KEGG   ENZYME: 7.4.2.2Help
Entry
EC 7.4.2.2                  Enzyme                                 

Name
ABC-type nonpolar-amino-acid transporter;
nonpolar-amino-acid-transporting ATPase
Class
Translocases;
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, nonpolar-amino-acid-importing)
Reaction(IUBMB)
ATP + H2O + nonpolar amino acid-[nonpolar amino acid-binding protein][side 1] = ADP + phosphate + nonpolar amino acid[side 2] + [nonpolar amino acid-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
nonpolar amino acid-[nonpolar amino acid-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
nonpolar amino acid[side 2];
[nonpolar amino acid-binding protein][side 1]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein. This entry comprises enzymes that import Leu, Ile and Val.
History
EC 7.4.2.2 created 2000 as EC 3.6.3.22, transferred 2018 to EC 7.4.2.2
Orthology
K10822  nonpolar-amino-acid-transporting ATPase
Genes
REH: H16_A1244(h16_A1244) H16_A1245(h16_A1245) H16_A1542(h16_A1542)
Taxonomy
Reference
1  [PMID:7569321]
  Authors
Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr.
  Title
Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases.
  Journal
Res Microbiol 146:271-8 (1995)
DOI:10.1016/0923-2508(96)81050-3
Reference
2  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv Microb Physiol 40:81-136 (1998)
Reference
3
  Authors
Griffiths, J.K. and Sansom, C.E.
  Title
The Transporter Factsbook, Academic Press, San Diego, 1998.
Other DBs
ExplorEnz - The Enzyme Database: 7.4.2.2
IUBMB Enzyme Nomenclature: 7.4.2.2
ExPASy - ENZYME nomenclature database: 7.4.2.2
BRENDA, the Enzyme Database: 7.4.2.2

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