KEGG   ENZYME: 7.6.2.4Help
Entry
EC 7.6.2.4                  Enzyme                                 

Name
ABC-type fatty-acyl-CoA transporter;
fatty-acyl-CoA-transporting ATPase
Class
Translocases;
Catalysing the translocation of other compounds;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, fatty-acyl-CoA-transporting)
Reaction(IUBMB)
ATP + H2O + fatty acyl CoA[side 1] = ADP + phosphate + fatty acyl CoA[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
fatty acyl CoA[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
fatty acyl CoA[side 2]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. An animal and yeast enzyme that transports fatty acyl CoA into and out of peroxisomes. In humans, it is associated with Zellweger's syndrome.
History
EC 7.6.2.4 created 2000 as EC 3.6.3.47, transferred 2018 to EC 7.6.2.4
Reference
1  [PMID:1968461]
  Authors
Kamijo K, Taketani S, Yokota S, Osumi T, Hashimoto T.
  Title
The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily.
  Journal
J Biol Chem 265:4534-40 (1990)
  Sequence
[rno:25270]
Reference
2  [PMID:8670886]
  Authors
Hettema EH, van Roermund CW, Distel B, van den Berg M, Vilela C, Rodrigues-Pousada C, Wanders RJ, Tabak HF.
  Title
The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae.
  Journal
EMBO J 15:3813-22 (1996)
  Sequence
Reference
3  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv Microb Physiol 40:81-136 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 7.6.2.4
IUBMB Enzyme Nomenclature: 7.6.2.4
ExPASy - ENZYME nomenclature database: 7.6.2.4
BRENDA, the Enzyme Database: 7.6.2.4

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