KEGG   Equus caballus (horse): 100062388
Entry
100062388         CDS       T01058                                 
Symbol
PTEN
Name
(RefSeq) phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
ecb  Equus caballus (horse)
Pathway
ecb00562  Inositol phosphate metabolism
ecb01100  Metabolic pathways
ecb01521  EGFR tyrosine kinase inhibitor resistance
ecb04068  FoxO signaling pathway
ecb04070  Phosphatidylinositol signaling system
ecb04071  Sphingolipid signaling pathway
ecb04115  p53 signaling pathway
ecb04140  Autophagy - animal
ecb04150  mTOR signaling pathway
ecb04151  PI3K-Akt signaling pathway
ecb04218  Cellular senescence
ecb04510  Focal adhesion
ecb04931  Insulin resistance
ecb05165  Human papillomavirus infection
ecb05166  Human T-cell leukemia virus 1 infection
ecb05200  Pathways in cancer
ecb05206  MicroRNAs in cancer
ecb05208  Chemical carcinogenesis - reactive oxygen species
ecb05213  Endometrial cancer
ecb05214  Glioma
ecb05215  Prostate cancer
ecb05218  Melanoma
ecb05222  Small cell lung cancer
ecb05224  Breast cancer
ecb05225  Hepatocellular carcinoma
ecb05230  Central carbon metabolism in cancer
ecb05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ecb05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ecb00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100062388 (PTEN)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    100062388 (PTEN)
   04070 Phosphatidylinositol signaling system
    100062388 (PTEN)
   04071 Sphingolipid signaling pathway
    100062388 (PTEN)
   04151 PI3K-Akt signaling pathway
    100062388 (PTEN)
   04150 mTOR signaling pathway
    100062388 (PTEN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100062388 (PTEN)
  09143 Cell growth and death
   04115 p53 signaling pathway
    100062388 (PTEN)
   04218 Cellular senescence
    100062388 (PTEN)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100062388 (PTEN)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100062388 (PTEN)
   05206 MicroRNAs in cancer
    100062388 (PTEN)
   05208 Chemical carcinogenesis - reactive oxygen species
    100062388 (PTEN)
   05230 Central carbon metabolism in cancer
    100062388 (PTEN)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100062388 (PTEN)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    100062388 (PTEN)
   05214 Glioma
    100062388 (PTEN)
   05218 Melanoma
    100062388 (PTEN)
   05215 Prostate cancer
    100062388 (PTEN)
   05213 Endometrial cancer
    100062388 (PTEN)
   05224 Breast cancer
    100062388 (PTEN)
   05222 Small cell lung cancer
    100062388 (PTEN)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100062388 (PTEN)
   05165 Human papillomavirus infection
    100062388 (PTEN)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    100062388 (PTEN)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    100062388 (PTEN)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100062388 (PTEN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:ecb01009]
    100062388 (PTEN)
Enzymes [BR:ecb01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     100062388 (PTEN)
    3.1.3.48  protein-tyrosine-phosphatase
     100062388 (PTEN)
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     100062388 (PTEN)
Protein phosphatases and associated proteins [BR:ecb01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    100062388 (PTEN)
SSDB
Motif
Pfam: PTEN_C2 DSPc Y_phosphatase PTPlike_phytase Y_phosphatase3 DUF3256
Other DBs
NCBI-GeneID: 100062388
NCBI-ProteinID: NP_001304189
Ensembl: ENSECAG00000017012
VGNC: 21984
UniProt: A0A024QYT2
Position
1:complement(40850970..40941794)
AA seq 576 aa
MERGGEASAAAAAAAAAPGRGSESPVTISRAGNAGELVSPLLLPPTRRRRRRHIQGPGPV
LNLPSAAAAPPLARAPEAAGGGSRSEDYSSSPHSAAAAARPLAAEEKQAQSLQPSSSRRS
SHYPAAVQSQAAAERGASATAKSRAISILQKKPRHQQLLPSLSSFFFSHRLPDMTAIIKE
IVSRNKRRYQEDGFDLDLTYIYPTLLLWGFLQKRLEGVYXNNIDDVVRFLDSKHKNHYKI
YNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAG
KGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLD
YRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPL
PVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIE
RADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTP
DVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
NT seq 1731 nt   +upstreamnt  +downstreamnt
ctggagcgggggggagaagcgtcggcggcggcggccgcggcggctgcagctccggggagg
gggtcggagtcgcctgtcaccatttccagggctgggaacgccggagagttggtctctccc
cttctactgcctccaacacggcggcggcggcggcggcacatccagggacccgggccggtt
ttaaacctcccctccgccgccgccgcaccccccctggcccgggctccggaggccgccgga
ggaggcagccgttccgaggattattcgtcttctccccattccgctgccgccgctgccagg
cctctggctgctgaggagaagcaggcccagtcgctgcaaccatccagcagccgccgcagc
agccattacccggctgcggtccagagccaagcggcagcagagcgaggggcatcagctacc
gccaagtccagagccatttccatcctgcagaagaagccccgccaccagcagcttctgcca
tctctctcctcctttttcttcagccacaggctcccagacatgacagccatcattaaagag
atcgttagcagaaacaaaaggagatatcaagaggatggattcgacttagacttgacctat
atttatccaacattattgctatggggtttcctgcagaaaagacttgaaggcgtatacnag
aacaatatcgatgatgtagtaaggtttttggattcaaagcataaaaaccattacaagata
tacaatctatgtgctgaaagacattatgataccgccaaatttaactgcagagttgcacag
tatccttttgaagatcataatccaccacagctagaacttatcaaacccttttgtgaagat
cttgaccaatggctaagtgaagatgacaatcatgttgcagcaattcactgtaaagctgga
aagggacgaactggtgtaatgatttgtgcatatttgttacatcggggcaagtttttaaag
gcacaggaggccctagatttctatggagaagtaaggaccagagataaaaagggagtaact
attcccagtcagaggcgctatgtgtattattatagctacctgttaaagaatcatctggat
tatagaccagtggcactgttgtttcacaagatgatgtttgaaactattccaatgttcagt
ggcggaacttgcaatcctcagtttgtggtctgccagctaaaggtgaagatatattcctcc
aattcaggacccacacgacgggaagacaagttcatgtactttgagttccctcagccgttg
cctgtgtgtggtgacatcaaagtagagttcttccacaaacagaacaagatgctaaaaaag
gacaaaatgtttcacttttgggtaaatacattctttataccaggaccagaggaaacctca
gaaaaagtagaaaatggaagtctatgtgatcaagaaattgatagtatttgcagtatagag
cgtgcagataatgacaaagaatatctagtactcactttaacaaaaaatgatctcgacaaa
gcaaataaagacaaggccaaccgatacttttctccaaattttaaggtgaagctgtacttc
acaaaaacagtagaggagccatcaaatccagaggctagcagttcaacttctgtaacacca
gatgttagtgacaatgaacctgatcattatagatattctgacaccactgactctgatcca
gagaatgaaccttttgatgaagatcagcatacacaaattacaaaagtctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (28)   
   KEGG PATHWAY (28)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (5)   
   KEGG ENZYME (3)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
Protein domain (6)   
   Pfam (6)   
All databases (75)   

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