KEGG   ENZYME: 1.1.1.112Help
Entry
EC 1.1.1.112                Enzyme                                 

Name
indanol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
indan-1-ol:NAD(P)+ 1-oxidoreductase
Reaction(IUBMB)
indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+ [RN:R03582 R03583]
Reaction(KEGG)
Substrate
indan-1-ol [CPD:C01710];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
indanone [CPD:C01504];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
3(20)alpha-Hydroxysteroids are also oxidized, more slowly.
History
EC 1.1.1.112 created 1972
Reference
1  [PMID:4397102]
  Authors
Billings RE, Sullivan HR, McMahon RE.
  Title
The dehydrogenation of 1-indanol by a soluble oxidoreductase from bovine liver.
  Journal
J Biol Chem 246:3512-7 (1971)
Reference
2  [PMID:2559080]
  Authors
Hara A, Nakagawa M, Taniguchi H, Sawada H.
  Title
3(20)alpha-hydroxysteroid dehydrogenase activity of monkey liver indanol dehydrogenase.
  Journal
J Biochem (Tokyo) 106:900-3 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.112
IUBMB Enzyme Nomenclature: 1.1.1.112
ExPASy - ENZYME nomenclature database: 1.1.1.112
BRENDA, the Enzyme Database: 1.1.1.112
CAS: 37250-43-4

KEGG   ENZYME: 1.1.1.149Help
Entry
EC 1.1.1.149                Enzyme                                 

Name
20alpha-hydroxysteroid dehydrogenase;
20alpha-hydroxy steroid dehydrogenase;
20alpha-HSD;
20alpha-HSDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase
Reaction(IUBMB)
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ = 17alpha-hydroxyprogesterone + NAD(P)H + H+ [RN:R03325]
Reaction(KEGG)
Substrate
17alpha,20alpha-dihydroxypregn-4-en-3-one [CPD:C04518];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
17alpha-hydroxyprogesterone [CPD:C01176];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Re-specific with respect to NAD(P)+ (cf. EC 1.1.1.62 17beta-estradiol 17-dehydrogenase).
History
EC 1.1.1.149 created 1972, deleted 1983, reinstated 1986
Pathway
ec00140  Steroid hormone biosynthesis
Orthology
K00212  20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
K05295  20alpha-hydroxysteroid dehydrogenase
Genes
HSA: 1645(AKR1C1)
PTR: 100607996
PPS: 100986729(AKR1C1)
GGO: 101146324(AKR1C1)
PON: 100171658(AKR1C1)
NLE: 100605934(AKR1C1)
MCC: 711198(AKR1C1)
MCF: 101865536(AKR1C1)
CSAB: 103237807
RRO: 104678924
RBB: 108532991
CJC: 100404656(AKR1C1)
SBQ: 101042532
MMU: 105349(Akr1c18)
RNO: 171516(Akr1c3) 307092(Akr1c1)
CGE: 100768666
HGL: 101716553
CCAN: 109680485
ECB: 100070570
EPZ: 103540778
 » show all
Taxonomy
Reference
1  [PMID:4382486]
  Authors
Shikita M, Inano H, Tamaoki B.
  Title
Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes.
  Journal
Biochemistry 6:1760-4 (1967)
Reference
2  [PMID:6935192]
  Authors
Strickler RC, Tobias B, Covey DF.
  Title
Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site.
  Journal
J Biol Chem 256:316-21 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.149
IUBMB Enzyme Nomenclature: 1.1.1.149
ExPASy - ENZYME nomenclature database: 1.1.1.149
BRENDA, the Enzyme Database: 1.1.1.149
CAS: 9040-08-8

KEGG   ENZYME: 1.3.1.20Help
Entry
EC 1.3.1.20                 Enzyme                                 

Name
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;
dihydrodiol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase
Reaction(IUBMB)
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ [RN:R00814]
Reaction(KEGG)
R00814;
(other) R07015 R09420
Show
Substrate
trans-1,2-dihydrobenzene-1,2-diol [CPD:C04221];
NADP+ [CPD:C00006]
Product
catechol [CPD:C00090];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.3.1.20 created 1972
Pathway
ec00980  Metabolism of xenobiotics by cytochrome P450
Orthology
K00078  dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP)
K00212  20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
Genes
HSA: 1645(AKR1C1) 27294(DHDH)
PTR: 100607996 456194(DHDH)
PPS: 100986729(AKR1C1) 100991467(DHDH)
GGO: 101146324(AKR1C1) 101152398(DHDH)
PON: 100171658(AKR1C1) 100174691(DHDH)
NLE: 100591778(DHDH) 100605934(AKR1C1)
MCC: 711198(AKR1C1) 718930(DHDH)
MCF: 101865536(AKR1C1) 102133381(DHDH)
CSAB: 103235003(DHDH) 103237807
RRO: 104666542(DHDH) 104678924
RBB: 108523635(DHDH) 108532991
CJC: 100390604(DHDH) 100404656(AKR1C1)
SBQ: 101042532 101049549(DHDH)
MMU: 71755(Dhdh)
RNO: 307092(Akr1c1) 691002(Dhdh)
CGE: 100753544(Dhdh)
NGI: 103743638(Dhdh)
HGL: 101713222(Dhdh) 101716553
CCAN: 109680485 109682683(Dhdh)
OCU: 100008610(DHDH)
TUP: 102470508(DHDH)
CFA: 403786(DHDH)
AML: 100477136(DHDH)
UMR: 103657108(DHDH)
ORO: 101371357(DHDH)
FCA: 101101272(DHDH)
PTG: 102948867(DHDH)
AJU: 106988698(DHDH)
BTA: 617564(DHDH)
BOM: 102280401(DHDH)
BIU: 109571974 109572213(DHDH)
PHD: 102323268(DHDH)
CHX: 102188075(DHDH)
OAS: 101103175(DHDH)
SSC: 397337(DHDH)
CFR: 102512639(DHDH)
CDK: 105102891(DHDH)
BACU: 103008204(DHDH)
ECB: 100051521(DHDH) 100070570
EPZ: 103540778 103553311(DHDH)
EAI: 106838267(DHDH)
MYB: 102262437(DHDH)
MYD: 102770117(DHDH)
HAI: 109391066(DHDH)
RSS: 109452566(DHDH)
PALE: 102885391(DHDH)
LAV: 100660549(DHDH)
TMU: 101355202
MDO: 100030403(DHDH)
SHR: 111720213(DHDH)
GGA: 777348(DHDH)
MGP: 104916162(DHDH)
CJO: 107325868(DHDH)
PHI: 102104923(DHDH)
PMAJ: 107199051(DHDH)
CCAE: 111946095(DHDH)
ASN: 102376323(DHDH)
AMJ: 102574630(DHDH)
PSS: 102447655(DHDH)
CMY: 102931206
XLA: 108697264 444539(dhdh)
XTR: 100145807(dhdh) 448579(dhdh)
DRE: 406433(dhdhl) 449558(zgc:101723)
SGH: 107553352 107595342(dhdh)
IPU: 100528487(dhdh)
MZE: 101466663
NFU: 107381267(dhdh) 107381268
MALB: 109955837(dhdh)
SFM: 108930140
LCM: 102353287(DHDH)
CMK: 103189533(dhdh)
CIN: 100186038
DME: Dmel_CG13280(CG13280) Dmel_CG3597(CG3597) Dmel_CG3609(CG3609)
DSI: Dsimw501_GD11964(Dsim_GD11964) Dsimw501_GD22839(Dsim_GD22839) Dsimw501_GD22840(Dsim_GD22840)
MDE: 101900891
AAG: 5572674
AME: 412231
BIM: 100740559
BTER: 100649548
SOC: 105208047
AEC: 105154186
ACEP: 105622679
HST: 105186645
DQU: 106741522
LHU: 105671479
PGC: 109857477
PCF: 106785709
NVI: 100117805
MDL: 103578346
NVL: 108560837
ZNE: 110838823
CRG: 105323672
EPA: 110244148
ADF: 107341873
HMG: 100210586
SPAR: SPRG_05860
 » show all
Taxonomy
Reference
1  [PMID:13651190]
  Authors
AYENGAR PK, HAYAISHI O, NAKAJIMA M, TOMIDA I.
  Title
Enzymic aromatization of 3,5-cyclohexadiene-1,2-diol.
  Journal
Biochim Biophys Acta 33:111-9 (1959)
DOI:10.1016/0006-3002(59)90504-9
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.20
IUBMB Enzyme Nomenclature: 1.3.1.20
ExPASy - ENZYME nomenclature database: 1.3.1.20
BRENDA, the Enzyme Database: 1.3.1.20
CAS: 37255-32-6

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