KEGG   Equus caballus (horse): 100065577
Entry
100065577         CDS       T01058                                 
Symbol
HMGCR
Name
(RefSeq) 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1
  KO
K00021  hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34]
Organism
ecb  Equus caballus (horse)
Pathway
ecb00900  Terpenoid backbone biosynthesis
ecb01100  Metabolic pathways
ecb04152  AMPK signaling pathway
ecb04976  Bile secretion
Module
ecb_M00095  C5 isoprenoid biosynthesis, mevalonate pathway
Brite
KEGG Orthology (KO) [BR:ecb00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    100065577 (HMGCR)
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    100065577 (HMGCR)
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    100065577 (HMGCR)
Enzymes [BR:ecb01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.34  hydroxymethylglutaryl-CoA reductase (NADPH)
     100065577 (HMGCR)
SSDB
Motif
Pfam: HMG-CoA_red Sterol-sensing Patched
Other DBs
NCBI-GeneID: 100065577
NCBI-ProteinID: XP_001504728
Ensembl: ENSECAG00000021330
VGNC: 18807
Position
14:complement(89846606..89867388)
AA seq 888 aa
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAVLGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAENSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEKAETESTLSLKNPITSPVVT
QKKVPDDCCRREPVLVTKSQKFHAAAEEMRINTERKVEVIKPLVAEADTSNRATFVVGSS
SSLIASPELETQEPEIELPLEPRPDEECLRILGDVEKGAKFLSDAEIIQLVNAKHIPAYK
LESLMETHERGVSIRRQLLSTKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRILADGMTRGPVVRLPRAC
DSAEVKAWLETPEGFTVIKEAFDSTSRFARLQKLHTSVAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLHEYFPDMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPARVVREV
LKTTTEAMVEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKENPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVRSHMIHNRSKVNLQGLQGTCTEKAA
NT seq 2667 nt   +upstreamnt  +downstreamnt
atgttgtcaagacttttccgaatgcatggcctctttgtggcctcccatccctgggaagtc
atagtggggacggtgacactgaccatctgtatgatgtccatgaacatgtttactggcaac
aataagatctgtggttggaattatgagtgtccaaagtttgaagaggatgttttgagcagt
gacattataattctgacaataacacgatgcatagcaatcctgtatatttatttccagttc
cagaatttacgtcagcttggatcaaaatatattttaggtattgctggcctcttcacaatt
ttctcaagttttgtattcagtacagttgtcattcatttcctagataaagaattgacaggc
ttgaacgaagctttgccctttttcctgcttctgattgacctttccagagcgagtgctctc
gcgaagtttgccctcagttccaactcgcaggatgaagtgagggagaatattgcccgtgga
atggcggttttaggtcccacgttcaccctcgacgctcttgtagaatgtcttgtgattgga
gttggtaccatgtcaggagtgcgtcaacttgaaattatgtgctgctttggctgcatgtct
gttctggccaactactttgtgttcatgactttcttcccggcttgtgtgtccttggtttta
gagctgtcccgggagagccgtgagggccgtccaatttggcagctcagccactttgctcga
gttttagaagaggaagaaaataaaccaaatcctgtgactcagagggtgaagatgattatg
tctctaggcttggttcttgttcatgctcacagtcgctggatagctgatccttctcctcaa
aacagtacagcagaaaattctaaggtttctttaggattggatgaaaacgtgtccaagaga
attgaaccaagtgtttccctctggcagttttatctctccaaaatgatcagcatggatatt
gaacaagttattaccctaagtttagctctccttctggctgtcaagtacatcttctttgaa
aaagcggagacagaatctacactctcattgaaaaaccctatcacatctccggtagtgacc
caaaagaaagtcccagacgactgttgtagacgtgaacctgtactggtcacaaagagccag
aaattccacgcggcggcggaggagatgaggataaacacagaaagaaaagttgaggttata
aaacccctagtggccgaagctgacacctcaaacagagcgacgttcgtggtcggcagctcc
tcttcactcattgcttcaccggaactggagacgcaggaacctgaaattgaacttcccctg
gagcctcggcccgacgaagaatgtctgcggatccttggggatgtggagaaaggtgcaaaa
ttccttagtgatgctgagatcatccaattagtcaatgctaagcatatcccagcctacaaa
ttggaatcactgatggaaacccatgaacgaggtgtatctattcgtcgacagttactttcc
acaaaacttccagagccttcttctctccagtatctgccttacagggactataactactcc
ttggtgatgggagcttgttgtgagaatgttattggctatatgcccatccctgttggagtg
gcaggacctctgtgcttggatggaaaagaatttcaggttccaatggcaaccacggaaggt
tgccttgtggccagcactaacagaggctgcagagcaataggccttggtggaggtgccagc
agccgaatccttgcagatgggatgacccgcggccccgtggtacgtcttccccgtgcttgt
gactctgcagaagtgaaggcctggcttgagacacctgaagggttcacagtgataaaggag
gcgttcgacagcaccagcaggtttgcgcgtctacagaaacttcacacgagtgtggcggga
cgcaatctttacatccgcttccagtccaggtcgggcgacgccatgggcatgaacatgatt
tcgaagggtacagagaaagcactttcaaaactccacgagtatttccctgacatgcagatt
ctggcagttagcggtaactattgcactgacaagaaacctgctgccatcaactggatagag
ggacgaggaaagtctgttgtttgtgaagctgtcattccagcccgggttgtcagagaagta
ttgaaaactactacggaagctatggttgaggtcaacattaataagaacctggtgggctct
gccatggctgggagcatcgggggctacaatgcccacgcggccaacatcgtgactgccatc
tacatcgcctgtgggcaggatgcagcacagaatgttggtagttcaaactgcattacttta
atggaagcaagtggccccacaaatgaagatctgtatatcagttgcaccatgccgtctata
gaaataggaactgtgggtggtggcaccaacctgctccctcagcaagcctgtttgcagatg
ctgggtgtgcaaggagcgtgcaaagagaatcctggggagaatgcgcggcagctggccagg
attgtgtgtgggacagtgatggctggggaattgtccctgatggcagccttggcagcagga
catcttgtcagaagtcacatgattcacaacaggtcaaaggtaaatctacaaggcctccag
ggcacttgcactgagaaggctgcttga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (3)   
   Pfam (3)   
All databases (36)   

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