KEGG   ENZYME: 1.1.1.132Help
Entry
EC 1.1.1.132                Enzyme                                 

Name
GDP-mannose 6-dehydrogenase;
guanosine diphosphomannose dehydrogenase;
GDP-mannose dehydrogenase;
guanosine diphosphomannose dehydrogenase;
guanosine diphospho-D-mannose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
GDP-D-mannose:NAD+ 6-oxidoreductase
Reaction(IUBMB)
GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+ [RN:R00880]
Reaction(KEGG)
Substrate
GDP-D-mannose [CPD:C00096];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
GDP-D-mannuronate [CPD:C00976];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on the corresponding deoxynucleoside diphosphate derivative as a substrate.
History
EC 1.1.1.132 created 1972
Pathway
ec00051  Fructose and mannose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K00066  GDP-mannose 6-dehydrogenase
Genes
PAE: PA3540(algD)
PAEV: N297_3663(algD)
PAEI: N296_3663(algD)
PAU: PA14_18580(algD)
PAP: PSPA7_1605(algD)
PAG: PLES_14931(algD)
PAF: PAM18_1446(algD)
PNC: NCGM2_4665(algD)
PAEB: NCGM1900_2744(algD)
PDK: PADK2_06665
PAEP: PA1S_07720
PAEM: U769_07195
PAEL: T223_07435
PAEU: BN889_03910(algD)
PAEG: AI22_26185
PAEC: M802_3660(algD)
PAEO: M801_3528(algD)
PMK: MDS_1082
PRE: PCA10_11880(algD) PCA10_38230(algD)
PCQ: PcP3B5_50680(algD)
PPU: PP_1288(algD)
PPF: Pput_4437
PPT: PPS_4403
PPI: YSA_03091
PPX: T1E_3168(algD)
PPUH: B479_22150
PPUT: L483_27235
PPUN: PP4_08000(algD)
PPUD: DW66_4794
PMON: X969_21685
PMOT: X970_21320
PST: PSPTO_1243(algD)
PSB: Psyr_1063
PSYR: N018_20355
PSP: PSPPH_1118(algD)
PFL: PFL_1024(algD)
PPRC: PFLCHA0_c10440(algD)
PPRO: PPC_1062
PFO: Pfl01_0960(algD)
PFS: PFLU_0990(algD)
PFC: PflA506_0970(algD)
PFW: PF1751_v1c09480(algD)
PFB: VO64_4071
PMAN: OU5_2447
PEN: PSEEN3453(algD-2) PSEEN4535(algD)
PPUU: PputUW4_04471(algD)
PKC: PKB_0968(algD)
PSES: PSCI_0721
PSEM: TO66_05210
PSEC: CCOS191_0912(algD1) CCOS191_2029(algD2)
PSOS: POS17_1030
PANR: A7J50_0992
PSIL: PMA3_24585
AVN: Avin_10970(algD)
AVL: AvCA_10970(algD)
AVD: AvCA6_10970(algD)
ACX: Achr_31180(algD)
ABO: ABO_0384(algD)
TAU: Tola_1407
SVA: SVA_1550
PLG: NCTC10937_04283(algD)
RFR: Rfer_0673
JAG: GJA_3986(algD)
EBA: ebA4268(algD)
AZO: azo3269(algD)
AOA: dqs_3408
NIS: NIS_0191
DTO: TOL2_C36540(algD)
BMX: BMS_2990
BJA: blr6296
BRA: BRADO7047
BRS: S23_62720
MNO: Mnod_5882
BID: Bind_3885
MMED: Mame_02304(algD)
RBM: TEF_19885
DSH: Dshi_1896(algD)
MALG: MALG_02776
NAR: Saro_3220
SPHI: TS85_22025
SSAN: NX02_04640
CSC: Csac_2360
MSM: MSMEG_5957(algD)
MVA: Mvan_1699
ROP: ROP_57960(algD)
SCO: SCO0382(SCF62.08)
SBH: SBI_09543
SHY: SHJG_7006
SVE: SVEN_7199
SALU: DC74_1121
SALL: SAZ_06100
SLV: SLIV_36030(algD)
STRE: GZL_08291
SLD: T261_7968
SPRI: SPRI_2000
SNR: SNOUR_37270(algD)
STRD: NI25_00640
SALF: SMD44_08071(algD)
SFK: KY5_0166c
ACH: Achl_2940
NDK: I601_0111(algD)
SRO: Sros_0655
BSD: BLASA_0423(algD)
AMD: AMED_0547(algD)
AMN: RAM_02805
AMM: AMES_0545(algD)
AMZ: B737_0546(algD)
AOI: AORI_0554(algD)
AJA: AJAP_36870(algD)
AMQ: AMETH_0542(ugd)
PDX: Psed_1848
TER: Tery_2263
CTHE: Chro_0719
STI: Sthe_1134
SUS: Acid_0553
ZGA: ZOBELLIA_1984(algD)
CACI: CLOAM0663
NMV: NITMOv2_2630(algD)
 » show all
Taxonomy
Reference
1  [PMID:14245351]
  Authors
PREISS J.
  Title
SUGAR NUCLEOTIDE REACTIONS IN ARTHROBACTER. II. BIOSYNTHESIS OF GUANOSINE DIPHOSPHOMANNURONATE.
  Journal
J Biol Chem 239:3127-32 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.132
IUBMB Enzyme Nomenclature: 1.1.1.132
ExPASy - ENZYME nomenclature database: 1.1.1.132
BRENDA, the Enzyme Database: 1.1.1.132
CAS: 37250-63-8

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