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Entry
EC 7.6.2.8                  Enzyme                                 

Name
ABC-type vitamin B12 transporter;
BtuCDF;
vitamin B12 ABC transporter;
vitamin B12-transporting ATPase
Class
Translocases;
Catalysing the translocation of other compounds;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, vitamin B12-importing)
Reaction(IUBMB)
ATP + H2O + vitamin B12-[cobalamin-binding protein][side 1] = ADP + phosphate + vitamin B12[side 2] + [cobalamin-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
vitamin B12-[cobalamin-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
vitamin B12[side 2];
[cobalamin-binding protein][side 1]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of cobalamin derivatives.
History
EC 7.6.2.8 created 2000 as EC 3.6.3.33, transferred 2018 to EC 7.6.2.8
Orthology
K06074  vitamin B12 transport system ATP-binding protein
Genes
ECO: b1709(btuD)
ECJ: JW1699(btuD)
ECD: ECDH10B_1845(btuD)
EBW: BWG_1523(btuD)
ECOK: ECMDS42_1382(btuD)
ECE: Z2738(btuD)
ECS: ECs2416
ECF: ECH74115_2427(btuD)
ETW: ECSP_2276(btuD)
ELX: CDCO157_2250
EOJ: ECO26_2438(btuD)
EOI: ECO111_2179(btuD)
EOH: ECO103_1853(btuD)
ECOO: ECRM13514_2206(btuD)
ECOH: ECRM13516_2111(btuD)
ECG: E2348C_1794(btuD)
EOK: G2583_2106(btuD)
ESO: O3O_13950
ESM: O3M_11650
ESL: O3K_11685
ECW: EcE24377A_1928(btuD)
ELH: ETEC_1742
ECC: c2105(btuD)
ECP: ECP_1657
ECI: UTI89_C1902(btuD)
ECV: APECO1_784(btuC)
ECX: EcHS_A1789(btuD)
ECM: EcSMS35_1481(btuD)
ECY: ECSE_1834
ECR: ECIAI1_1765(btuD)
ECQ: ECED1_1911(btuD)
ECK: EC55989_1877(btuD)
ECT: ECIAI39_1344(btuD)
EOC: CE10_1989(btuD)
EUM: ECUMN_2000(btuD)
ECZ: ECS88_1760(btuD)
ELO: EC042_1876(btuD)
ESE: ECSF_1570
EBR: ECB_01678(btuD)
EBD: ECBD_1936
EKF: KO11_14200(btuD)
EAB: ECABU_c19640(btuD)
EDJ: ECDH1ME8569_1653(btuD)
EIH: ECOK1_1829(btuD)
ENA: ECNA114_1757(btuD)
ELW: ECW_m1878(btuD)
ELL: WFL_09200(btuD)
ELC: i14_1927(btuD)
ELD: i02_1927(btuD)
ELP: P12B_c1374(btuD)
EBL: ECD_01678(btuD)
EBE: B21_01667(btuD)
ELF: LF82_0250(btuD)
ECOI: ECOPMV1_01808(btuD)
ECOJ: P423_09115
ECOS: EC958_1931(btuD)
EFE: EFER_1355(btuD)
EAL: EAKF1_ch4343(btuD)
STY: STY1768(btuD)
STT: t1223(btuD)
STM: STM1342(btuD)
SEO: STM14_1629(btuD)
SEY: SL1344_1276(btuD)
SEJ: STMUK_1309(btuD)
SEB: STM474_1346(btuD)
SEF: UMN798_1398(btuD)
SENR: STMDT2_12751(btuD)
SEND: DT104_13191(btuD)
SENI: CY43_06830
SPT: SPA1501(btuD)
SEK: SSPA1393
SEI: SPC_2389(btuD)
SEC: SCH_1361(btuD)
SHB: SU5_01960
SENS: Q786_08545
SED: SeD_A2003
SEG: SG1775(btuD)
SEL: SPUL_1158(btuD)
SEGA: SPUCDC_1158(btuD)
SET: SEN1702(btuD)
SENA: AU38_08815
SENO: AU37_08820
SENV: AU39_08825
SENQ: AU40_09840
SENL: IY59_09010
SEEP: I137_05330
SENB: BN855_13770(btuD)
SENE: IA1_06615
SBG: SBG_1194(btuD)
SBZ: A464_1387
SFL: SF1522(btuD)
SFX: S1639(btuD)
SFV: SFV_1514(btuD)
SFE: SFxv_1705(btuD)
SFN: SFy_2178
SFS: SFyv_2231
SFT: NCTC1_01641(btuD)
SSN: SSON_1449(btuD)
SBO: SBO_1419(btuD)
SBC: SbBS512_E1913(btuD)
SDY: SDY_1804(btuD)
ENC: ECL_02410
ECLO: ENC_14080
ECLX: LI66_09185
ECLY: LI62_09960
ECLZ: LI64_09250
EEC: EcWSU1_01819(btuD)
EBG: FAI37_20135(btuD)
ESA: ESA_02111
CSK: ES15_2266(btuD)
CTU: CTU_18540(btuD)
KPN: KPN_02166(btuD)
KPU: KP1_3269(btuD)
KPP: A79E_2073
KPT: VK055_0290(btuD)
KPE: KPK_2152(btuD)
KPR: KPR_2714(btuD)
KPJ: N559_2116
KPX: PMK1_04533(btuD)
KPNU: LI86_10515
KPNK: BN49_3274(btuD)
KVA: Kvar_2025
KOX: KOX_22880
KOE: A225_3456
EAE: EAE_17045
EAR: CCG30484
KLW: DA718_11910(btuD)
CKO: CKO_01735
CRO: ROD_13461(btuD)
CAMA: F384_06095
EBT: EBL_c15980(btuD)
RTG: NCTC13098_03070(btuD)
CLAP: NCTC11466_02639(btuD)
KOT: EH164_12780(btuD)
KIE: NCTC12125_01139(btuD)
LNI: CWR52_02990(btuD)
BUF: D8682_25480(btuD)
METY: MRY16398_23120(btuD)
AHN: NCTC12129_02302(btuD)
IZH: FEM41_16195(btuD)
EBF: D782_1948
PSTS: E05_12420
YPE: YPO2423(btuD)
YPK: y1916(btuD)
YPH: YPC_2058(btuD)
YPA: YPA_1767
YPN: YPN_1877
YPM: YP_2210(btuD)
YPZ: YPZ3_1464
YPD: YPD4_1429
YPX: YPD8_1516
YPW: CH59_4257
YPJ: CH55_499
YPV: BZ15_1102
YPL: CH46_2682
YPS: YPTB2331(btuD)
YPO: BZ17_123
YPI: YpsIP31758_1722(btuD)
YPY: YPK_1830
YPB: YPTS_2406
YPQ: DJ40_4254
YPU: BZ21_1619
YPR: BZ20_3912
YPC: BZ23_1905
YPF: BZ19_1696
YEN: YE2193(btuD)
YEY: Y11_07971
YEW: CH47_1628(btuD)
YET: CH48_3628
YEE: YE5303_20351(btuD)
YAL: AT01_259
YFR: AW19_1399
YIN: CH53_4136
YKR: CH54_263
YRO: CH64_738
YRU: BD65_482
YHI: D5F51_07855(btuD)
SPE: Spro_2153
SRL: SOD_c19670(btuD)
SPLY: Q5A_010885(btuD)
SMAF: D781_1984
SMW: SMWW4_v1c21820(btuD)
SMAR: SM39_1614(btuD)
SMAC: SMDB11_1427(btuD)
SERF: L085_17855
SQU: E4343_05445(btuD)
RAA: Q7S_14245
ECA: ECA1834(btuD)
PATR: EV46_08780
PATO: GZ59_27690
PCT: PC1_2467
PEC: W5S_2754
SOD: Sant_2070(btuD)
DDD: Dda3937_03648(btuD)
DDQ: DDI_2468
DAQ: DAQ1742_02803(btuD)
BRB: EH207_07340(btuD)
BNG: EH206_08550(btuD)
EBI: EbC_18900(btuD)
EGE: EM595_1671(btuD)
PAM: PANA_1704(btuD)
PLF: PANA5342_2511(btuD)
PAJ: PAJ_1052(btuD)
PVA: Pvag_1144(btuD)
PSTW: DSJ_12905
PANS: FCN45_08610(btuD)
PLU: plu2661(btuD)
PAY: PAU_01874(btuD)
PMR: PMI1042(btuD)
PMIB: BB2000_1079(btuD)
PHAU: PH4a_14240
XBO: XBJ1_2537(btuD)
XBV: XBW1_3013(btuD)
XNE: XNC1_1834(btuD)
XNM: XNC2_1779(btuD)
XPO: XPG1_1545(btuD)
PSI: S70_19350
PSX: DR96_2782
PRG: RB151_019220(btuD)
PHEI: NCTC12003_02335(btuD)
PRJ: NCTC6933_01640(btuD)
MMK: MU9_2439
ETR: ETAE_1806(btuD)
ETD: ETAF_1633(btuD)
ETE: ETEE_3850(btuD)
LRI: NCTC12151_01698(btuD)
PSHI: SAMEA2665130_1515(btuD)
VCH: VC1245
VCS: MS6_1027
VCI: O3Y_05790
VVU: VV1_2781
VVY: VV1481
VPA: VP1312
VPB: VPBB_1236
VAG: N646_0350
VSP: VS_1695
VAN: VAA_03078
VAU: VANGNB10_cI1522c(btuD)
VSC: VSVS12_01612(btuD)
VTA: A0506(btuD)
VAF: D1115_08020(btuD)
PPR: PBPRA2151(SF1522)
SALY: E8E00_06860(btuD)
SKS: FCN78_06525(btuD)
PSEO: OM33_15130
PSPO: PSPO_b1823(btuD)
PTU: PTUN_b0956(btuD)
AMAL: I607_06450
AMAE: I876_06740
AMAO: I634_06860
AMAD: I636_07280
AMAI: I635_07190
AMAG: I533_06795
AMAC: MASE_06310
GNI: GNIT_1361
MVS: MVIS_3061(btuD)
AHA: AHA_2735
ASA: ASA_1638(btuD)
AVR: B565_1402
AMED: B224_3022
ASR: WL1483_12(btuD)
TAU: Tola_1733
OCE: GU3_08245
 » show all
Taxonomy
Reference
1  [PMID:3528129]
  Authors
Friedrich MJ, de Veaux LC, Kadner RJ.
  Title
Nucleotide sequence of the btuCED genes involved in vitamin B12 transport in Escherichia coli and homology with components of periplasmic-binding-protein-dependent transport systems.
  Journal
J Bacteriol 167:928-34 (1986)
DOI:10.1128/JB.167.3.928-934.1986
  Sequence
[eco:b1711 b1709]
Reference
2  [PMID:7569321]
  Authors
Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr.
  Title
Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases.
  Journal
Res Microbiol 146:271-8 (1995)
DOI:10.1016/0923-2508(96)81050-3
Reference
3  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv Microb Physiol 40:81-136 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 7.6.2.8
IUBMB Enzyme Nomenclature: 7.6.2.8
ExPASy - ENZYME nomenclature database: 7.6.2.8
BRENDA, the Enzyme Database: 7.6.2.8

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