KEGG   Equus caballus (horse): 100066422Help
Entry
100066422         CDS       T01058                                 

Gene name
CYP2E1
Definition
(RefSeq) cytochrome P450 2E1
  KO
K07415  cytochrome P450 family 2 subfamily E polypeptide 1 [EC:1.14.13.-]
Organism
ecb  Equus caballus (horse)
Pathway
ecb00140  Steroid hormone biosynthesis
ecb00590  Arachidonic acid metabolism
ecb00591  Linoleic acid metabolism
ecb00980  Metabolism of xenobiotics by cytochrome P450
ecb00982  Drug metabolism - cytochrome P450
ecb00983  Drug metabolism - other enzymes
ecb01100  Metabolic pathways
ecb04932  Non-alcoholic fatty liver disease (NAFLD)
ecb05204  Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:ecb00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    100066422 (CYP2E1)
   00590 Arachidonic acid metabolism
    100066422 (CYP2E1)
   00591 Linoleic acid metabolism
    100066422 (CYP2E1)
  Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    100066422 (CYP2E1)
   00982 Drug metabolism - cytochrome P450
    100066422 (CYP2E1)
   00983 Drug metabolism - other enzymes
    100066422 (CYP2E1)
 Human Diseases
  Cancers
   05204 Chemical carcinogenesis
    100066422 (CYP2E1)
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100066422 (CYP2E1)
Enzymes [BR:ecb01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-  
     100066422 (CYP2E1)
Cytochrome P450 [BR:ecb00199]
 Cytochrome P450, animal type
  CYP2 family
   100066422 (CYP2E1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: p450
Motif
Other DBs
NCBI-GeneID: 100066422
NCBI-ProteinID: NP_001104773
Ensembl: ENSECAG00000019088
VGNC: 50568
UniProt: A8WDL7
Position
1
AA seq 493 aa AA seqDB search
MAALGITVALLVWVATLLLISIWKQIYSSWNLPPGPFPLPIIGNLFHLDLKNIPKSFTRL
AERYGPVFTLYLGSQRVVVMHGYKAVKEVLLNYKNELSGRGEIAVFQAHKDNGVIFNNGP
SWKDTRRLSLTILRDYGMGKQRNEERIQRETHFLLEALRKTQGQPFDPTFVLGGGPFNVI
ADILFHKHFDYEDKTCQRLMHLFNENFYLLSTPWLQAYNYFSTYLRYLPGSHRKVMKNVS
EIKEFTSERVKEHHKSLDPNCPRDFTDNLLMEMEKEKHSAEPLFTLENITVTTADMFFAG
TETTSTTLRYGLLILLKHPEVEEKLHKEIDSVIGPSRIPAFKDRLEMPYMDAVVHEIQRF
INLVPSNLPHVATQDTAFRGYVIPKGTVVIPTLDSLLYDNQEFPDAEKFKPEHFLNENGK
FKYSDHFKAFSAGKRVCVGEGLARMELFLFLTAILQHFNLKSLVDPKDIDLSPVTIGFGN
IPPNYKLCIIPRS
NT seq 1482 nt NT seq  +upstreamnt  +downstreamnt
atggctgccctgggcatcacggtggccctgctggtgtgggtggccaccctgctgctcatc
tccatctggaagcagatctacagcagctggaacctgccccctggtcctttcccactgccc
atcattgggaatcttttccacttggacctcaagaatattcccaagtccttcaccaggctg
gcagagcggtacgggccggtgttcaccctgtacctgggctcgcagcgcgtcgtggtcatg
catggctacaaggccgtgaaggaggtcctgctcaactacaagaatgagttgtccggcagg
ggagaaatcgccgtgttccaggcgcacaaggacaatggagttattttcaataatggacca
agctggaaggacacccggcggctctccctgactatcctccgagactatgggatggggaag
cagcgcaacgaggagcggatccagagggaaacccacttcctgctggaggccctcaggaag
acccagggccagcccttcgaccccacctttgtccttggcggcgggcccttcaacgtcatc
gccgacatcctcttccacaagcactttgactacgaggacaagacgtgtcagaggctgatg
cacttgttcaacgagaacttctacttgctcagcaccccctggctccaggcttataattat
ttttcaacctatctgcgctacctgcctggaagccatagaaaagtaatgaaaaatgtgtct
gaaattaaagagtttacttcagaaagagtgaaggagcaccataagtcactggaccccaac
tgcccccgagacttcaccgacaacctgctcatggaaatggagaaggagaaacacagtgcg
gagcccctgtttacgttggaaaacatcactgtgaccacggctgacatgttctttgcaggg
acagagaccaccagcaccacgctgagatacgggctcctgattctcttgaaacacccggag
gttgaagagaaacttcataaagagattgacagtgtgattgggccaagccgaatccctgcc
ttcaaggacagactagagatgccctacatggatgctgtggtgcatgagattcagcgattc
atcaacctcgtgccctccaacctgccccatgtagcaacccaggacacagcgttcagagga
tatgtcatccctaagggcacagtcgtaattccgacactggattcactcttgtatgacaac
caagagttccctgatgcagagaagtttaagccagagcactttctgaacgaaaacggaaag
ttcaagtacagcgaccatttcaaggcattttccgcaggaaagcgcgtgtgcgtcggagaa
ggcctggctcgcatggagctgtttctgttcctgactgccattctgcagcactttaacttg
aagtctctggttgaccccaaggatattgacctcagccccgtcacgattgggtttggcaac
atcccacccaattacaagctctgcatcattccccgctcgtga

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