KEGG   ENZYME: 7.4.2.10Help
Entry
EC 7.4.2.10                 Enzyme                                 

Name
ABC-type glutathione transporter;
glutathione transporting ATPase;
glutathione ABC transporter;
gsiACD (gene names)
Class
Translocases;
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type,glutathione-importing)
Reaction(IUBMB)
ATP + H2O + glutathione-[glutathione-binding protein][side 1] = ADP + phosphate + glutathione[side 2] + [glutathione-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
glutathione-[glutathione-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
glutathione[side 2];
[glutathione-binding protein][side 1]
Comment
A prokaryotic ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli is a heterotrimeric complex that interacts with an extracytoplasmic substrate binding protein to mediate the uptake of glutathione.
History
EC 7.4.2.10 created 2019
Reference
1  [PMID:16109926]
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
  Sequence
Reference
2  [PMID:18634750]
  Authors
Moussatova A, Kandt C, O'Mara ML, Tieleman DP
  Title
ATP-binding cassette transporters in Escherichia coli.
  Journal
Biochim Biophys Acta 1778:1757-71 (2008)
Other DBs
ExplorEnz - The Enzyme Database: 7.4.2.10
IUBMB Enzyme Nomenclature: 7.4.2.10
ExPASy - ENZYME nomenclature database: 7.4.2.10
BRENDA, the Enzyme Database: 7.4.2.10

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