KEGG   ENZYME: 7.4.2.6Help
Entry
EC 7.4.2.6                  Enzyme                                 

Name
ABC-type oligopeptide transporter;
oligopeptide permease;
OppBCDF;
oligopeptide ABC transporter;
oligopeptide-transporting ATPase
Class
Translocases;
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, oligopeptide-importing)
Reaction(IUBMB)
ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1] = ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
oligopeptide-[oligopeptide-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
oligopeptide[side 2];
[oligopeptide-binding protein][side 1]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of oligopeptides of varying nature. The binding protein determines the specificity of the system. cf. EC 7.4.2.9, ABC-type dipeptide transporter.
History
EC 7.4.2.6 created 2000 as EC 3.6.3.23, transferred 2018 to EC 7.4.2.6
Reference
1  [PMID:7569321]
  Authors
Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr.
  Title
Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases.
  Journal
Res Microbiol 146:271-8 (1995)
DOI:10.1016/0923-2508(96)81050-3
Reference
2  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv Microb Physiol 40:81-136 (1998)
Reference
3
  Authors
Griffiths, J.K. and Sansom, C.E.
  Title
The Transporter Factsbook, Academic Press, San Diego, 1998.
Reference
4  [PMID:1738314]
  Authors
Pearce SR, Mimmack ML, Gallagher MP, Gileadi U, Hyde SC, Higgins CF.
  Title
Membrane topology of the integral membrane components, OppB and OppC, of the oligopeptide permease of Salmonella typhimurium.
  Journal
Mol Microbiol 6:47-57 (1992)
DOI:10.1111/j.1365-2958.1992.tb00836.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 7.4.2.6
IUBMB Enzyme Nomenclature: 7.4.2.6
ExPASy - ENZYME nomenclature database: 7.4.2.6
BRENDA, the Enzyme Database: 7.4.2.6

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