KEGG   Escherichia coli O18 K1 H7 IHE3034 (ExPEC): ECOK1_2548
Entry
ECOK1_2548        CDS       T01997                                 
Symbol
folC
Name
(GenBank) tetrahydrofolate synthase/dihydrofolate synthase
  KO
K11754  dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]
Organism
eih  Escherichia coli O18:K1:H7 IHE3034 (ExPEC)
Pathway
eih00790  Folate biosynthesis
eih01100  Metabolic pathways
eih01240  Biosynthesis of cofactors
Module
eih_M00126  Tetrahydrofolate biosynthesis, GTP => THF
Brite
KEGG Orthology (KO) [BR:eih00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    ECOK1_2548 (folC)
Enzymes [BR:eih01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.12  dihydrofolate synthase
     ECOK1_2548 (folC)
    6.3.2.17  tetrahydrofolate synthase
     ECOK1_2548 (folC)
SSDB
Motif
Pfam: Mur_ligase_M Mur_ligase_C
Other DBs
NCBI-ProteinID: ADE90356
Position
complement(2642258..2643526)
AA seq 422 aa
MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSQVAARLGVLKPAPFVFTVAGTNGK
GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPKSAHTASFAEIESARGDIS
LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD
RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWTFSD
AHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI
FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP
RGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSG
GK
NT seq 1269 nt   +upstreamnt  +downstreamnt
atgattatcaaacgcactcctcaagccgcgtcgcctctggcttcgtggctttcttatctg
gaaaacctgcacagtaaaactatcgatctcggccttgagcgcgtgagccaggtcgcggcg
cgtcttggcgttctgaaaccagcgccatttgtgtttaccgttgcgggtactaatggcaaa
ggcaccacctgccgtacgctggagtcgattctgatggcggcagggtacaaagtgggcgtc
tacagttcgccgcatctggtgcgttataccgagcgcgtacgtgtgcagggtcaggaattg
ccgaaatcggcccacaccgcttcttttgcggagattgaatcggcacgcggtgatatttcc
ctgacctatttcgagtacggtacgctctcggcgttgtggctgttcaagcaggcacaactt
gacgtagtgattctggaagtagggctgggcggtcgtctggacgcaaccaatattgtcgat
gccgatgtcgcggtagtaaccagtattgcgctggatcataccgactggctggggccagat
cgtgaaagtattggtcgcgagaaagcaggtatctttcgcagcgaaaaaccggcaattgtc
ggtgagccggagatgccttctaccattgctgatgtggcgcaggaaaaaggtgcactgcta
caacgtcggggcgttgagtggaactattccgtcaccgatcatgactggacgtttagcgat
gctcacggcacgctggaaaatctgccgttgccgcttgtcccgcaaccgaatgccgcaacg
gcgctggcggcactgcgtgccagcgggctggaggtcagtgaaaatgccattcgcgacggg
attgccagcgcaattttgccgggacgtttccagattgtgagcgagtcgccacgcgttatt
tttgatgtcgcgcataatccacatgcggcggaatatctcaccgggcgtatgaaagcgcta
ccgaaaaacgggcgcgtgctggcggttatcggtatgctacatgataaagatattgccgga
actctggcctggttgaaaagcgtggttgatgactggtattgtgcgccactggaagggccg
cgcggtgccacggcagaacaactgcttgagcatttgggtaacggcaaatcatttgatagc
gttgcgcaggcatgggatgccgcaatggcggacgctaaagcggaagacaccgtgctggtg
tgtggttcgttccacacggtcgcacatgtcatggaagtgattgacgcgaggagaagcggt
ggcaagtaa

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