KEGG   ENZYME: 7.2.4.3
Entry
EC 7.2.4.3                  Enzyme                                 

Name
(S)-methylmalonyl-CoA decarboxylase (sodium-transporting);
methylmalonyl-coenzyme A decarboxylase (ambiguous);
(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase (incorrect);
(S)-methylmalonyl-CoA carboxy-lyase (ambiguous)
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to decarboxylation
Sysname
(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming, sodium-transporting)
Reaction(IUBMB)
(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] = propanoyl-CoA + CO2 + Na+[side 2]
Substrate
(S)-methylmalonyl-CoA [CPD:C00683];
Na+[side 1];
H+[side 2]
Product
propanoyl-CoA [CPD:C00100];
CO2 [CPD:C00011];
Na+[side 2]
Comment
This bacterial enzyme couples the decarboxylation of (S)-methylmalonyl-CoA to propanoyl-CoA to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis. It is a membrane-associated biotin protein and is strictly dependent on sodium ions for activity.
History
EC 7.2.4.3 created 1972 as EC 4.1.1.41, modified 1983, modified 1986, transferred 2018 to EC 7.2.4.3
Orthology
K01604  methylmalonyl-CoA decarboxylase subunit alpha
Genes
HALC: EY643_09650
AFUS: EYZ66_02425
LCJ: NCTC11976_03153(accD5_2)
LWA: SAMEA4504053_2437(accD5)
THIP: N838_05290
SOK: D0B54_05175
RPJ: N234_03250
CNC: CNE_BB2p01110 CNE_BB2p01140(pccB)
CUP: BKK80_23210
CUU: BKK79_28515
BOK: DM82_1347
BOC: BG90_3347
PPNM: LV28_12085
BPAR: BN117_1335
BPA: BPP2176
ODI: ODI_R2994
DSF: UWK_01576
DOL: Dole_0077
DML: Dmul_34120(pccB3)
DAT: HRM2_31820(pccB)
DTO: TOL2_C31280(pccB)
DLI: dnl_16500(pccB)
DMM: dnm_059090(pccB)
CCX: COCOR_04246(yngE)
SAT: SYN_01398
SFU: Sfum_1223
DBR: Deba_1493
SNO: Snov_0369
RID: RIdsm_01866(accD5_1)
SPKC: KC8_05220
SMIC: SmB9_21400
BSR: I33_2039(yngE)
BSL: A7A1_0709
BSH: BSU6051_18210(yngE)
BSUT: BSUB_01959(yngE)
BSUL: BSUA_01959(yngE)
BSUS: Q433_10760
BSQ: B657_18210(yngE)
BSX: C663_1877
BST: GYO_2189(yngE)
BLH: BaLi_c22100(yngE)
BAQ: BACAU_1790(yngE)
BYA: BANAU_1958(pccB)
BAMP: B938_09480
BAML: BAM5036_1770(yngE)
BAMA: RBAU_1808(yngE)
BAMN: BASU_1788(yngE)
BAMB: BAPNAU_1911(yngE)
BAMT: AJ82_10410
BAMY: V529_18030(yngE)
BAZ: BAMTA208_07865(yngE)
BQL: LL3_02018(yngE)
BXH: BAXH7_01602(yngE)
BQY: MUS_2187(yngE)
BAMI: KSO_010200
BAMC: U471_18880
BAMF: U722_09695
BMOJ: HC660_18760(ldeE)
BANT: A16_25840
BANR: A16R_26150
BANS: BAPAT_2446
BANV: DJ46_1333
BNC: BCN_2425
BCF: bcf_12775
BCER: BCK_22090
BTT: HD73_3471
BTHI: BTK_17110
BTM: MC28_1734
BTI: BTG_06995
BTW: BF38_3734
BWW: bwei_2475(pccB)
BMYO: BG05_3470
BMYC: DJ92_5092
BPUM: BW16_09780
BPUS: UP12_09125
BJS: MY9_1988
BMET: BMMGA3_05600(yngE)
BACW: QR42_09065
BACP: SB24_00490
BACB: OY17_12300
BACO: OXB_1947
BACY: QF06_08175
BACL: BS34A_20170(yngE)
BALM: BsLM_1931
BGY: BGLY_2307(yngE)
BFD: NCTC4823_02585(pccB)
BMEG: BG04_1206
BEO: BEH_13035
BAG: Bcoa_1875
GGH: GHH_c16200(yngE) GHH_c22190(yqjD1)
ANM: GFC28_623
AAMY: GFC30_1899
HLI: HLI_01040
VPN: A21D_03456(accD5)
PASA: BAOM_1932
PSYO: PB01_05770
BLEN: NCTC4824_02765(pccB)
ASOC: CB4_01652
AAD: TC41_2172(pccB)
EFF: skT53_11260(yngE)
SIV: SSIL_3109(pccB)
JEO: JMA_15840
PABS: JIR001_20480(pccB)
CSQ: CSCA_5294
CACE: CACET_c36790(pccB)
AOE: Clos_0440
CTH: Cthe_0699
HSC: HVS_08290
CCE: Ccel_1738
CSS: Cst_c10990(pccB)
CSD: Clst_1050
RCH: RUM_13640
FPR: FP2_06000
FPA: FPR_30100
BFI: CIY_18030
BHU: bhn_I1148
RIX: RO1_15650
RIM: ROI_21860
COO: CCU_25740
CCT: CC1_18360
ROB: CK5_25570
BPRO: PMF13cell1_04192(pccB)
CSCI: HDCHBGLK_03215(pccB)
CSO: CLS_22650
HSD: SD1D_1110(yqjD)
EHL: EHLA_2086
RTO: RTO_20130
ERT: EUR_12020
ERA: ERE_26980
CST: CLOST_0942(yqjD)
STH: STH1189
PTH: PTH_1364(MmcH)
HMO: HM1_0378(mmdA)
TMR: Tmar_0857
SAY: TPY_2612(pccB) TPY_3501(mmdA)
BPRS: CK3_31530
TTE: TTE1220(AccA) TTE2385(AccA2)
THX: Thet_2119
TIT: Thit_2053
CHY: CHY_0917(pccB)
MTA: Moth_1156
CSC: Csac_1881
ATE: Athe_1316
TTM: Tthe_0367
TSH: Tsac_0943
TAE: TepiRe1_1421(yqjD)
VPR: Vpar_1244
MED: MELS_1063
STED: SPTER_14160(pccB)
AIN: Acin_0295(pccB)
LPIL: LIP_3218
MAIC: MAIC_07930
MALV: MALV_16700
MHEV: MHEL_30070
MANY: MANY_30750
SRJ: SRO_1852
ARM: ART_3485
NDK: I601_2442
PSEE: FRP1_12895
RCA: Rcas_0950
CAP: CLDAP_07660(mmdA)
LIE: LIF_A1994
LIS: LIL_11637
LST: LSS_10723
BHY: BHWA1_02042(accA)
BRM: Bmur_1759
BPO: BP951000_0994(accA)
BPW: WESB_2322
BIP: Bint_2658(accA)
TAI: Taci_0291
TLI: Tlie_0404
SBR: SY1_11120
FSC: FSU_0058
BTH: BT_1686
BTHO: Btheta7330_01331(accD5_2)
BFR: BF3289
BFS: BF9343_3042(mmdA)
BFG: BF638R_3152(mmdA)
BXY: BXY_46860
BOA: Bovatus_01768(accD5_2)
BCEL: BcellWH2_04428(accD5_1)
BVU: BVU_2491
PGI: PG_1612(mmdA)
PGN: PGN_0500
PGT: PGTDC60_0687(mmdA)
PCAG: NCTC12856_00117(accD5)
PBT: ING2E5B_1566(PCCB)
PMUC: ING2E5A_1045(pccB_1)
PSAC: PSM36_2141(Pccb)
TFO: BFO_0965
APS: CFPG_530
PRU: PRU_1231
POC: NCTC13071_01595(accD5)
AFD: Alfi_2934
ASH: AL1_03760
BLQ: L21SP5_03509 L21SP5_03931(accD5_3)
BACC: BRDCF_p1208(pccB) BRDCF_p156(yqjD)
FLM: MY04_0931
CCH: Cag_1521
CLI: Clim_0889
PVI: Cvib_1248
PLT: Plut_1431
PPH: Ppha_0947
CTS: Ctha_0178
IAL: IALB_1432(pccB)
MRO: MROS_0644
TTK: TST_1580
TMA: TM0716
TMW: THMA_0731
TMQ: THMB_0731
TMX: THMC_0731
TPT: Tpet_0214
TRQ: TRQ2_0212
TNA: CTN_1869
TNP: Tnap_0513
TLE: Tlet_0177
TME: Tmel_0585
TAF: THA_1418
THER: Y592_06465
FNO: Fnod_1317
PMO: Pmob_0553
MARN: LN42_09870
DTN: DTL3_0600(yqjD)
KOL: Kole_1368
ASAC: ATHSA_1119
CEX: CSE_10410
CABY: Cabys_111
ALAM: RT761_00558(pccB)
AFU: AF_2217
FPL: Ferp_1833
GAC: GACE_0750
GAH: GAH_01582
PFU: PF0671
PFI: PFC_02515
PHO: PH1287(PH1287)
PAB: PAB1769
PYN: PNA2_1860
PYS: Py04_0760
TKO: TK1622
TON: TON_0041
TGA: TGAM_2026(mmdA)
TSI: TSIB_1534
THE: GQS_05050
THA: TAM4_28
THM: CL1_0654
TLT: OCC_03147
THS: TES1_0179
TNU: BD01_2081
TEU: TEU_04755
TCQ: TIRI35C_0387(pccB)
PPAC: PAP_08000
HHB: Hhub_1682(pccB2)
HHI: HAH_4372(pccB2)
NAT: NJ7G_1889
SALI: L593_13010
ABI: Aboo_1363
IAG: Igag_1839
TPE: Tpen_0156
NCV: NCAV_1606(accB)
BARC: AOA65_1608
LOKI: Lokiarch_39580(accD5)
 » show all
Reference
1  [PMID:5646172]
  Authors
Galivan JH, Allen SH.
  Title
Methylmalonyl coenzyme A decarboxylase. Its role in succinate decarboxylation by Micrococcus lactilyticus.
  Journal
J Biol Chem 243:1253-61 (1968)
Reference
2  [PMID:7070502]
  Authors
Hilpert W, Dimroth P.
  Title
Conversion of the chemical energy of methylmalonyl-CoA decarboxylation into a Na+ gradient.
  Journal
Nature 296:584-5 (1982)
DOI:10.1038/296584a0
Reference
3  [PMID:2920730]
  Authors
Hoffmann A, Hilpert W, Dimroth P.
  Title
The carboxyltransferase activity of the sodium-ion-translocating methylmalonyl-CoA decarboxylase of Veillonella alcalescens.
  Journal
Eur J Biochem 179:645-50 (1989)
DOI:10.1111/j.1432-1033.1989.tb14596.x
Reference
4  [PMID:7601825]
  Authors
Huder JB, Dimroth P
  Title
Expression of the sodium ion pump methylmalonyl-coenzyme A-decarboxylase from Veillonella parvula and of mutated enzyme specimens in Escherichia coli.
  Journal
J Bacteriol 177:3623-30 (1995)
DOI:10.1128/JB.177.13.3623-3630.1995
  Sequence
Reference
5  [PMID:9428714]
  Authors
Bott M, Pfister K, Burda P, Kalbermatter O, Woehlke G, Dimroth P
  Title
Methylmalonyl-CoA decarboxylase from Propionigenium modestum--cloning and sequencing of the structural genes and purification of the enzyme complex.
  Journal
Eur J Biochem 250:590-9 (1997)
DOI:10.1111/j.1432-1033.1997.0590a.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 7.2.4.3
IUBMB Enzyme Nomenclature: 7.2.4.3
ExPASy - ENZYME nomenclature database: 7.2.4.3
BRENDA, the Enzyme Database: 7.2.4.3
CAS: 37289-44-4

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