KEGG   Escherichia coli O25b K100 H4-ST131 EC958 (UPEC): EC958_0135
Entry
EC958_0135        CDS       T04373                                 
Symbol
thrA
Name
(GenBank) aspartokinase I
  KO
K12524  bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]
Organism
ecos  Escherichia coli O25b:K100:H4-ST131 EC958 (UPEC)
Pathway
ecos00260  Glycine, serine and threonine metabolism
ecos00261  Monobactam biosynthesis
ecos00270  Cysteine and methionine metabolism
ecos00300  Lysine biosynthesis
ecos01100  Metabolic pathways
ecos01110  Biosynthesis of secondary metabolites
ecos01120  Microbial metabolism in diverse environments
ecos01230  Biosynthesis of amino acids
Module
ecos_M00016  Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
ecos_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
ecos_M00018  Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:ecos00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    EC958_0135 (thrA)
   00270 Cysteine and methionine metabolism
    EC958_0135 (thrA)
   00300 Lysine biosynthesis
    EC958_0135 (thrA)
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    EC958_0135 (thrA)
Enzymes [BR:ecos01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.3  homoserine dehydrogenase
     EC958_0135 (thrA)
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.2  Phosphotransferases with a carboxy group as acceptor
    2.7.2.4  aspartate kinase
     EC958_0135 (thrA)
SSDB
Motif
Pfam: Homoserine_dh AA_kinase NAD_binding_3 ACT_7 ACT DUF6247
Other DBs
NCBI-ProteinID: CDN80371
UniProt: A0AA36KUM3
Position
337..2799
AA seq 820 aa
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDA
LPNISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASRIP
ADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRD
EDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLITQSSSEYSISF
CVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELAQAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRYAAEKSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGKLDEGMSFSEATTLA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELADIEIEPVLPAEFNAEGDVAAFMA
NLSQLDDLFAARVAKARDEGKVLRYVGNIDEDGVCRVKIAEVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq 2463 nt   +upstreamnt  +downstreamnt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgggtt
gccgatattctggaaagcaatgccaggcaggggcaggtggcgaccgtcctctctgccccc
gccaaaattaccaaccatctggtagcgatgattgaaaaaactattagcggccaggatgct
ttacccaatatcagcgatgccgaacgtatttttgccgaacttctgacgggactcgccgcc
gcccagccgggatttccgctggcacaattgaaaactttcgtcgaccaggaatttgcccaa
ataaaacatgtcctgcatggcatcagtttgttggggcagtgcccggatagcatcaacgct
gcgctgatttgccgtggcgagaaaatgtcgatcgccattatggccggcgtgttagaagcg
cgtggtcacaacgttaccgttatcgatccggtcgaaaaactgctggcagtgggtcattac
ctcgaatctaccgttgatattgctgaatccacccgccgtattgcggcaagccgcattccg
gctgaccacatggtgctgatggctggtttcactgccggtaatgaaaaaggcgagctggtg
gttctgggacgcaacggttccgactactccgctgcggtgctggcggcctgtttacgcgcc
gattgttgcgagatctggacggatgttgacggtgtttatacctgcgatccgcgtcaggtg
cccgatgcgaggttgttgaagtcgatgtcctatcaggaagcgatggagctttcttacttc
ggcgctaaagttcttcacccccgcaccattacccccatcgcccagttccagatcccttgc
ctgattaaaaataccggaaatcctcaagcaccaggtacgctcattggtgccagccgtgat
gaagacgaattaccggtcaagggcatttccaatctgaataacatggcaatgttcagcgtt
tccggcccggggatgaaagggatggttggcatggcggcgcgcgtctttgcagcgatgtca
cgcgcccgtatttccgtggtgctgattacgcaatcatcttccgaatacagtatcagtttc
tgcgttccgcaaagcgactgtgtgcgagctgaacgggcaatgcaggaagagttctacctg
gaactgaaagaaggcttactggagccgttggcggtgacggaacggctggccattatctcg
gtggtaggtgatggtatgcgcaccttacgtgggatctcggcgaaattctttgccgcgctg
gcccgcgccaacatcaatattgtcgccattgctcagggatcttctgaacgctcaatctct
gtcgtggtcaataacgatgatgcgaccactggcgtgcgcgttactcatcagatgctgttc
aataccgatcaggttatcgaagtgtttgtgattggcgtcggtggcgttggcggtgcgctg
ctggagcaactgaagcgtcagcaaagctggttgaagaataaacatatcgacttacgtgtc
tgcggtgttgctaactcgaaggcactgctcaccaatgtacatggccttaatctggaaaac
tggcaggaagaactggcgcaagccaaagagccgtttaatctcgggcgcttaattcgcctc
gtgaaagaatatcatctgctgaacccggtcattgttgactgtacttccagccaggctgtg
gcagatcaatatgccgacttcctgcgcgaaggtttccacgttgttacgccgaacaaaaag
gccaacacctcgtcgatggattactaccatcagttgcgttatgcggcggaaaaatcgcgg
cgtaaattcctctatgacaccaacgttggggctggattaccggttattgagaacctgcaa
aatctgctcaatgctggtgatgaattgatgaagttctccggcattctttcaggttcgctt
tcttatatcttcggcaagttagacgaaggcatgagtttctccgaggcgaccacactggcg
cgggaaatgggttataccgaaccggacccgcgagatgatctttctggtatggatgtggcg
cgtaaactattgattctcgctcgtgaaacgggacgtgaactggagttggcggatattgaa
attgaacctgtgctgcccgcagagtttaacgccgagggtgatgttgccgcttttatggcg
aatctgtcacagctcgacgatctctttgccgcgcgtgtggcgaaggctcgtgatgaagga
aaagttttgcgctatgttggcaatattgatgaagatggcgtctgccgcgtgaagattgcc
gaagtggatggtaatgatccgctgttcaaagtgaaaaatggcgaaaacgccctggccttc
tatagccactattatcagccgctgccgttggtactgcgcggatatggtgcgggcaatgac
gttacagctgccggtgtctttgctgatctgctacgtaccctctcatggaagttaggagtc
tga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (13)   
   KEGG PATHWAY (8)   
   KEGG MODULE (5)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (2)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (6)   
   Pfam (6)   
All databases (42)   

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