KEGG   ENZYME: 7.2.4.3Help
Entry
EC 7.2.4.3                  Enzyme                                 

Name
(S)-methylmalonyl-CoA decarboxylase (sodium-transporting);
methylmalonyl-coenzyme A decarboxylase (ambiguous);
(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase (incorrect);
(S)-methylmalonyl-CoA carboxy-lyase (ambiguous)
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to decarboxylation
BRITE hierarchy
Sysname
(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming, sodium-transporting)
Reaction(IUBMB)
(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] = propanoyl-CoA + CO2 + Na+[side 2]
Substrate
(S)-methylmalonyl-CoA [CPD:C00683];
Na+[side 1];
H+[side 2]
Product
propanoyl-CoA [CPD:C00100];
CO2 [CPD:C00011];
Na+[side 2]
Comment
This bacterial enzyme couples the decarboxylation of (S)-methylmalonyl-CoA to propanoyl-CoA to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis. It is a membrane-associated biotin protein and is strictly dependent on sodium ions for activity.
History
EC 7.2.4.3 created 1972 as EC 4.1.1.41, modified 1983, modified 1986, transferred 2018 to EC 7.2.4.3
Orthology
K01604  methylmalonyl-CoA decarboxylase subunit alpha
Genes
BOK: DM82_1347
BOC: BG90_3347
BUU: WS70_08465
BSTL: BBJ41_20810
PRB: X636_08485
PVE: UC34_12390
POX: MB84_16745
GSB: GSUB_14440
DPR: Despr_2362
DEO: CAY53_02900
DSF: UWK_01576
DOL: Dole_0077
DML: Dmul_34120(pccB3)
DAL: Dalk_3780
DAT: HRM2_31820(pccB)
DTO: TOL2_C31280(pccB)
SAT: SYN_01398
SFU: Sfum_1223
SMIC: SmB9_21400
GGH: GHH_c22190(yqjD1)
CSQ: CSCA_5294
CACE: CACET_c36790(pccB)
AOE: Clos_0440
CTH: Cthe_0699
HSC: HVS_08290
CCE: Ccel_1738
CSS: Cst_c10990(pccB)
CSD: Clst_1050
RCH: RUM_13640
RUS: RBI_I01191(accD)
FPR: FP2_06000
FPA: FPR_30100
BFI: CIY_18030
BHU: bhn_I1148
RIX: RO1_15650
RIM: ROI_21860
COO: CCU_25740
CCT: CC1_18360
ROB: CK5_25570
RTO: RTO_20130
BPRO: PMF13cell1_04192(pccB)
CSO: CLS_22650
HSD: SD1D_1110(yqjD)
EHL: EHLA_2086
ERT: EUR_12020
ERA: ERE_26980
CST: CLOST_0942(yqjD)
STH: STH1189
PTH: PTH_1364(MmcH)
HMO: HM1_0378(mmdA)
TMR: Tmar_0857
SAY: TPY_3501(mmdA)
CTHM: CFE_0663
BPRS: CK3_31530
TTE: TTE1220(AccA) TTE2385(AccA2)
THX: Thet_2119
TIT: Thit_2053
CHY: CHY_0917(pccB)
TAE: TepiRe1_1421(yqjD)
MTA: Moth_1156
CSC: Csac_1881
ATE: Athe_1316
TTM: Tthe_0367
TSH: Tsac_0943
VPR: Vpar_1244
MED: MELS_1063
STED: SPTER_14160(pccB)
AIN: Acin_0295(pccB)
DFO: Dform_01262(pccB)
DFC: DFI_10210
BHY: BHWA1_02042(accA)
BRM: Bmur_1759
BPO: BP951000_0994(accA)
BPW: WESB_2322
BIP: Bint_2658(accA)
TAI: Taci_0291
TLI: Tlie_0404
SBR: SY1_11120
FSC: FSU_0058
BTH: BT_1686
BTHO: Btheta7330_01331(accD5_2)
BFR: BF3289
BFS: BF9343_3042(mmdA)
BFG: BF638R_3152(mmdA)
BVU: BVU_2491
BXY: BXY_46860
BOA: Bovatus_01768(accD5_2)
BCEL: BcellWH2_04428(accD5_1)
PGI: PG_1612(mmdA)
PGN: PGN_0500
PGT: PGTDC60_0687(mmdA)
PBT: ING2E5B_1566(PCCB)
PMUC: ING2E5A_1045(pccB_1)
PDI: BDI_0163
TFO: BFO_0965
PSAC: PSM36_2141(Pccb)
APS: CFPG_530
PRU: PRU_1231
POC: NCTC13071_01595(accD5)
AFD: Alfi_2934
ASH: AL1_03760
BACC: BRDCF_p1208(pccB) BRDCF_p156(yqjD)
BLQ: L21SP5_03509 L21SP5_03931(accD5_3)
FLM: MY04_0931
CCH: Cag_1521
CLI: Clim_0889
PVI: Cvib_1248
PLT: Plut_1431
PPH: Ppha_0947
CTS: Ctha_0178
IAL: IALB_1432(pccB)
MRO: MROS_0644
TMA: TM0716
TMW: THMA_0731
TMQ: THMB_0731
TMX: THMC_0731
TPT: Tpet_0214
TRQ: TRQ2_0212
TNA: CTN_1869
TNP: Tnap_0513
TLE: Tlet_0177
TME: Tmel_0585
TAF: THA_1418
THER: Y592_06465
FNO: Fnod_1317
PMO: Pmob_0553
MARN: LN42_09870
DTN: DTL3_0600(yqjD)
KOL: Kole_1368
CEX: CSE_10410
CABY: Cabys_111
AFU: AF_2217
FPL: Ferp_1833
GAC: GACE_0750
GAH: GAH_01582
ABI: Aboo_1363
PHO: PH1287(PH1287)
PAB: PAB1769
PFU: PF0671
PFI: PFC_02515
PYN: PNA2_1860
PYS: Py04_0760
TKO: TK1622
TON: TON_0041
TGA: TGAM_2026(mmdA)
TSI: TSIB_1534
THE: GQS_05050
THA: TAM4_28
THM: CL1_0654
TLT: OCC_03147
THS: TES1_0179
TNU: BD01_2081
TEU: TEU_04755
PPAC: PAP_08000
IAG: Igag_1839
TPE: Tpen_0156
NCV: NCAV_1606(accB)
BARC: AOA65_1608
LOKI: Lokiarch_39580(accD5)
 » show all
Taxonomy
Reference
1  [PMID:5646172]
  Authors
Galivan JH, Allen SH.
  Title
Methylmalonyl coenzyme A decarboxylase. Its role in succinate decarboxylation by Micrococcus lactilyticus.
  Journal
J Biol Chem 243:1253-61 (1968)
Reference
2  [PMID:7070502]
  Authors
Hilpert W, Dimroth P.
  Title
Conversion of the chemical energy of methylmalonyl-CoA decarboxylation into a Na+ gradient.
  Journal
Nature 296:584-5 (1982)
Reference
3  [PMID:2920730]
  Authors
Hoffmann A, Hilpert W, Dimroth P.
  Title
The carboxyltransferase activity of the sodium-ion-translocating methylmalonyl-CoA decarboxylase of Veillonella alcalescens.
  Journal
Eur J Biochem 179:645-50 (1989)
DOI:10.1111/j.1432-1033.1989.tb14596.x
Reference
4  [PMID:7601825]
  Authors
Huder JB, Dimroth P
  Title
Expression of the sodium ion pump methylmalonyl-coenzyme A-decarboxylase from Veillonella parvula and of mutated enzyme specimens in Escherichia coli.
  Journal
J Bacteriol 177:3623-30 (1995)
DOI:10.1128/JB.177.13.3623-3630.1995
  Sequence
Reference
5  [PMID:9428714]
  Authors
Bott M, Pfister K, Burda P, Kalbermatter O, Woehlke G, Dimroth P
  Title
Methylmalonyl-CoA decarboxylase from Propionigenium modestum--cloning and sequencing of the structural genes and purification of the enzyme complex.
  Journal
Eur J Biochem 250:590-9 (1997)
DOI:10.1111/j.1432-1033.1997.0590a.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 7.2.4.3
IUBMB Enzyme Nomenclature: 7.2.4.3
ExPASy - ENZYME nomenclature database: 7.2.4.3
BRENDA, the Enzyme Database: 7.2.4.3
CAS: 37289-44-4

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