KEGG   ENZYME: 7.6.2.16Help
Entry
EC 7.6.2.16                 Enzyme                                 

Name
ABC-type putrescine transporter;
putrescine transporting ATPase;
putrescine ABC transporter;
potFGHI (gene names)
Class
Translocases;
Catalysing the translocation of other compounds;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, putrescine-importing)
Reaction(IUBMB)
ATP + H2O + putrescine-[putrescine-binding protein][side 1] = ADP + phosphate + putrescine[side 2] + [putrescine-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
putrescine-[putrescine-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
putrescine[side 2];
[putrescine-binding protein][side 1]
Comment
ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of putrescine. Differs in specificity from EC 7.6.2.11, ABC-type polyamine transporter.
History
EC 7.6.2.16 created 2019
Reference
1  [PMID:8416922]
  Authors
Pistocchi R, Kashiwagi K, Miyamoto S, Nukui E, Sadakata Y, Kobayashi H, Igarashi K
  Title
Characteristics of the operon for a putrescine transport system that maps at 19 minutes on the Escherichia coli chromosome.
  Journal
J Biol Chem 268:146-52 (1993)
  Sequence
Reference
2  [PMID:23719730]
  Authors
Terui Y, Saroj SD, Sakamoto A, Yoshida T, Higashi K, Kurihara S, Suzuki H, Toida T, Kashiwagi K, Igarashi K
  Title
Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance in Escherichia coli.
  Journal
Amino Acids 46:661-70 (2014)
Other DBs
ExplorEnz - The Enzyme Database: 7.6.2.16
IUBMB Enzyme Nomenclature: 7.6.2.16
ExPASy - ENZYME nomenclature database: 7.6.2.16
BRENDA, the Enzyme Database: 7.6.2.16

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