KEGG   ENZYME: 7.5.2.2Help
Entry
EC 7.5.2.2                  Enzyme                                 

Name
ABC-type oligosaccharide transporter;
oligosaccharide-transporting ATPase
Class
Translocases;
Catalysing the translocation of carbohydrates and their derivatives;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, oligosaccharide-importing)
Reaction(IUBMB)
ATP + H2O + oligosaccharide-[oligosaccharide-binding protein][side 1] = ADP + phosphate + oligosaccharide[side 2] + [oligosaccharide-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
oligosaccharide-[oligosaccharide-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
oligosaccharide[side 2];
[oligosaccharide-binding protein][side 1]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of lactose, melibiose and raffinose.
History
EC 7.5.2.2 created 2000 as EC 3.6.3.18, transferred 2018 to EC 7.5.2.2
Reference
1  [PMID:1282354]
  Authors
Higgins CF.
  Title
ABC transporters: from microorganisms to man.
  Journal
Annu Rev Cell Biol 8:67-113 (1992)
DOI:10.1146/annurev.cb.08.110192.000435
Reference
2  [PMID:1630315]
  Authors
Williams SG, Greenwood JA, Jones CW.
  Title
Molecular analysis of the lac operon encoding the binding-protein-dependent lactose transport system and beta-galactosidase in Agrobacterium radiobacter.
  Journal
Mol Microbiol 6:1755-68 (1992)
DOI:10.1111/j.1365-2958.1992.tb01348.x
  Sequence
Reference
3  [PMID:8336670]
  Authors
Tam R, Saier MH Jr.
  Title
Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria.
  Journal
Microbiol Rev 57:320-46 (1993)
Reference
4  [PMID:7569321]
  Authors
Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr.
  Title
Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases.
  Journal
Res Microbiol 146:271-8 (1995)
DOI:10.1016/0923-2508(96)81050-3
Reference
5  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv Microb Physiol 40:81-136 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 7.5.2.2
IUBMB Enzyme Nomenclature: 7.5.2.2
ExPASy - ENZYME nomenclature database: 7.5.2.2
BRENDA, the Enzyme Database: 7.5.2.2

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