KEGG   Equus caballus (horse): 100146249
Entry
100146249         CDS       T01058                                 
Symbol
IRS2
Name
(RefSeq) insulin receptor substrate 2 isoform X1
  KO
K07187  insulin receptor substrate 2
Organism
ecb  Equus caballus (horse)
Pathway
ecb04022  cGMP-PKG signaling pathway
ecb04068  FoxO signaling pathway
ecb04140  Autophagy - animal
ecb04152  AMPK signaling pathway
ecb04211  Longevity regulating pathway
ecb04213  Longevity regulating pathway - multiple species
ecb04910  Insulin signaling pathway
ecb04920  Adipocytokine signaling pathway
ecb04923  Regulation of lipolysis in adipocytes
ecb04930  Type II diabetes mellitus
ecb04931  Insulin resistance
ecb04932  Non-alcoholic fatty liver disease
ecb04935  Growth hormone synthesis, secretion and action
ecb05010  Alzheimer disease
ecb05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ecb00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    100146249 (IRS2)
   04022 cGMP-PKG signaling pathway
    100146249 (IRS2)
   04152 AMPK signaling pathway
    100146249 (IRS2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100146249 (IRS2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    100146249 (IRS2)
   04923 Regulation of lipolysis in adipocytes
    100146249 (IRS2)
   04920 Adipocytokine signaling pathway
    100146249 (IRS2)
   04935 Growth hormone synthesis, secretion and action
    100146249 (IRS2)
  09149 Aging
   04211 Longevity regulating pathway
    100146249 (IRS2)
   04213 Longevity regulating pathway - multiple species
    100146249 (IRS2)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    100146249 (IRS2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100146249 (IRS2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100146249 (IRS2)
   04932 Non-alcoholic fatty liver disease
    100146249 (IRS2)
   04931 Insulin resistance
    100146249 (IRS2)
SSDB
Motif
Pfam: IRS PH PH_11 MEKK4_N
Other DBs
NCBI-GeneID: 100146249
NCBI-ProteinID: XP_023477591
Position
17:complement(77113371..77144609)
AA seq 1401 aa
MASPPLHGPPGPAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA
TATAGGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTK
DEYFAVAAENEQEQEGWYRALTDLVSEGRAGAGDAPPAAATAASCSASLPGALGGSAGAA
AADDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSV
TLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELF
EFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSS
CRVRTASEGDGGAAAGTGAAGGRPVSVSGSPLSPGPVRAPLSRSHTLSGGCGGRAGKVTL
APAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPHLQHPLHLPAG
QRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGSGGEL
YGYMTMDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYT
LMRATFSGSSGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGTDDGYMPMTPG
VALMGGGSGSCRSDDYMPMSPTSVSAPKQILQPRAAAAALPPTGAAAPAPASAAGRAFPV
NGGSYKASSPAESSPEDSGYMRMWCGSKLSMENADSKLLPNGDYLNMSPSDAGPSGTPPD
FFSAALHNSGETLRGVPGYCYSSLPRSYKAPYTCDGDHDQYVLMSSPVGRILEEERLEPQ
ASPGTTPSASAFATGAGGGGHTQPPHPVVPSPGRPSGGGSGRPEGFLNQRCRAVRPTRLS
LEGLPTLPSMHEYPLPPEPKSPGEYINIDFGESGARLSPPAPPLLASAASSSSLLSASSP
ASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGTQSGDPVGSLDALLSPEASSPY
PPLPPRPVAPSSSLQPLAPPPPPPGELYRLPPASTSQGPGAASSSSSETGDNGDYTEMAF
GVAATPPQPIAAPPKPEGARVTSPTSGVKRLSLMDQVSGVEAFLQASQPPDPHRGAKVIR
ADPQGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGGGSILGGG
DEPPASPRQLQPPVPQQARPWTPSQPGGLVGCPGGTGSPMRRETSAGFQNGLNYIAIDVR
DEPPPQQHPQHPQHPQPGDKSAWGRTRSLGGLISAVGGSSTGGVCGGPGPGALPSANTYA
SIDFLSHHLKEATVVKEMDSGGPKWSSEENSGGRVKICLALSHDVTHQRMTLTGDAQHFL
KSEAAYNFLLDLSNDYVLKHL
NT seq 4206 nt   +upstreamnt  +downstreamnt
atggcgagcccgccgctgcacgggccccccgggccagcgggcggcgacggccccaacctc
aacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcaa
aagcacggccacaagcgcttcttcgtgctgcgcgggcccggcgcgggcggcgacgaggcg
acggcgacagcgggcggggggccggcgccgcagccgccgcggctcgagtactacgagagc
gagaagaagtggcggagcaaggcgggcgccccgaagcgggtcatcgcgctcgactgctgc
ctgaacatcaacaagcgcgccgacgccaaacacaagtacctgatcgccctctacaccaag
gacgagtacttcgccgtggcggccgagaacgagcaggagcaggagggctggtaccgcgcg
ctcaccgacctggtcagcgagggccgcgcgggcgccggcgacgcgccccccgccgccgcc
accgccgcgtcctgcagcgcctccctgcccggcgccctgggcggctcggccggcgccgcc
gcggccgatgacagctacgggctggtggcgcccgccacggccgcctaccgcgaggtgtgg
caggtgaacctcaagcccaagggcttgggccagagcaagaacctgacgggcgtgtaccgc
ctgtgcctgtcggcgcgcaccatcggcttcgtgaagctcaactgcgagcagccgtcggtg
acgctgcagctcatgaacatccgccgctgcggccactcggacagcttcttcttcatcgag
gtgggccgctcggccgtcacgggccccggcgagctgtggatgcaggccgacgactcggtg
gtggcgcagaacatccacgagaccatcctggaggccatgaaggcgctcaaggagctcttc
gagttccggccgcgcagcaagagccagtcgtcgggctcgtcggccacgcaccccatcagc
gtccccggagcgcgccgccaccaccacctggtcaacctgccccccagccagacgggcctg
gtgcgccgctcgcgcaccgacagcctggccgccaccccgccggccgccaagtgcagttcc
tgtcgggtgcgcacagccagcgagggcgacggcggcgcggcggcggggaccggggcggcg
ggcggcaggcccgtgtcggtgtcggggagccccctgagccccgggccggtgcgcgcgccg
ctgagccgctcgcacaccctgagcggcggctgcggcggccgcgcgggcaaggtgacgctg
gcgccggcagggggcgccctgcaacacagccgctccatgtccatgcccgtggcgcactcg
cccccggccgccaccagccccggcagcctgtcgtccagcagcgggcacggctcgggctcc
tacccgccgcctccgggcccgcacccgcacctgcagcaccccctgcatctccccgcgggc
cagagaccctccagcggcagcgcctcggcctcgggctcccccagcgaccccggcttcatg
tccctggacgagtacggctccagccctggggacctgagagccttctgcagccaccggagc
aacacgccggagtccatcgccgagacccccccggccagggacggcagcgggggggagctg
tacgggtacatgaccatggacaggcccctgagccactgtggccgtccctaccgccgcgtc
tcaggggacggggcccaggacttggacagagggctgaggaagaggacttactccctgacg
acacctgctcggcagcggccggtgccccagccctcctccgcgtccctggatgaatacacc
cttatgcgggccaccttctccggcagctccggccgactctgcccgtcctgccccgcgtcc
tctcccaaagtggcttaccacccctatcccgaggactacggcgacatcgaaattgggtcc
cataggagctccagcagtaacctgggcacggacgatggctacatgcccatgacccctggc
gtggctctcatggggggtggcagtggtagctgcaggagtgacgactacatgcccatgagc
cccaccagcgtgtctgcccccaagcaaatcctgcagcctcgcgctgccgccgccgccttg
ccccccacgggagctgcggcgcctgcgcccgcctccgcggccggcagggcctttccagtg
aacggtggcagctacaaggccagctccccggccgagagctcccccgaggacagtgggtac
atgcgcatgtggtgtggctccaagctgtccatggagaacgccgacagcaagctgcttccc
aacggggactacctcaacatgtcccccagcgacgcgggcccctcggggaccccgcccgac
ttcttctccgcagccttgcacaacagcggggagacgctcaggggcgtccctggctactgc
tacagctccctgcctcgctcctacaaggctccctacacctgcgatggggaccacgaccag
tacgtgctcatgagctcccccgtggggcgcatcctggaagaggagcgactggagccgcag
gccagcccggggaccacgccgtcggccagcgccttcgccaccggggccggtgggggcggc
cacacgcagcctcctcacccagtagtgccttcgcccgggaggccgagtggcggcggcagt
ggccgcccggagggcttcctgaaccagcgctgccgggcagtgcggcccacgcgcctgtcc
ctggagggccttccgaccctgcccagcatgcacgagtaccctctgccgcccgagcccaag
agccccggcgagtacatcaacatcgacttcggcgagtcaggagcgcgcctgtcgccgccg
gcccctccgctgctcgcctcggcggcctcgtcctcctcgctgctgtccgccagcagccca
gcctcatccctgggctcgggcaccccgggcacgagcagcgacagccggcagcgctccccg
ctctccgactacatgaacctcgacttcagctcgcccaagtctcccaagccgggtacccag
agcggggaccctgtgggctccttggatgccctcctgtcccccgaggcctcgtccccgtac
ccaccgctgcccccgcgccctgtcgccccctcctcctccctgcagccgctggccccccct
ccgccacccccaggggagctgtaccgcctgcctccagcatccacctcccagggccccggc
gccgcctcctcttcgtcctcggagactggggacaatggtgactacaccgagatggccttt
ggcgtggctgccaccccgccacaacccatcgcggccccccccaagccagaaggtgcccgc
gtgaccagccccacgtccggcgtgaagaggctgagtctcatggatcaggtgtcgggggtc
gaggccttccttcaggccagccagcccccagacccgcaccgaggggccaaggtcatccgc
gcagacccgcaggggggccgccgccgccacagctccgagaccttctcctcgaccaccact
gtgacccccgtgtccccgtctttcgcccacaacccgaagcgccataactcggcctctgtg
gaaaacgtttctctcaggaaaagcagcgaagggggcggcggcagcatcctcggtggggga
gatgagccccctgcgtccccccgccagttgcagccaccggtcccccagcaggcgcggccg
tggacaccgagtcagcctggtggcttggttggctgccccggcggcactggctctccaatg
cgcagggagacctctgccggcttccagaacggcctcaactacatcgccatcgacgtgagg
gacgagccgcccccgcagcagcacccgcagcatccacagcatccgcagccgggagacaaa
agcgcctggggccggacccggagccttgggggtctcatcagcgccgtggggggcagcagc
acgggcggggtgtgtggggggccgggccctggtgccctgccatccgccaacacctatgcc
agcattgacttcttgtcgcatcacctgaaggaggccacggttgtgaaagaaatggacagt
ggtggccccaaatggagcagtgaggaaaattctgggggaagagtgaagatctgtctggct
ttatcacatgacgtcacacatcagagaatgacattaacaggagatgctcagcatttttta
aaatctgaagctgcttacaattttcttttggatctgagcaatgactacgttttgaaacat
ctgtga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (15)   
   KEGG PATHWAY (15)   
Genome (1)   
   KEGG GENOME (1)   
Gene (41)   
   KEGG ORTHOLOGY (1)   
   RefGene (37)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (4)   
   Pfam (4)   
All databases (66)   

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