KEGG   Equus caballus (horse): 100055407Help
Entry
100055407         CDS       T01058                                 

Gene name
PLCB3
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ecb  Equus caballus (horse)
Pathway
ecb00562  Inositol phosphate metabolism
ecb01100  Metabolic pathways
ecb04015  Rap1 signaling pathway
ecb04020  Calcium signaling pathway
ecb04022  cGMP-PKG signaling pathway
ecb04062  Chemokine signaling pathway
ecb04070  Phosphatidylinositol signaling system
ecb04071  Sphingolipid signaling pathway
ecb04072  Phospholipase D signaling pathway
ecb04261  Adrenergic signaling in cardiomyocytes
ecb04270  Vascular smooth muscle contraction
ecb04310  Wnt signaling pathway
ecb04371  Apelin signaling pathway
ecb04540  Gap junction
ecb04611  Platelet activation
ecb04621  NOD-like receptor signaling pathway
ecb04713  Circadian entrainment
ecb04720  Long-term potentiation
ecb04723  Retrograde endocannabinoid signaling
ecb04724  Glutamatergic synapse
ecb04725  Cholinergic synapse
ecb04726  Serotonergic synapse
ecb04728  Dopaminergic synapse
ecb04730  Long-term depression
ecb04750  Inflammatory mediator regulation of TRP channels
ecb04911  Insulin secretion
ecb04912  GnRH signaling pathway
ecb04915  Estrogen signaling pathway
ecb04916  Melanogenesis
ecb04918  Thyroid hormone synthesis
ecb04919  Thyroid hormone signaling pathway
ecb04921  Oxytocin signaling pathway
ecb04922  Glucagon signaling pathway
ecb04924  Renin secretion
ecb04925  Aldosterone synthesis and secretion
ecb04926  Relaxin signaling pathway
ecb04927  Cortisol synthesis and secretion
ecb04928  Parathyroid hormone synthesis, secretion and action
ecb04933  AGE-RAGE signaling pathway in diabetic complications
ecb04934  Cushing's syndrome
ecb04961  Endocrine and other factor-regulated calcium reabsorption
ecb04970  Salivary secretion
ecb04971  Gastric acid secretion
ecb04972  Pancreatic secretion
ecb05010  Alzheimer's disease
ecb05016  Huntington's disease
ecb05142  Chagas disease (American trypanosomiasis)
ecb05143  African trypanosomiasis
ecb05146  Amoebiasis
ecb05163  Human cytomegalovirus infection
ecb05200  Pathways in cancer
Module
ecb_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ecb00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100055407 (PLCB3)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100055407 (PLCB3)
   04310 Wnt signaling pathway
    100055407 (PLCB3)
   04371 Apelin signaling pathway
    100055407 (PLCB3)
   04020 Calcium signaling pathway
    100055407 (PLCB3)
   04070 Phosphatidylinositol signaling system
    100055407 (PLCB3)
   04072 Phospholipase D signaling pathway
    100055407 (PLCB3)
   04071 Sphingolipid signaling pathway
    100055407 (PLCB3)
   04022 cGMP - PKG signaling pathway
    100055407 (PLCB3)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    100055407 (PLCB3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100055407 (PLCB3)
   04621 NOD-like receptor signaling pathway
    100055407 (PLCB3)
   04062 Chemokine signaling pathway
    100055407 (PLCB3)
  Endocrine system
   04911 Insulin secretion
    100055407 (PLCB3)
   04922 Glucagon signaling pathway
    100055407 (PLCB3)
   04912 GnRH signaling pathway
    100055407 (PLCB3)
   04915 Estrogen signaling pathway
    100055407 (PLCB3)
   04921 Oxytocin signaling pathway
    100055407 (PLCB3)
   04926 Relaxin signaling pathway
    100055407 (PLCB3)
   04918 Thyroid hormone synthesis
    100055407 (PLCB3)
   04919 Thyroid hormone signaling pathway
    100055407 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    100055407 (PLCB3)
   04916 Melanogenesis
    100055407 (PLCB3)
   04924 Renin secretion
    100055407 (PLCB3)
   04925 Aldosterone synthesis and secretion
    100055407 (PLCB3)
   04927 Cortisol synthesis and secretion
    100055407 (PLCB3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100055407 (PLCB3)
   04270 Vascular smooth muscle contraction
    100055407 (PLCB3)
  Digestive system
   04970 Salivary secretion
    100055407 (PLCB3)
   04971 Gastric acid secretion
    100055407 (PLCB3)
   04972 Pancreatic secretion
    100055407 (PLCB3)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100055407 (PLCB3)
  Nervous system
   04724 Glutamatergic synapse
    100055407 (PLCB3)
   04725 Cholinergic synapse
    100055407 (PLCB3)
   04728 Dopaminergic synapse
    100055407 (PLCB3)
   04726 Serotonergic synapse
    100055407 (PLCB3)
   04720 Long-term potentiation
    100055407 (PLCB3)
   04730 Long-term depression
    100055407 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    100055407 (PLCB3)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100055407 (PLCB3)
  Environmental adaptation
   04713 Circadian entrainment
    100055407 (PLCB3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100055407 (PLCB3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100055407 (PLCB3)
   05016 Huntington's disease
    100055407 (PLCB3)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100055407 (PLCB3)
   04934 Cushing's syndrome
    100055407 (PLCB3)
  Infectious diseases
   05163 Human cytomegalovirus infection
    100055407 (PLCB3)
   05146 Amoebiasis
    100055407 (PLCB3)
   05142 Chagas disease (American trypanosomiasis)
    100055407 (PLCB3)
   05143 African trypanosomiasis
    100055407 (PLCB3)
Enzymes [BR:ecb01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100055407 (PLCB3)
Membrane trafficking [BR:ecb04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100055407 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100055407 (PLCB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI-PLC-X PLC-beta_C PI-PLC-Y EF-hand_like C2 DUF1154 BPL_N
Motif
Other DBs
NCBI-GeneID: 100055407
NCBI-ProteinID: XP_023510066
Ensembl: ENSECAG00000011700
VGNC: 21537
Position
12
AA seq 1230 aa AA seqDB search
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDANGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRHSQARQLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHQPSTGVPGS
SVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVALEKPSLEPQKSLGE
EGPQRGPDALGPVDREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQAGPETCQETQSQQL
GSQLTPNPTPSTLDTSPRRPPGTVTSPTSPSLSSPGQRDDLVASILAEVAPAPLDELRGH
KALVKLRSRQERDLRELRKKHQRKAVALTRRLLDGLAQARAEGRCRPRPGGLGGEDEKEE
EKEVKHYQEFQKRQVQSLLELREAQADTESKWRLEHLRQAQQRLREVVLDAHTTQLKRLK
ETNDREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQK
QRQERLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEVRRSLLGETPEGLGDGHL
VACASNGHAPGSSGHLSGADSESQEENTKL
NT seq 3693 nt NT seq  +upstreamnt  +downstreamnt
atggcaggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtgaccctgcgcgtggacgccaatggcttctttttgtactggacaggacccaacatggaa
gtggacacactggacatcagttccatcagggacacgcggacaggccgttacgcccgcctg
cccaaggaccccaagatccgggaggtgctgggctttgggggccccgatgcccggctggag
gagaagctgatgacggtggtggccgggccagacccggtgaacacgacattcttgaacttc
atggccgtgcaggacgacacagccaaggtctggtccgaggagctgttcaagctggctatg
aacatcctggctcagaatgcctcccggaacaccttcttgcgcaaagcatacacgaagctg
aagctgcaggtgaaccaggatgggaggatcccggtgaagaacatcctgaagatgttctca
gcagacaagaagcgggtggaaactgcgctggaatcctgtggcctcaatttcaatcggagc
gagtccatccggcccgacgagttttccttggaaatcttcgagcggttcctgaacaagctg
tgtctgcggccggacattgacaagatcctgctggagataggcgccaagggcaagccatac
ctgacgctagagcagctcatggacttcatcaaccagaagcagcgggacccgaggctcaac
gaggtgctgtacccgcccctgcggcactcccaggcgaggcagctcatcgagaagtacgaa
cccaaccagcagttcctggagcgagaccagatgtccatggaaggtttcagccgctacctg
ggaggtgaggagaacggcatcctgcccctggaggccctggacctgagcgccgacatgacg
cagccgctcagtgcttacttcatcaactcttcccataacacctacctcacggcggggcag
ctggccgggacctcgtcggtggagatgtaccggcaggcgctgctgtggggctgccgctgc
gtggagctggacgtgtggaaggggcggccgcccgaggaggagccattcatcacgcacggc
ttcaccatgaccaccgaggtgccgctgcgggacgtgctcgaggccatcgcggagaccgcc
ttcaagacctcgccctaccccgtcatcctctccttcgagaaccacgtggactcggcaaag
cagcaggccaagatggccgagtactgccgctccatctttggggacgcgctgctcatcgac
ccactggacaagtacccgctggccccaggcgtccccctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaataagaagcggcaccagcccagcacgggcgtccccggcagc
tccgtgcgcaagaggccgctggagcagagcaactcggccctgagcgagagctctgccgcc
accgagccttcctcgccccagctcgggtcccccagctccgacagctgccccggcctgagc
aacggggaggaggtggccctcgagaagcccagcctggagcctcagaagtctctgggggag
gaggggccgcagcggggccccgatgctcttggacctgttgaccgcgaggatgaggaggaa
gacgaggaagaggaggaacagacggaccccaaaaagcccaccacggatgagggcaccgcc
agcagcgaggtcaatgccacagaggaaatgtcgaccctcgtcaactacatcgagcccgtc
aagttcaagtccttcgaggctgcccgaaagaggaacaagtgcttcgagatgtcgtccttc
gtggagaccaaggccatggagcagctgaccaagagccccatggagttcgtggaatacaac
aagcagcagctgagccgtatctaccccaagggcacccgcgtggactcgtctaactacatg
ccccagctcttctggaatgtgggctgccagcttgtcgcgctcaacttccagaccctggat
gtggcgatgcagctcaacgcgggcgtgttcgagtacaacgggcgcagcggctacctgctt
aaacccgagttcatgcggcggccggacaagtcctttgaccccttcaccgaggtcatcgtg
gatggcatcgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctgtccgac
aggaaggtgggcatctacgtggaggtggatatgttcggcctccctgtggacacgcggcgc
aagtaccgcacgcggacctctcaggggaactcgttcaaccccgtgtgggatgaggagccc
ttcgacttccccaaggtggtgctgcccacgctggcttcactgcgcatcgcggcttttgag
gagggcggcaagttcgtggggcaccggatcctgcccgtctctgccatccgctcagggtac
cactacatctgcctgcggaacgaggccaaccagccgctgtgcctgccggccctgctcatc
tacaccgaggcctccgactacatccctgacgaccaccaggactacgcagaggccctgatc
aaccccatcaagcatgtcagcctgatggaccagagggccaagcagctggctgccctcatt
ggggagagcgaggctcaggctggcccggagacatgccaggagacccagtctcagcagctg
gggtcccagctgaccccaaaccccacacccagcacactggacacctccccccgccggccc
ccaggcactgtcacctcccccaccagtccgtccctcagcagcccaggccaacgggatgat
ctcgtcgccagcatcctcgcagaggtggccccagccccactggacgagctccgaggccac
aaggctctggtgaagctccggagccggcaggagcgagacctgcgggagctgcgcaagaag
catcagcggaaggccgtagccctcactcgccgcctgctcgacggcctggcccaggctcgg
gccgagggcaggtgccggccccggccaggtggcctaggcggggaggacgagaaggaggag
gagaaagaggtgaagcactatcaggagttccagaaaagacaggtgcagagtctgctggag
ctgagggaggcccaggccgacacagagagcaagtggaggctggagcacctgcgacaggct
cagcagcggctcagggaggttgtcctggatgcacacacaacccagttaaagaggctgaag
gagacgaacgacagggagaagaaggaactgcagaagatcctggacaggaagcgccacaac
agtatctcggaggccaagacaagggagaaacataagaaggaggcggaactgaccgagatc
aaccgtcggcacatcactgagtcggtcaactccatccgtcggctggaggaggcccagaag
cagcggcaggagcgccttgtggccgggcagcagcaggtcctgcagcagctggcagaagag
gagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgggcaaggctgccc
caggaggtccgccggagcctgctgggcgagacgccggaggggctgggggacgggcatctg
gtggcctgtgccagcaacggtcacgcgcccgggagcagcgggcacctgtctggtgctgac
tcggagagccaagaggagaatacgaagctctga

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