KEGG   ENZYME: 7.4.2.12Help
Entry
EC 7.4.2.12                 Enzyme                                 

Name
ABC-type cystine transporter;
cystine transporting ATPase;
cystine ABC transporter
Class
Translocases;
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, cystine-importing)
Reaction(IUBMB)
(1) ATP + H2O + L-cystine-[cystine-binding protein][side 1] = ADP + phosphate + L-cystine[side 2] + [cystine-binding protein][side 1] ;
(2) ATP + H2O + D-cystine-[cystine-binding protein][side 1] = ADP + phosphate + D-cystine[side 2] + [cystine-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
L-cystine-[cystine-binding protein][side 1];
D-cystine-[cystine-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
L-cystine[side 2];
[cystine-binding protein][side 1];
D-cystine[side 2]
Comment
ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity import of trace cystine. The enzyme from Escherichia coli K-12 can import both isomers of cystine and a variety of related molecules including djenkolate, lanthionine, diaminopimelate and homocystine.
History
EC 7.4.2.12 created 2019
Reference
1  [PMID:4564569]
  Authors
Berger EA, Heppel LA
  Title
A binding protein involved in the transport of cystine and diaminopimelic acid in Escherichia coli.
  Journal
J Biol Chem 247:7684-94 (1972)
Reference
2  [PMID:26350134]
  Authors
Chonoles Imlay KR, Korshunov S, Imlay JA
  Title
Physiological Roles and Adverse Effects of the Two Cystine Importers of Escherichia coli.
  Journal
J Bacteriol 197:3629-44 (2015)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 7.4.2.12
IUBMB Enzyme Nomenclature: 7.4.2.12
ExPASy - ENZYME nomenclature database: 7.4.2.12
BRENDA, the Enzyme Database: 7.4.2.12

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