KEGG   Equus caballus (horse): 100051485
Entry
100051485         CDS       T01058                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ecb  Equus caballus (horse)
Pathway
ecb00562  Inositol phosphate metabolism
ecb01100  Metabolic pathways
ecb04015  Rap1 signaling pathway
ecb04020  Calcium signaling pathway
ecb04022  cGMP-PKG signaling pathway
ecb04062  Chemokine signaling pathway
ecb04070  Phosphatidylinositol signaling system
ecb04071  Sphingolipid signaling pathway
ecb04072  Phospholipase D signaling pathway
ecb04261  Adrenergic signaling in cardiomyocytes
ecb04270  Vascular smooth muscle contraction
ecb04310  Wnt signaling pathway
ecb04371  Apelin signaling pathway
ecb04540  Gap junction
ecb04611  Platelet activation
ecb04613  Neutrophil extracellular trap formation
ecb04621  NOD-like receptor signaling pathway
ecb04713  Circadian entrainment
ecb04720  Long-term potentiation
ecb04723  Retrograde endocannabinoid signaling
ecb04724  Glutamatergic synapse
ecb04725  Cholinergic synapse
ecb04726  Serotonergic synapse
ecb04728  Dopaminergic synapse
ecb04730  Long-term depression
ecb04742  Taste transduction
ecb04750  Inflammatory mediator regulation of TRP channels
ecb04911  Insulin secretion
ecb04912  GnRH signaling pathway
ecb04915  Estrogen signaling pathway
ecb04916  Melanogenesis
ecb04918  Thyroid hormone synthesis
ecb04919  Thyroid hormone signaling pathway
ecb04921  Oxytocin signaling pathway
ecb04922  Glucagon signaling pathway
ecb04924  Renin secretion
ecb04925  Aldosterone synthesis and secretion
ecb04926  Relaxin signaling pathway
ecb04927  Cortisol synthesis and secretion
ecb04928  Parathyroid hormone synthesis, secretion and action
ecb04929  GnRH secretion
ecb04933  AGE-RAGE signaling pathway in diabetic complications
ecb04934  Cushing syndrome
ecb04935  Growth hormone synthesis, secretion and action
ecb04961  Endocrine and other factor-regulated calcium reabsorption
ecb04970  Salivary secretion
ecb04971  Gastric acid secretion
ecb04972  Pancreatic secretion
ecb04973  Carbohydrate digestion and absorption
ecb05010  Alzheimer disease
ecb05016  Huntington disease
ecb05017  Spinocerebellar ataxia
ecb05022  Pathways of neurodegeneration - multiple diseases
ecb05142  Chagas disease
ecb05143  African trypanosomiasis
ecb05146  Amoebiasis
ecb05163  Human cytomegalovirus infection
ecb05200  Pathways in cancer
ecb05415  Diabetic cardiomyopathy
ecb05417  Lipid and atherosclerosis
Module
ecb_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ecb00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100051485 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100051485 (PLCB4)
   04310 Wnt signaling pathway
    100051485 (PLCB4)
   04371 Apelin signaling pathway
    100051485 (PLCB4)
   04020 Calcium signaling pathway
    100051485 (PLCB4)
   04070 Phosphatidylinositol signaling system
    100051485 (PLCB4)
   04072 Phospholipase D signaling pathway
    100051485 (PLCB4)
   04071 Sphingolipid signaling pathway
    100051485 (PLCB4)
   04022 cGMP-PKG signaling pathway
    100051485 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100051485 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100051485 (PLCB4)
   04613 Neutrophil extracellular trap formation
    100051485 (PLCB4)
   04621 NOD-like receptor signaling pathway
    100051485 (PLCB4)
   04062 Chemokine signaling pathway
    100051485 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    100051485 (PLCB4)
   04922 Glucagon signaling pathway
    100051485 (PLCB4)
   04929 GnRH secretion
    100051485 (PLCB4)
   04912 GnRH signaling pathway
    100051485 (PLCB4)
   04915 Estrogen signaling pathway
    100051485 (PLCB4)
   04921 Oxytocin signaling pathway
    100051485 (PLCB4)
   04926 Relaxin signaling pathway
    100051485 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    100051485 (PLCB4)
   04918 Thyroid hormone synthesis
    100051485 (PLCB4)
   04919 Thyroid hormone signaling pathway
    100051485 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    100051485 (PLCB4)
   04916 Melanogenesis
    100051485 (PLCB4)
   04924 Renin secretion
    100051485 (PLCB4)
   04925 Aldosterone synthesis and secretion
    100051485 (PLCB4)
   04927 Cortisol synthesis and secretion
    100051485 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100051485 (PLCB4)
   04270 Vascular smooth muscle contraction
    100051485 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    100051485 (PLCB4)
   04971 Gastric acid secretion
    100051485 (PLCB4)
   04972 Pancreatic secretion
    100051485 (PLCB4)
   04973 Carbohydrate digestion and absorption
    100051485 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100051485 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    100051485 (PLCB4)
   04725 Cholinergic synapse
    100051485 (PLCB4)
   04728 Dopaminergic synapse
    100051485 (PLCB4)
   04726 Serotonergic synapse
    100051485 (PLCB4)
   04720 Long-term potentiation
    100051485 (PLCB4)
   04730 Long-term depression
    100051485 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    100051485 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    100051485 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    100051485 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100051485 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100051485 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    100051485 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100051485 (PLCB4)
   05142 Chagas disease
    100051485 (PLCB4)
   05143 African trypanosomiasis
    100051485 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100051485 (PLCB4)
   05016 Huntington disease
    100051485 (PLCB4)
   05017 Spinocerebellar ataxia
    100051485 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    100051485 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100051485 (PLCB4)
   05415 Diabetic cardiomyopathy
    100051485 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100051485 (PLCB4)
   04934 Cushing syndrome
    100051485 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ecb04131]
    100051485 (PLCB4)
Enzymes [BR:ecb01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100051485 (PLCB4)
Membrane trafficking [BR:ecb04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100051485 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100051485 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y DUF1154 EF-hand_like C2 EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 100051485
NCBI-ProteinID: XP_023481894
Ensembl: ENSECAG00000012335
VGNC: 21538
Position
22:complement(14529082..14918455)
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGASPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKTKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNEKKGKANTAKANVTPQ
SSSELRPTTTAALGPGMEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSM
KLQNAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagtgccttcctttttgcaagaagga
gcagtttttgacagatatgaagaggaatcttttgtgtttgaacccaactgcctcttcaaa
gtggatgagtttggcttctttctgacctggagaagtgaaggcaaggaaggacaagtgcta
gaatgttccctcatcaacagtgttcggttgggagcctcaccaaaggatcccaaaatcctg
gctgctcttgaagctgttggaaaatcagaaaatgatctggaagggcggatagtttgtgtc
tgcagtggtacagatctggtgaacatcagtttcacgtacatggtggctgaaaatccagaa
gtaacaaagcaatgggtcgaaggcctgagatcaatcatacacaacttcagggccaacaac
gtcagtccaatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcctcggggaaaacagaaaag
gtgatctttcaagcgctcaaggaattaggtcttcccagtggaaagaatgatgaaatcgag
cctgcggcatttacttatgaaaagttctatgaactgacgcaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgagattttattt
ccattttatgatgctaaaagggcaatgcagatcattgagatgtatgagcccgatgaagat
ttgaagacaaaaggcctcatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aatgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacctatctcaccggccggcagtttggcgggaag
tcttcagtagaaatgtacagacaggtcctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaagaccaagaaccgataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcgtttgtcacatcc
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggacctcctgttgaaacaagcacttgaatcgcat
ccactcgaaccaggcaggcccttgccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaagttgaaaaaaaacagctcgaagctttgaaaagcatg
atggaagctggagaatctgctgccccagttagcatcttagaggatgataatgaagaggaa
atagaaagtgctgaccaagaggaggaagctcaccctgaatacaaatttggaaatgaactt
tctgctgatgacctgggtcacaaggaagctgttgcaaatagtgtcaagaaggcttcagat
gaccttgaacatgaaaacaacaaaaagggcctggttactgtagaagatgagcaggcgtgg
atggcgtcctataaatacgtgggtgctaccactaacatccatccctatctgtccacaatg
atcaactatgcacagcccgtgaaatttcaaggtttccatgtcgctgaagaacgcaatatt
cattataacatgtcttcttttaatgagtcagtcggtctaggctacctgaagacacatgcg
attgaatttgtgaattataacaaacgacaaatgagtcgtatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttca
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcctgcgggtaccttctcaaaccagatttcatgagacgacccgatcgaacatttgat
cccttctctgaaactcctgtcgatggggtcattgcagccacttgctcagtgcaggtcata
tcaggtcagttcttgtcagacaagaaaattggcacatatgtagaagttgacatgtatggg
ttgcccacggacactatacgtaaggagttccgaactcgcatggtgatgaacaatggactc
aatccagtttacaatgaagaatcatttgtatttcggaaggtaatcctccctgacctggca
gtcttgagaatagcagtgtatgatgacaacaacaggctgattggccagaggattcttcca
ctggatggcctccaagcaggttatcggcacatatcccttcgaaatgagggaaataaacca
ctatcactgccaacgattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtagatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagctgatgtgcccagtgac
acttctaagaatgagaagaaaggaaaggccaacactgccaaagcaaatgtgaccccacag
agcagctccgagctcagaccaaccaccacagccgccctggggcctggcatggaagccaag
aaaggtattgaacttatccctcaagtaaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagctaaattctttaaagaagaaacatgcaaag
gaacacagtaccatgcaaaagctacactgcacgcaagttgacaaaatcgtggcacagtat
gacaaagagaagtcgactcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtcttgaaatgaaaaaagaaacagaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagattgtggcccagcacacaaaggagtggtcagaaatgatc
aacacccacagtgctgaggagcaagaaatccgggacctgcacctcagccagcagtgcgag
ctgctgagaaagctcctgatcagtgcccacgagcagcaaacccagcagctaaaactgtcc
catgacagggaaagcaaagaaatgagagcacaccaggctaagatttctatggaaaatagc
aaggccatcagccaagataaatctatcaagaataaagcagaacgggaaaggcgagtcagg
gagttaaacagcagcaatactaaaaagtttctggaagaaagaaagagacttgcaatgaaa
cagtccaaagaaatggatcagctgaaaaaagtccagcttgaacacctagaattcctagag
aaacagaatgagcagcttttgaaatcctgtcatgcagtgtcccaaacgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatg
aaactccaaaacgcaaactga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (61)   
   KEGG PATHWAY (60)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (4)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (8)   
   Pfam (8)   
All databases (109)   

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