KEGG   ENZYME: 7.4.2.9Help
Entry
EC 7.4.2.9                  Enzyme                                 

Name
ABC-type dipeptide transporter;
dipeptide transporting ATPase;
dipeptide ABC transporter;
dppBCDF (gene names)
Class
Translocases;
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, dipeptide-transporting)
Reaction(IUBMB)
ATP + H2O + a dipeptide-[dipeptide-binding protein][side 1] = ADP + phosphate + a dipeptide[side 2] + [dipeptide-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
dipeptide-[dipeptide-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
dipeptide[side 2];
[dipeptide-binding protein][side 1]
Comment
ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the uptake of di- and tripeptides. The enzyme from Pseudomonas aeruginosa can interact with five different substrate binding proteins.
History
EC 7.4.2.9 created 2018
Reference
1  [PMID:1956284]
  Authors
Abouhamad WN, Manson M, Gibson MM, Higgins CF
  Title
Peptide transport and chemotaxis in Escherichia coli and Salmonella typhimurium:  characterization of the dipeptide permease (Dpp) and the dipeptide-binding protein.
  Journal
Mol Microbiol 5:1035-47 (1991)
Reference
2  [PMID:11409543]
  Authors
Sanz Y, Lanfermeijer FC, Renault P, Bolotin A, Konings WN, Poolman B
  Title
Genetic and functional characterization of dpp genes encoding a dipeptide transport system in Lactococcus lactis.
  Journal
Arch Microbiol 175:334-43 (2001)
Reference
3  [PMID:23385461]
  Authors
Li X, Zhuo W, Yu J, Ge J, Gu J, Feng Y, Yang M, Wang L, Wang N
  Title
Structure of the nucleotide-binding domain of a dipeptide ABC transporter reveals a novel iron-sulfur cluster-binding domain.
  Journal
Acta Crystallogr D Biol Crystallogr 69:256-65 (2013)
DOI:10.1107/S0907444912045180
Reference
4  [PMID:25338022]
  Authors
Pletzer D, Lafon C, Braun Y, Kohler T, Page MG, Mourez M, Weingart H
  Title
High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in Pseudomonas aeruginosa.
  Journal
PLoS One 9:e111311 (2014)
DOI:10.1371/journal.pone.0111311
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 7.4.2.9
IUBMB Enzyme Nomenclature: 7.4.2.9
ExPASy - ENZYME nomenclature database: 7.4.2.9
BRENDA, the Enzyme Database: 7.4.2.9

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