
Entry
EC 7.2.4.2                  Enzyme                                 

Name
oxaloacetate decarboxylase (Na+ extruding);
oxaloacetate beta-decarboxylase (ambiguous);
oxalacetic acid decarboxylase (ambiguous);
oxalate beta-decarboxylase (ambiguous);
oxaloacetate carboxy-lyase (ambiguous)
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to decarboxylation
BRITE hierarchy
Sysname
oxaloacetate carboxy-lyase (pyruvate-forming; Na+-extruding)
Reaction(IUBMB)
oxaloacetate + 2 Na+[side 1] = pyruvate + CO2 + 2 Na+[side 2] [RN:R12212]
Reaction(KEGG)
Substrate
oxaloacetate [CPD:C00036];
Na+[side 1]
Product
pyruvate [CPD:C00022];
CO2 [CPD:C00011];
Na+[side 2]
Comment
The enzyme from the bacterium Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is accompanied by the extrusion of two sodium ions from cells. Some animal enzymes require Mn2+. Differs from EC 4.1.1.112 (oxaloacetate decarboxylase) for which there is no evidence for involvement in Na+ transport.
History
EC 7.2.4.2 created 1961 as EC 4.1.1.3, modified 1986, modified 2000, transferred 2018 to EC 7.2.4.2
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Orthology
K01571  oxaloacetate decarboxylase (Na+ extruding), alpha subunit
K01572  oxaloacetate decarboxylase (Na+ extruding), beta subunit
K01573  oxaloacetate decarboxylase (Na+ extruding), gamma subunit
Genes
EFE: EFER_0028(oadB) EFER_0029(oadA) EFER_0030(oadG)
STY: STY0063(oadB) STY0064(oadA) STY0065(oadG) STY3531(oadB) STY3532(oadA) STY3533(oadG)
STT: t0056(oadB) t0057(oadA) t0058(oadG) t3266(oadB) t3267(oadA) t3268(oadG)
SEX: STBHUCCB_34540 STBHUCCB_34550 STBHUCCB_34560 STBHUCCB_650 STBHUCCB_660 STBHUCCB_670
SENT: TY21A_00290 TY21A_00295 TY21A_00300 TY21A_16565 TY21A_16570 TY21A_16575
STM: STM0054 STM0055 STM0056 STM0766(dcoC) STM0768(dcoB) STM3351(oadB) STM3352(oadA) STM3353(oadG)
SEO: STM14_0064 STM14_0065 STM14_0066 STM14_0890(dcoC) STM14_0892(dcoB) STM14_4043(oadB) STM14_4044(oadA) STM14_4045(oadG)
SEV: STMMW_00551 STMMW_00561 STMMW_00571 STMMW_08181 STMMW_08191 STMMW_08201 STMMW_33501 STMMW_33511
SEY: SL1344_0055 SL1344_0056 SL1344_0057(oadG) SL1344_0743(dcoC) SL1344_0744(dcoA) SL1344_0745(dcoB) SL1344_3323(oadB2) SL1344_3324(oadA2) SL1344_3325
SEM: STMDT12_C00550 STMDT12_C00560 STMDT12_C00570 STMDT12_C08190 STMDT12_C08200 STMDT12_C08210 STMDT12_C34090 STMDT12_C34100 STMDT12_C34110
SEF: UMN798_0060(oadB2) UMN798_0061(oadB2) UMN798_0062(oadA2) UMN798_0063(oadG) UMN798_0831(oadG2) UMN798_0832(oadA2) UMN798_0833(oadB2) UMN798_3643(oadB2) UMN798_3646
SEND: DT104_00551(oadB2) DT104_07831(dcoA) DT104_07841(dcoB) DT104_33441 DT104_33451(oadA2)
SPT: SPA0055(oadB) SPA0056(oadA) SPA0057(oadG) SPA3218(oadB) SPA3219(oadA) SPA3220(oadG)
SEI: SPC_0058(oadB) SPC_0059(oadA) SPC_0060(oadG) SPC_0762(oadG) SPC_0763(oadA) SPC_0764(oadB) SPC_3421(oadB) SPC_3422(oadA) SPC_3423(oadG)
SEC: SCH_0048(oadB) SCH_0049(oadA) SCH_0050(oag3) SCH_0764(oadG) SCH_0765(oadA) SCH_0766(oadB) SCH_3289(oadB) SCH_3290(oadA) SCH_3291(oadG)
SEG: SG0057 SG0058 SG0059 SG0744(oadG2) SG0745(oadA2) SG0746(oadB2) SG3241(oadB3) SG3242 SG3243
KPU: KP1_4950(oadB) KP1_4952(oadA) KP1_4953(oadC)
KPT: VK055_2543(oadG) VK055_2544(oadA) VK055_2545(oadB) VK055_3839(oadG2) VK055_3840(oadA2) VK055_3841(oadB2)
KPE: KPK_0483(oadG_2) KPK_0484(oadA_2) KPK_0485(oadB_2) KPK_4717(oadG_1) KPK_4718(oadA_1) KPK_4719(oadB_1)
KPX: PMK1_01144(oadB) PMK1_01145 PMK1_01146(oadG)
KPNK: BN49_0482(oadG) BN49_0483(dcoA) BN49_0484(oadB_C) BN49_4308(oadG2) BN49_4309(oadA) BN49_4310(oadB_N) BN49_4529
HDU: HD_0782(oadB) HD_0783(oadA) HD_0784(oadG)
HPAZ: K756_01235
HSO: HS_0201(oadG) HS_0202(oadA) HS_0203(oadB)
PMV: PMCN06_1679(oadG) PMCN06_1680(oadA) PMCN06_1681(oadB)
PMP: Pmu_16720(oadG) Pmu_16730(oadA) Pmu_16740(oadB)
PMUL: DR93_275 DR93_276(oadA) DR93_277(oadB)
PDAG: 4362423_01741(oadG) 4362423_01742(oadA) 4362423_01743(oadB)
MSU: MS0038(oadB) MS0039(oadA) MS0040(oadG)
MHX: MHH_c10410(oadB) MHH_c10420(oadA) MHH_c10430(oadG)
APL: APL_1375(oadG) APL_1376(oadA) APL_1377(oadB)
APJ: APJL_1393 APJL_1394(oadA) APJL_1395(oadB)
APA: APP7_1426(oadG) APP7_1427(oadA) APP7_1428(oadB)
RPNE: NCTC8284_00504(oadB) NCTC8284_00505(oadA_1) NCTC8284_00506(oadA_2)
VCR: VC395_0566 VC395_0567(oadA-1) VC395_0568(oadB-1) VC395_0809(oadB-2) VC395_0810(oadA-2) VC395_0811
VCM: VCM66_0507 VCM66_0508(oadA-1) VCM66_0509(oadB-1) VCM66_0750(oadB-2) VCM66_0751(oadA-2) VCM66_0752
VNI: VIBNI_A0153(oadA) VIBNI_A0154(oadB2)
VSC: VSVS12_02745(oadB) VSVS12_02746(oadA) VSVS12_02747(oadG)
VTA: A0109(oadG) A0110(oadA) A0111(oadB) B0177(oadB) B0178(oadA)
VFI: VF_0539(oadA) VF_0540(oadB) VF_2592(oadC)
PPR: PBPRA2298(T3267) PBPRA2299(T3266) PBPRA3050(T3266) PBPRA3051(HD0783) PBPRA3052
SVO: SVI_3159(oadB) SVI_3160(oadA) SVI_3161(oadG)
ILO: IL1734(oadB) IL1735(oadA) IL1736(oadG)
CPS: CPS_1048(oadG) CPS_1049(oadA) CPS_1050(oadB)
PHA: PSHAa0538(oadG) PSHAa0539(oadA) PSHAa0540(oadB)
PSM: PSM_A0585(oadG) PSM_A0586(oadA) PSM_A0587(oadB)
PTN: PTRA_a0609(oadG) PTRA_a0611(oadA) PTRA_a0612(oadB)
PEA: PESP_a0733(oadG) PESP_a0735(oadA) PESP_a0737(oadB)
PSPO: PSPO_a2228(oadB) PSPO_a2229(oadA) PSPO_a2230
PART: PARC_a3300(oadB) PARC_a3301(oadA) PARC_a3302(oadG)
PTU: PTUN_a1099(oadG) PTUN_a1101(oadA) PTUN_a1102(oadB)
PNG: PNIG_a0649(oadG) PNIG_a0651(oadA) PNIG_a0652(oadB)
PTD: PTET_a0647(oadG) PTET_a0648(oadA) PTET_a0649(oadB)
MBS: MRBBS_1499(oadG) MRBBS_1500(oadA1) MRBBS_1501(oadB)
GNI: GNIT_1387(pycB) GNIT_2323(oadB) GNIT_2324(oadA) GNIT_2325(oadG)
SALH: HMF8227_02229(oadB) HMF8227_02230(oadA) HMF8227_02231(oadG)
MCA: MCA2479(oadB) MCA2480(oadA) MCA2481(oadC)
MAH: MEALZ_0543(oadB) MEALZ_0544(oadA) MEALZ_2663
CZA: CYCME_1869(oadB) CYCME_1870(oadA) CYCME_1871(oadG)
HEL: HELO_3734(oadB) HELO_3735(oadA) HELO_3736(oadC)
HBE: BEI_3145(oadB) BEI_3146(oadA) BEI_3147(oadG)
ABO: ABO_0843(oadG) ABO_0844(oadA) ABO_0845(oadB)
ADI: B5T_01559 B5T_01560(oadA) B5T_01561(oadB)
OAI: OLEAN_C28130(oadB) OLEAN_C28140(oadA) OLEAN_C28150(oadG)
VOK: COSY_0772(oadB) COSY_0773(oadA)
EBH: BSEPE_1238(oadB) BSEPE_1239(oadA) BSEPE_1240(oadC)
ENM: EBS_1205(oadB) EBS_1206 EBS_1207(oadC)
BPE: BP0884
BPC: BPTD_0880
BPER: BN118_1464
BPET: B1917_2940
BPEU: Q425_8190
BPA: BPP2170
BPAR: BN117_1329
BBR: BB1567
RGE: RGE_11560
EBA: ebA314(xccA)
TCL: Tchl_1582
CPIN: CPIN18020_1008(oadB) CPIN18020_1010(oadG)
AHS: AHALO_1371(oadB) AHALO_1373(oadG)
GLO: Glov_1820
GBM: Gbem_1454(oadA)
GEO: Geob_0239(oadA)
GEM: GM21_2799
DPS: DP0687
DSF: UWK_01573
DOL: Dole_2282
DML: Dmul_03490(oadB1) Dmul_10450(oadB2) Dmul_25040(gcdB)
DAL: Dalk_1191
DAT: HRM2_06280(oadB1) HRM2_38530(oadB2) HRM2_38660(oadB3)
DTO: TOL2_C10000(oadB)
SAT: SYN_01431
DBR: Deba_2621
RSU: NHU_02470
RHC: RGUI_1051
NAR: Saro_1859
SMAZ: LH19_02180
SPHD: HY78_18135
SSY: SLG_06500
AAY: WYH_03204(cfiA)
ALB: AEB_P1341
RRF: F11_18790
SPZ: M5005_Spy0894(oadA2) M5005_Spy0903(oadB) M5005_Spy0909(oadA1)
SPYM: M1GAS476_0950(oadA2) M1GAS476_0959(oadB) M1GAS476_0965(oadA1)
SPYA: A20_0931(pycB) A20_0940(gcdB) A20_0946(pycB)
SPK: MGAS9429_Spy1011(oadA1)
STG: MGAS15252_0892(oadA.1) MGAS15252_0901(oadB.2) MGAS15252_0907(oadA.2)
STX: MGAS1882_0887(oadA.1) MGAS1882_0896(oadB.2) MGAS1882_0902(oadA.2)
SMU: SMU_1017(oadB) SMU_1023(pycB)
SMC: SmuNN2025_1000(pycB) SmuNN2025_1006(oadB)
SMJ: SMULJ23_1009(pycB) SMULJ23_1015(oadB)
SMUA: SMUFR_0887(oadB) SMUFR_0892(oadA)
SEZ: Sez_0992(oadB)
SEZO: SeseC_01292(oadB) SeseC_01300(pycB)
SUB: SUB1584 SUB1591(gcdB)
SDS: SDEG_0982(oadA1) SDEG_0989(oadB) SDEG_0999(oadA2)
SDC: SDSE_1011(oadA) SDSE_1018(oadB) SDSE_1028
STK: STP_0112(gcdB) STP_0118
LSA: LCA_1222(oadA) LCA_1229(oadB)
LCB: LCABL_20790(oadA) LCABL_20860(oadB)
LCW: BN194_20290(pycB) BN194_20360(gcdB)
LRH: LGG_01912(oadA) LGG_01918(oadB)
LRL: LC705_01900(oadA) LC705_01906(oadB)
EFL: EF62_0376(oadA) EF62_0383(oadD)
EFI: OG1RF_12562(oadA) OG1RF_12569(gcdB)
EFS: EFS1_2717(oadA) EFS1_2724(oadB)
EFN: DENG_03209(oadA) DENG_03217(oadB)
EMU: EMQU_1781 EMQU_1788(gcdB)
THL: TEH_07910
CRN: CAR_c13490(oadB) CAR_c13520(oadA)
CARC: NY10_727
CACE: CACET_c19570(pycB) CACET_c36760(gcdB)
ASM: MOUSESFB_1096(oadB) MOUSESFB_1099(pycB)
ASB: RATSFB_1016(oadB) RATSFB_1019(pycB)
HSC: HVS_08280 HVS_11090(gcdB2)
CCE: Ccel_1736
CSS: Cst_c06330(gcdB) Cst_c11010(pycB) Cst_c12080(oadB)
CSD: Clst_0601(oadB1) Clst_1052(oadA) Clst_1166(oadB2)
ESR: ES1_14170
ESU: EUS_07390
RUS: RBI_I01165(gcdB) RBI_I01193(oadA)
BPB: bpr_I1229 bpr_I1230(oadA)
HSD: SD1D_0451 SD1D_1113(gcdB) SD1D_1114(pycB)
ERT: EUR_12060
ERA: ERE_26940
EAC: EAL2_808p06910(gcdB) EAL2_808p06940(pycB)
SWO: Swol_0558
SLP: Slip_0422
DSY: DSY2367
DHD: Dhaf_3508
DRM: Dred_1064
DAE: Dtox_2603
PTH: PTH_1174
DAU: Daud_1015
HMO: HM1_0282(oadA)
CTHM: CFE_0943
TTE: TTE0252(OadB) TTE1208(PycA) TTE1336(PycA2)
TIT: Thit_1131
TKI: TKV_c02030(gcdB) TKV_c12580(pycB)
CHY: CHY_1999(oadA)
MTA: Moth_1525
ADG: Adeg_1284
ATE: Athe_1319
TTM: Tthe_1352
PED: ING2D1G_0482(pycB) ING2D1G_1321(gcdB1)
VPR: Vpar_0396
MED: MELS_0064
MHG: MHY_24950
AIN: Acin_0943(oadA)
ERH: ERH_0755(oadA) ERH_0758(oadB)
MTHN: 4412656_00709(cfiA)
CGV: CGLAU_03210(cfiA)
ROP: ROP_29690
MGG: MPLG2_1841(gcdB)
BSD: BLASA_1293(xccA)
RXY: Rxyl_1571
ELE: Elen_2542
GPA: GPA_07910
AEQ: AEQU_0607
CBAC: JI75_08470
GVI: gll0879
GLJ: GKIL_2432(pycB)
RCA: Rcas_0953
TRO: trd_1683
STI: Sthe_2821
ATM: ANT_05830(mmdB)
DFC: DFI_10225
OTE: Oter_3314
CAA: Caka_0796
AMU: Amuc_0204
AGL: PYTT_0610
IPA: Isop_1585
KST: KSMBR1_1801(mmdB)
TPW: TPANIC_0055(oadG) TPANIC_0056(oadA) TPANIC_0057(oadB)
TPP: TPASS_0056(oadA) TPASS_0057(oadB)
TPU: TPADAL_0055(oadG) TPADAL_0056(oadA) TPADAL_0057(oadB)
TPO: TPAMA_0055(oadG) TPAMA_0056(oadA) TPAMA_0057(oadB)
TPC: TPECDC2_0055(oadG) TPECDC2_0056(oadA) TPECDC2_0057(oadB)
TPG: TPEGAU_0055(oadG) TPEGAU_0056(oadA) TPEGAU_0057(oadB)
TPM: TPESAMD_0055(oadG) TPESAMD_0056(oadA) TPESAMD_0057(oadB)
TPB: TPFB_0055(oadG) TPFB_0056(oadA) TPFB_0057(oadB)
TPL: TPCCA_0055(oadG) TPCCA_0056(oadA) TPCCA_0057(oadB)
FNU: FN1376
LBA: Lebu_2280
SBR: SY1_14950
FSC: FSU_2086
BACC: BRDCF_p1211(gcdB)
PGN: PGN_0504
PGT: PGTDC60_0691(mmdB)
PCRE: NCTC12858_00696(gcdB)
PMUC: ING2E5A_1041(oadB2-1) ING2E5A_1042(oadB2-2) ING2E5A_1825(oadB) ING2E5A_1827(4.1.1.3)
TFO: BFO_0962(oadB)
APS: CFPG_533
PRU: PRU_1644
AFD: Alfi_2937
BLQ: L21SP5_03928(gcdB)
PPH: Ppha_0944
PAA: Paes_0917
CTS: Ctha_0175
IAL: IALB_1429(oadB)
MRO: MROS_0647
DTN: DTL3_1241(oadB) DTL3_1286(pycB)
CEX: CSE_10380
CABY: Cabys_114
ABI: Aboo_1366
PHO: PH1283(PH1283)
PAB: PAB1772
PFU: PF0674
PFI: PFC_02530
PYN: PNA2_1857
PYS: Py04_0757
TKO: TK1625
TON: TON_0038
TGA: TGAM_2029(mmdB)
TSI: TSIB_1537
THE: GQS_05065
THA: TAM4_214
THM: CL1_0657
TLT: OCC_03162
THS: TES1_0182
TNU: BD01_2084
TEU: TEU_04770
PPAC: PAP_07985
 » show all
Taxonomy
Reference
1  [PMID:7016536]
  Authors
Dimroth P.
  Title
Characterization of a membrane-bound biotin-containing enzyme: oxaloacetate decarboxylase from Klebsiella aerogenes.
  Journal
Eur J Biochem 115:353-8 (1981)
DOI:10.1111/j.1432-1033.1981.tb05245.x
Reference
2  [PMID:7037395]
  Authors
Dimroth P.
  Title
The role of biotin and sodium in the decarboxylation of oxaloacetate by the membrane-bound oxaloacetate decarboxylase from Klebsiella aerogenes.
  Journal
Eur J Biochem 121:435-41 (1982)
DOI:10.1111/j.1432-1033.1982.tb05806.x
Other DBs
ExplorEnz - The Enzyme Database: 7.2.4.2
IUBMB Enzyme Nomenclature: 7.2.4.2
ExPASy - ENZYME nomenclature database: 7.2.4.2
BRENDA, the Enzyme Database: 7.2.4.2
CAS: 9024-98-0

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