KEGG   ENZYME: 7.4.2.11Help
Entry
EC 7.4.2.11                 Enzyme                                 

Name
ABC-type methionine transporter;
methionine transporting ATPase;
methionine ABC transporter;
metNIQ (gene names)
Class
Translocases;
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, methionine-importing)
Reaction(IUBMB)
(1) ATP + H2O + L-methionine-[methionine-binding protein][side 1] = ADP + phosphate + L-methionine[side 2] + [methionine-binding protein][side 1] ;
(2) ATP + H2O + D-methionine-[methionine-binding protein][side 1] = ADP + phosphate + D-methionine[side 2] + [methionine-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
L-methionine-[methionine-binding protein][side 1];
D-methionine-[methionine-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
L-methionine[side 2];
[methionine-binding protein][side 1];
D-methionine[side 2]
Comment
ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and functions to import methionine. The enzyme from Escherichia coli K-12 mediates the high affinity transport of both L- and D-methionine, as well as methionine-S-oxide and N-acetyl-DL-methionine.
History
EC 7.4.2.11 created 2019
Reference
1  [PMID:12218041]
  Authors
Merlin C, Gardiner G, Durand S, Masters M
  Title
The Escherichia coli metD locus encodes an ABC transporter which includes Abc (MetN), YaeE (MetI), and YaeC (MetQ).
  Journal
J Bacteriol 184:5513-7 (2002)
DOI:10.1128/JB.184.19.5513-5517.2002
  Sequence
Reference
2  [PMID:12819857]
  Authors
Zhang Z, Feige JN, Chang AB, Anderson IJ, Brodianski VM, Vitreschak AG, Gelfand MS, Saier MH Jr
  Title
A transporter of Escherichia coli specific for L- and D-methionine is the prototype for a new family within the ABC superfamily.
  Journal
Arch Microbiol 180:88-100 (2003)
  Sequence
Reference
3  [PMID:18634750]
  Authors
Moussatova A, Kandt C, O'Mara ML, Tieleman DP
  Title
ATP-binding cassette transporters in Escherichia coli.
  Journal
Biochim Biophys Acta 1778:1757-71 (2008)
Other DBs
ExplorEnz - The Enzyme Database: 7.4.2.11
IUBMB Enzyme Nomenclature: 7.4.2.11
ExPASy - ENZYME nomenclature database: 7.4.2.11
BRENDA, the Enzyme Database: 7.4.2.11

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