KEGG   Escherichia coli O44 H18 042 (EAEC): EC042_2498Help
Entry
EC042_2498        CDS       T02067                                 

Gene name
arnA
Definition
(GenBank) bifunctional polymyxin resistance protein [includes: UDP-4-amino-4-deoxy-l-arabinose formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating]
  KO
K10011  UDP-4-amino-4-deoxy-L-arabinose formyltransferase / UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) [EC:2.1.2.13 1.1.1.305]
Organism
elo  Escherichia coli O44:H18 042 (EAEC)
Pathway
elo00520  Amino sugar and nucleotide sugar metabolism
elo01100  Metabolic pathways
elo01503  Cationic antimicrobial peptide (CAMP) resistance
Module
elo_M00761  Undecaprenylphosphate alpha-L-Ara4N biosynthesis, UDP-GlcA => undecaprenyl phosphate alpha-L-Ara4N
Brite
KEGG Orthology (KO) [BR:elo00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00520 Amino sugar and nucleotide sugar metabolism
    EC042_2498 (arnA)
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01503 Cationic antimicrobial peptide (CAMP) resistance
    EC042_2498 (arnA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01005 Lipopolysaccharide biosynthesis proteins [BR:elo01005]
    EC042_2498 (arnA)
Enzymes [BR:elo01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.305  UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)
     EC042_2498 (arnA)
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.13  UDP-4-amino-4-deoxy-L-arabinose formyltransferase
     EC042_2498 (arnA)
Lipopolysaccharide biosynthesis proteins [BR:elo01005]
 Unusual sugar
  EC042_2498 (arnA)
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif
Pfam: Epimerase GDP_Man_Dehyd Formyl_trans_N Formyl_trans_C 3Beta_HSD NAD_binding_10 NAD_binding_4 RmlD_sub_bind
Motif
Other DBs
NCBI-ProteinID: CBG35330
UniProt: D3H1C2
Structure
PDB: 

Position
2642413..2644395
Genome map
AA seq 660 aa AA seqDB search
MKTVVFAYHDMGCLGIEALLAAGYEISAIFTHTDNPGEKAFYGSVARLAAERGIPVYAPD
NVNHPLWVERIAQLSPEVIFSFYYRHLICDEILQLAPAGAFNLHGSLLPKYRGRAPLNWV
LVNGETETGVTLHRMVKRADAGAIVAQLRIAIAPDDIAITLHHKLCHAARQLLEQTLPTI
KHGNILEIAQRENEATCFGRRTPEDSFLEWHKPASVLHNMVRAVADPWPGAFSYVGNQKF
TVWSSRVHSHAPAAQPGSVISVAPLLIACGDGALEIVTGQAGDGITMQGSQLAQTLGLVQ
GSRLNSQPACTARRRTRVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRFLNHP
HFHFVEGDISIHSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYC
VKYRKRIIFPSTSEVYGMCSDKYFDEDHSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEK
EGLQFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIDGGKQKRCFTDI
RDGIEALYRIIENAGNRCDGEIINIGNPDNEASIEELGEMLLASFEKHPLRHHFPPFAGF
RVVESSSYYGKGYQDVEHRKPSIRNARRCLDWEPKIDMQETIDETLDFFLRTVDLTDKPS
NT seq 1983 nt NT seq  +upstreamnt  +downstreamnt
atgaaaaccgtcgtttttgcctaccacgatatgggatgcctcggtattgaagccctgctg
gctgccggttacgaaattagcgccatttttacccataccgataatcccggtgaaaaagcc
ttttatggttcggtggctcgtctggcggcggaaagaggcattccggtttatgcgccggat
aacgttaatcatccgctgtgggtggaacgtattgcccaactctcaccagaggtgattttc
tctttttattatcgccatcttatttgcgacgagattttgcagctcgctcccgcaggtgca
tttaatctgcatggttcgctgttaccaaaatatcgtggtcgcgcgccgctgaactgggtg
ctggtgaacggtgaaacggaaactggcgttacattgcaccgaatggtgaaacgtgccgat
gccggggccattgtggcgcaactgcgcattgccattgcgccagacgatatcgccattacg
ctgcatcataagttatgtcatgccgcgcgccagctactggagcagacattacccaccatt
aaacacggtaatattctggaaatcgcccagcgcgaaaacgaagccacctgttttggtcgc
agaacaccggaagacagtttcctcgaatggcataaaccggcatccgtgctgcacaacatg
gtgcgtgccgttgccgatccgtggccgggtgccttcagctatgttggtaatcagaaattt
accgtctggtcgtcacgcgtgcattctcatgcgcctgcagcacagccggggagcgtgatt
tctgtagcgccactgctgattgcctgtggcgatggcgcgctggaaatcgtcaccggacag
gcgggcgacggcattactatgcagggctcgcaattagcgcagacgctgggcctggtgcaa
ggttcacgcttgaatagccagcctgcctgcaccgcccgacgccgtacccgggtactcatc
ctcggggtgaatggctttattggcaaccatctgacagaacgcctgctgcgcgaagatcat
tatgaagtttacggtctggatattggcagcgatgcgataagccgttttctgaatcatccg
cattttcactttgtcgaaggcgatatcagtattcattccgaatggattgagtatcacgtc
aaaaaatgtgatgtcgtcttgccgctggtggcgatagccacgccgattgaatatacccgc
aacccactgcgcgtatttgaactcgattttgaagagaatctacgcattatccgctactgc
gtgaagtaccgtaagcgaatcatcttcccgtcgacttcagaagtttatgggatgtgtagc
gataaatacttcgatgaggaccattctaatttaatcgtcggcccggtgaataaaccacgc
tggatttattcggtgtctaaacaattacttgatcgagtgatctgggcctatggcgaaaaa
gagggtttacagttcaccctcttccgcccgtttaactggatggggccacgactggataac
cttaatgcagcgcgaattggcagctcccgcgctattacgcaactcattctcaatctggta
gaaggttcaccgattaagctgattgatggcggaaaacaaaaacgctgctttactgatatt
cgcgatggtatcgaggcgttataccgcatcatcgaaaatgcgggaaatcgctgcgacggc
gaaattatcaacattggcaatcctgataacgaagcgagcattgaggaactgggcgagatg
ctgctggcgagcttcgaaaaacatccgctgcgccatcacttcccaccgtttgcgggcttt
cgcgttgtcgaaagtagcagctactacggcaaaggatatcaggacgtagagcatcgtaaa
ccaagcatccgcaatgcccgccgctgcctggactgggagccgaaaattgatatgcaggaa
accatcgacgaaacgctggatttcttcctgcgcaccgttgatcttacggataaaccatca
tga

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