KEGG   ENZYME: 7.6.2.3Help
Entry
EC 7.6.2.3                  Enzyme                                 

Name
ABC-type glutathione-S-conjugate transporter;
multidrug resistance-associated protein 1;
glutathione-S-conjugate-translocating ATPase;
MRP;
MRP1;
ABCC1 (gene name);
YBT1 (gene name);
YCF1 (gene name)
Class
Translocases;
Catalysing the translocation of other compounds;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, glutathione-S-conjugate-exporting)
Reaction(IUBMB)
ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
glutathione-S-conjugate[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
glutathione-S-conjugate[side 2]
Comment
A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
History
EC 7.6.2.3 created 2018
Orthology
K05665  ATP-binding cassette, subfamily C (CFTR/MRP), member 1
Genes
HSA: 4363(ABCC1)
PTR: 453952(ABCC1)
PPS: 100969990
GGO: 101130854
PON: 100431822(ABCC1)
NLE: 100588347 100590031 100602390(ABCC1)
MCC: 717857(ABCC1)
MCF: 102133648(ABCC1)
CSAB: 103228870(ABCC1)
RRO: 104668218(ABCC1)
RBB: 108529411(ABCC1)
CJC: 100391747(ABCC1) 100414398
SBQ: 101029348(ABCC1)
MMU: 17250(Abcc1)
MCAL: 110311227(Abcc1)
MPAH: 110329472(Abcc1)
RNO: 24565(Abcc1)
MUN: 110561236(Abcc1)
CGE: 100689208(Abcc1)
NGI: 103731543(Abcc1)
HGL: 101725452(Abcc1)
CCAN: 109697739(Abcc1)
OCU: 100345841(ABCC1)
TUP: 102470104(ABCC1)
CFA: 403453(ABCC1)
VVP: 112923232(ABCC1)
AML: 100464941(ABCC1)
UMR: 103668839(ABCC1)
UAH: 113270755(ABCC1)
ORO: 101376465(ABCC1)
FCA: 101101279(ABCC1)
PTG: 102968778(ABCC1)
PPAD: 109278375(ABCC1)
AJU: 106970556(ABCC1)
BTA: 281588(ABCC1)
BOM: 102280609(ABCC1)
BIU: 109578115(ABCC1)
BBUB: 102410242(ABCC1)
CHX: 102177770(ABCC1)
OAS: 101110991(ABCC1)
SSC: 733619(ABCC1)
CFR: 102515231(ABCC1)
CDK: 105091152(ABCC1)
BACU: 103008581(ABCC1) 103009263
LVE: 103078230(ABCC1)
OOR: 101289237(ABCC1)
DLE: 111163524(ABCC1)
PCAD: 102994606(ABCC1)
ECB: 791240(ABCC1)
EPZ: 103542517(ABCC1) 103558096
EAI: 106828820(ABCC1)
MYB: 102239517(ABCC1)
MYD: 102760334(ABCC1)
MNA: 107524383(ABCC1)
HAI: 109395236(ABCC1)
DRO: 112314786(ABCC1)
PALE: 102892429(ABCC1)
RAY: 107516824(ABCC1)
MJV: 108400896(ABCC1)
LAV: 100666408(ABCC1)
TMU: 101342579
MDO: 100023220(ABCC1)
SHR: 100932170(ABCC1)
PCW: 110218836(ABCC1)
OAA: 100087202(ABCC1)
GGA: 395416(ABCC1)
MGP: 100544305(ABCC1)
CJO: 107320624(ABCC1)
NMEL: 110406022(ABCC1)
APLA: 101802999
ACYG: 106033447(ABCC1)
TGU: 100227445
LSR: 110475561
SCAN: 103817702
GFR: 102039176(ABCC1)
FAB: 101808560(ABCC1)
PHI: 102100964(ABCC1)
PMAJ: 107211108(ABCC1)
CCAE: 111936261(ABCC1)
CCW: 104684893
ETL: 114058258
FPG: 101914887(ABCC1)
FCH: 102059643(ABCC1)
CLV: 102094737(ABCC1)
EGZ: 104126971
NNI: 104015166(ABCC1)
ACUN: 113485691(ABCC1)
PADL: 103917631(ABCC1)
ASN: 102378532
AMJ: 102573783(ABCC1)
PSS: 102444909
CMY: 102937562(ABCC1)
CPIC: 101947628(ABCC1)
ACS: 100559502(abcc1)
PVT: 110087057(ABCC1)
PBI: 103062593(ABCC1)
PMUR: 107283988(ABCC1)
TSR: 106551513(ABCC1)
PMUA: 114583978
GJA: 107109283(ABCC1)
XLA: 108701539(abcc1.L) 108701540(abcc6.L) 108702301
DRE: 100002010(abcc1) 566555(abcc6a)
CMK: 103178792(abcc1)
RTP: 109921952(abcc1) 109923955
SPU: 591344(ABCC1)
DME: Dmel_CG6214(MRP)
DER: 6542983
DSI: Dsimw501_GD23852(Dsim_GD23852)
DSR: 110183917
DPE: 6603032
DMN: 108161569
DWI: 6643888
DAZ: 108610377
DNV: 115562145
DHE: 111595812
MDE: 101899511
LCQ: 111677704
AAG: 5565387
AME: 412217
BIM: 100742783
BTER: 100646583
CCAL: 108625907
OBB: 114872159
SOC: 105197472
MPHA: 105839030
AEC: 105143093
ACEP: 105623280
PBAR: 105427107
VEM: 105569914
HST: 105192220
DQU: 106750551
CFO: 105256288
LHU: 105670386
PGC: 109855782
OBO: 105282850
PCF: 106791501
NVI: 100120375
CSOL: 105363013
MDL: 103575185
TCA: 657826
NVL: 108566785
PMAC: 106714042
PRAP: 111001117
PXY: 105391710
AGS: 114127472
RMD: 113553801
ZNE: 110828594
CEL: CELE_F57C12.4(mrp-2) CELE_F57C12.5(mrp-1)
CBR: CBG08145(Cbr-mrp-1)
EGL: EGR_09216
HMG: 100199288
CIT: 102609764
CAM: 101514243
LJA: Lj0g3v0045069.1(Lj0g3v0045069.1) Lj0g3v0275429.1(Lj0g3v0275429.1) Lj0g3v0275429.2(Lj0g3v0275429.2) Lj0g3v0306379.1(Lj0g3v0306379.1) Lj0g3v0306379.2(Lj0g3v0306379.2) Lj1g3v4528420.1(Lj1g3v4528420.1) Lj3g3v0618270.1(Lj3g3v0618270.1) Lj3g3v2317940.1(Lj3g3v2317940.1) Lj3g3v2693530.1(Lj3g3v2693530.1) Lj3g3v3247340.1(Lj3g3v3247340.1) Lj5g3v1961180.1(Lj5g3v1961180.1) Lj5g3v1961190.1(Lj5g3v1961190.1)
RCN: 112193503
HBR: 110649202
POP: 7469392
CANN: 107845301
SOE: 110792524
DOSA: Os01t0173900-01(Os01g0173900) Os01t0356400-01(Os01g0356400) Os03t0142800-01(Os03g0142800) Os04t0209300-01(Os04g0209300) Os04t0588700-01(Os04g0588700) Os05t0196100-01(Os05g0196100) Os06t0561800-00(Os06g0561800)
ATS: 109750435(LOC109750435) 109758359(LOC109758359) 109759425(LOC109759425) 109773936(LOC109773936) 109773946(LOC109773946) 109774444(LOC109774444) 109775396(LOC109775396) 109782206(LOC109782206)
DCT: 110101875
APRO: F751_6814
SCE: YDR135C(YCF1)
ERC: Ecym_4265
KMX: KLMA_10678(BPT1) KLMA_40176(YCF1)
NCS: NCAS_0B03470(NCAS0B03470)
NDI: NDAI_0J01150(NDAI0J01150)
TPF: TPHA_0C00960(TPHA0C00960) TPHA_0F00410(TPHA0F00410)
TBL: TBLA_0A03800(TBLA0A03800)
TDL: TDEL_0E05610(TDEL0E05610) TDEL_0F04300(TDEL0F04300)
KAF: KAFR_0B05630(KAFR0B05630) KAFR_0I01300(KAFR0I01300)
CAL: CAALFM_C108210CA(MLT1) CAALFM_C702330WA(YCF1) CAALFM_CR08200CA(CaO19.6382)
SLB: AWJ20_1275(YCF1) AWJ20_2293(YCF1) AWJ20_3641(YCF1) AWJ20_497(YCF1)
NCR: NCU09012
NTE: NEUTE1DRAFT122521(NEUTE1DRAFT_122521)
MGR: MGG_01674
BFU: BCIN_10g00650(Bcycf1)
MBE: MBM_00964
ANI: AN7729.2
ANG: ANI_1_480034(An03g04060)
ABE: ARB_03963
TVE: TRV_01828
PTE: PTT_16022
SPO: SPAC3F10.11c(abc2) SPBC359.05(abc3)
CNE: CNC05860
CNB: CNBC1320
ABP: AGABI1DRAFT119022(AGABI1DRAFT_119022)
ABV: AGABI2DRAFT151707(AGABI2DRAFT_151707)
MGL: MGL_0393
MRT: MRET_2214
DDI: DDB_G0284867(abcC8)
DFA: DFA_01047(abcC3) DFA_04952 DFA_06298(abcC12) DFA_06664(abcC8) DFA_06666
SMIN: v1.2.005718.t1(symbB.v1.2.005718.t1) v1.2.013973.t1(symbB.v1.2.013973.t1) v1.2.014963.t1(symbB.v1.2.014963.t1) v1.2.023547.t1(symbB.v1.2.023547.t1) v1.2.027690.t1(symbB.v1.2.027690.t1) v1.2.027690.t2(symbB.v1.2.027690.t2) v1.2.027690.t3(symbB.v1.2.027690.t3) v1.2.030730.t1(symbB.v1.2.030730.t1) v1.2.032089.t1(symbB.v1.2.032089.t1) v1.2.032880.t1(symbB.v1.2.032880.t1) v1.2.035158.t1(symbB.v1.2.035158.t1) v1.2.037762.t1(symbB.v1.2.037762.t1) v1.2.040950.t1(symbB.v1.2.040950.t1)
BEX: A11Q_576
 » show all
Taxonomy
Reference
1  [PMID:7916458]
  Authors
Zaman GJ, Flens MJ, van Leusden MR, de Haas M, Mulder HS, Lankelma J, Pinedo HM, Scheper RJ, Baas F, Broxterman HJ, et al.
  Title
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.
  Journal
Proc Natl Acad Sci U S A 91:8822-6 (1994)
DOI:10.1073/pnas.91.19.8822
  Sequence
[hsa:4363]
Reference
2  [PMID:8831715]
  Authors
Lautier D, Canitrot Y, Deeley RG, Cole SP
  Title
Multidrug resistance mediated by the multidrug resistance protein (MRP) gene.
  Journal
Biochem Pharmacol 52:967-77 (1996)
Reference
3  [PMID:8626454]
  Authors
Li ZS, Szczypka M, Lu YP, Thiele DJ, Rea PA.
  Title
The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump.
  Journal
J Biol Chem 271:6509-17 (1996)
DOI:10.1074/jbc.271.11.6509
  Sequence
[sce:YDR135C]
Reference
4  [PMID:9223346]
  Authors
Lu YP, Li ZS, Rea PA
  Title
AtMRP1 gene of Arabidopsis encodes a glutathione S-conjugate pump: isolation and  functional definition of a plant ATP-binding cassette transporter gene.
  Journal
Proc Natl Acad Sci U S A 94:8243-8 (1997)
DOI:10.1073/pnas.94.15.8243
  Sequence
[ath:AT1G30400]
Reference
5  [PMID:25281745]
  Authors
Cole SP
  Title
Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter.
  Journal
J Biol Chem 289:30880-8 (2014)
DOI:10.1074/jbc.R114.609248
Reference
6  [PMID:26227410]
  Authors
Cordente AG, Capone DL, Curtin CD
  Title
Unravelling glutathione conjugate catabolism in Saccharomyces cerevisiae: the role of glutathione/dipeptide transporters and vacuolar function in the release of volatile sulfur compounds 3-mercaptohexan-1-ol and 4-mercapto-4-methylpentan-2-one.
  Journal
Appl Microbiol Biotechnol 99:9709-22 (2015)
DOI:10.1007/s00253-015-6833-5
Other DBs
ExplorEnz - The Enzyme Database: 7.6.2.3
IUBMB Enzyme Nomenclature: 7.6.2.3
ExPASy - ENZYME nomenclature database: 7.6.2.3
BRENDA, the Enzyme Database: 7.6.2.3

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