KEGG   ENZYME: 7.6.2.6Help
Entry
EC 7.6.2.6                  Enzyme                                 

Name
ABC-type guanine transporter;
guanine-transporting ATPase;
white (gene name);
brown (gene name)
Class
Translocases;
Catalysing the translocation of other compounds;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, guanine-importing)
Reaction(IUBMB)
ATP + H2O + guanine[side 1] = ADP + phosphate + guanine[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
guanine[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
guanine[side 2]
Comment
An ATP-binding cassette (ABC) type transporter found in insects that transports guanine and other purines into pigment granules in the eye, where they are converted to pteridine pigments. The transporter is a hererodimer composed of two different peptides, each containing one membrane-spanning and one cytoplasmic ATP-binding domain. In Drosophila, this transporter is encoded by the white and brown genes.
History
EC 7.6.2.6 created 2000 as EC 3.6.3.37, transferred 2018 to EC 7.6.2.6
Reference
1  [PMID:117796]
  Authors
Sullivan DT, Bell LA, Paton DR, Sullivan MC
  Title
Purine transport by malpighian tubules of pteridine-deficient eye color mutants of Drosophila melanogaster.
  Journal
Biochem Genet 17:565-73 (1979)
Reference
2  [PMID:3149712]
  Authors
Dreesen TD, Johnson DH, Henikoff S.
  Title
The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes.
  Journal
Mol Cell Biol 8:5206-15 (1988)
DOI:10.1128/MCB.8.12.5206
  Sequence
Reference
3  [PMID:2503416]
  Authors
Tearle RG, Belote JM, McKeown M, Baker BS, Howells AJ.
  Title
Cloning and characterization of the scarlet gene of Drosophila melanogaster.
  Journal
Genetics 122:595-606 (1989)
  Sequence
Reference
4
  Authors
Griffiths, J.K. and Sansom, C.E.
  Title
The Transporter Factsbook, Academic Press, San Diego, 1998.
Reference
5  [PMID:10407069]
  Authors
Mackenzie SM, Brooker MR, Gill TR, Cox GB, Howells AJ, Ewart GD
  Title
Mutations in the white gene of Drosophila melanogaster affecting ABC transporters that determine eye colouration.
  Journal
Biochim Biophys Acta 1419:173-85 (1999)
Other DBs
ExplorEnz - The Enzyme Database: 7.6.2.6
IUBMB Enzyme Nomenclature: 7.6.2.6
ExPASy - ENZYME nomenclature database: 7.6.2.6
BRENDA, the Enzyme Database: 7.6.2.6

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