EC 18.104.22.168 Enzyme
ABC-type cystine transporter;
cystine transporting ATPase;
cystine ABC transporter
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
ATP phosphohydrolase (ABC-type, cystine-importing)
(1) ATP + H2O + L-cystine-[cystine-binding protein][side 1] = ADP + phosphate + L-cystine[side 2] + [cystine-binding protein][side 1] ;
(2) ATP + H2O + D-cystine-[cystine-binding protein][side 1] = ADP + phosphate + D-cystine[side 2] + [cystine-binding protein][side 1]
L-cystine-[cystine-binding protein][side 1];
D-cystine-[cystine-binding protein][side 1]
[cystine-binding protein][side 1];
ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity import of trace cystine. The enzyme from Escherichia coli K-12 can import both isomers of cystine and a variety of related molecules including djenkolate, lanthionine, diaminopimelate and homocystine.
EC 22.214.171.124 created 2019
Berger EA, Heppel LA
A binding protein involved in the transport of cystine and diaminopimelic acid in Escherichia coli.
J Biol Chem 247:7684-94 (1972)
Chonoles Imlay KR, Korshunov S, Imlay JA
Physiological Roles and Adverse Effects of the Two Cystine Importers of Escherichia coli.
J Bacteriol 197:3629-44 (2015)
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
No link information was found.
integrated database retrieval system