KEGG   ENZYME: 7.5.2.6Help
Entry
EC 7.5.2.6                  Enzyme                                 

Name
ABC-type lipid A-core oligosaccharide transporter;
MsbA;
lipid flippase;
ATP-dependent lipid A-core flippase
Class
Translocases;
Catalysing the translocation of carbohydrates and their derivatives;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, lipid A-core oligosaccharide-translocating)
Reaction(IUBMB)
ATP + H2O + lipid A-core oligosaccharide[side 1] = ADP + phosphate + lipid A-core oligosaccharide[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
lipid A-core oligosaccharide[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
lipid A-core oligosaccharide[side 2]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, best characterized from the bacterium Escherichia coli, is located in the inner membrane and mediates the movement of lipid A attached to the core oligosaccharide from the cytoplasm to the periplasmic side of the inner membrane, an important step in the lipopolysaccharide biosynthetic pathway. Not to be confused with EC 7.5.2.5, ABC-type lipopolysaccharide transporter (LptB), which is implicated in the translocation of LPS from the inner membrane to the outer membrane and acts later in the process.
History
EC 7.5.2.6 created 2018
Reference
1  [PMID:8094880]
  Authors
Karow M, Georgopoulos C
  Title
The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP-dependent translocators.
  Journal
Mol Microbiol 7:69-79 (1993)
  Sequence
[eco:b0914]
Reference
2  [PMID:9575204]
  Authors
Zhou Z, White KA, Polissi A, Georgopoulos C, Raetz CR
  Title
Function of Escherichia coli MsbA, an essential ABC family transporter, in lipid  A and phospholipid biosynthesis.
  Journal
J Biol Chem 273:12466-75 (1998)
DOI:10.1074/jbc.273.20.12466
  Sequence
[eco:b0914]
Reference
3  [PMID:27499013]
  Authors
Singh H, Velamakanni S, Deery MJ, Howard J, Wei SL, van Veen HW
  Title
ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled.
  Journal
Nat Commun 7:12387 (2016)
DOI:10.1038/ncomms12387
Other DBs
ExplorEnz - The Enzyme Database: 7.5.2.6
IUBMB Enzyme Nomenclature: 7.5.2.6
ExPASy - ENZYME nomenclature database: 7.5.2.6
BRENDA, the Enzyme Database: 7.5.2.6

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