KEGG   ENZYME: 1.1.1.14Help
Entry
EC 1.1.1.14                 Enzyme                                 

Name
L-iditol 2-dehydrogenase;
polyol dehydrogenase;
sorbitol dehydrogenase;
L-iditol:NAD+ 5-oxidoreductase;
L-iditol (sorbitol) dehydrogenase;
glucitol dehydrogenase;
L-iditol:NAD+ oxidoreductase;
NAD+-dependent sorbitol dehydrogenase;
NAD+-sorbitol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-iditol:NAD+ 2-oxidoreductase
Reaction(IUBMB)
L-iditol + NAD+ = L-sorbose + NADH + H+ [RN:R07145]
Reaction(KEGG)
R07145;
(other) R00875 R01896
Show
Substrate
L-iditol [CPD:C01507];
NAD+ [CPD:C00003]
Product
L-sorbose [CPD:C00247];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. Enzymes from different organisms or tissues display different substrate specificity. The enzyme is specific to NAD+ and can not use NADP+.
History
EC 1.1.1.14 created 1961, modified 2011
Pathway
ec00040  Pentose and glucuronate interconversions
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K00008  L-iditol 2-dehydrogenase
Genes
HSA: 6652(SORD)
PTR: 453394(SORD)
PPS: 100978081(SORD)
GGO: 101136473 101143696(SORD)
PON: 100173784(SORD)
NLE: 100594471 100594828(SORD)
MCC: 712784(SORD)
MCF: 101865740(SORD)
CSAB: 103221304 103245712(SORD)
RRO: 104653890(SORD)
RBB: 108530135(SORD)
CJC: 100405393(SORD)
SBQ: 101045586(SORD)
MMU: 20322(Sord)
RNO: 24788(Sord)
CGE: 100751427(Sord)
NGI: 103746886(Sord)
HGL: 101699735(Sord)
CCAN: 109692710(Sord)
OCU: 100355885(SORD)
TUP: 102498655(SORD)
CFA: 487535(SORD)
AML: 100469986(SORD)
UMR: 103656573(SORD)
ORO: 101384445(SORD)
FCA: 101088085(SORD)
PTG: 102953880(SORD)
AJU: 106968464(SORD)
BTA: 508954(SORD)
BOM: 102271539(SORD)
BIU: 109565169(SORD)
PHD: 102335046(SORD)
CHX: 102186213(SORD)
OAS: 101115280(SORD)
SSC: 100158181(SORD)
CFR: 102509205(SORD)
CDK: 105101694(SORD)
BACU: 103014698(SORD)
LVE: 103071699(SORD)
OOR: 101279594(SORD)
ECB: 100070575(SORD)
EPZ: 103554033(SORD)
EAI: 106834998(SORD)
MYB: 102253534(SORD)
MYD: 102753022(SORD)
HAI: 109396663(SORD)
RSS: 109444146(SORD)
PALE: 102895692(SORD)
LAV: 100653975(SORD)
TMU: 101356393
MDO: 100012620(SORD)
SHR: 100931000(SORD)
OAA: 100087927
GGA: 415332(SORD)
MGP: 100539102(SORD)
CJO: 107318482(SORD)
APLA: 101800431(SORD)
ACYG: 106047453(SORD)
TGU: 100226453(SORD)
GFR: 102037225(SORD)
FAB: 101816314(SORD)
PHI: 102104088(SORD)
PMAJ: 107209556(SORD)
CCW: 104697519(SORD)
FPG: 101914500(SORD)
FCH: 102054618(SORD)
CLV: 102097535(SORD)
EGZ: 104130688(SORD)
AAM: 106487986(SORD)
ASN: 102385752(SORD)
AMJ: 102573919(SORD)
PSS: 102461329(SORD)
CMY: 102933153(SORD)
CPIC: 101943040(SORD)
PVT: 110086859(SORD)
PBI: 103059309(SORD)
GJA: 107106717(SORD)
XLA: 108712961(sord.S) 446317(sord.L)
XTR: 496715(sord)
NPR: 108801819(SORD)
DRE: 570613(sord)
IPU: 100528674(sord)
TRU: 101065362(sord)
LCO: 104919242(sord)
NCC: 104958296(sord)
MZE: 101477328(sord)
OLA: 101165040(sord)
XMA: 102236422(sord)
PRET: 103462422(sord)
NFU: 107381455(sord)
CSEM: 103378759(sord)
LCF: 108889652(sord)
HCQ: 109514452(sord)
BPEC: 110172945(sord)
SASA: 100196489(dhso) 106562152
ELS: 105030774(sord)
SFM: 108926697(sord)
LCM: 102345933(SORD)
DME: Dmel_CG1982(Sodh-1) Dmel_CG4649(Sodh-2)
DSI: Dsimw501_GD18723(Dsim_GD18723) Dsimw501_GD19902(Dsim_GD19902)
MDE: 101887985
AME: 408871(GB14284)
BIM: 100746622
BTER: 100645107
SOC: 105207604
AEC: 105149652
ACEP: 105619020
PBAR: 105431443
HST: 105184238
CFO: 105248294
PGC: 109860549
DPA: 109534586
BMOR: 100529206(SDH2b) 101738079 692742(Sdh) 733025
API: 100159783
DNX: 107167379
ZNE: 110830894
FCD: 110842191
CEL: CELE_R04B5.5(R04B5.5) CELE_R04B5.6(R04B5.6)
CBR: CBG08605
BMY: Bm1_21410
OBI: 106878309
ADF: 107350482
HMG: 100215837
ATH: AT5G51970
CRB: 17874643
BRP: 103832662
THJ: 104811484
VRA: 106771505
VAR: 108344681
CCAJ: 109789245
CAM: 101503369
LJA: Lj0g3v0006049.1(Lj0g3v0006049.1) Lj2g3v0549950.1(Lj2g3v0549950.1) Lj2g3v0549960.1(Lj2g3v0549960.1)
LANG: 109325828
CMAX: 111482739
CMOS: 111430573
CPEP: 111810563
VVI: 100265888(L-IDH2)
SLY: 778312(SDH)
CANN: 107874232
SIND: 105160529
BVG: 104906418
OSA: 4346217
DOSA: Os08t0545200-01(Os08g0545200)
OBR: 102721014
BDI: 100834423
ATS: 109735899(LOC109735899)
SBI: 8057862
ZMA: 100283066(sdh1)
SITA: 101760873
MUS: 103983248
AOF: 109824704
ATR: 18447785
APRO: F751_6386
SCE: YDL246C(SOR2) YJR159W(SOR1)
PIC: PICST_40172(SOR3)
SLB: AWJ20_2758(SOR1) AWJ20_631(XYL2)
NTE: NEUTE1DRAFT121519(NEUTE1DRAFT_121519) NEUTE1DRAFT133717(NEUTE1DRAFT_133717) NEUTE1DRAFT93090(NEUTE1DRAFT_93090)
ANG: ANI_1_1350124(An14g03510) ANI_1_1366084(An09g03900) ANI_1_1474014(An01g10920) ANI_1_234144(An16g01710)
ABE: ARB_02064
TVE: TRV_06442
ABP: AGABI1DRAFT112007(AGABI1DRAFT_112007) AGABI1DRAFT115279(AGABI1DRAFT_115279)
ABV: AGABI2DRAFT193249(AGABI2DRAFT_193249) AGABI2DRAFT194241(AGABI2DRAFT_194241)
SMIN: v1.2.038457.t1(symbB.v1.2.038457.t1)
NGD: NGA_0523801(GUTB) NGA_0523802(GUTB)
ECF: ECH74115_2498(gutB)
SENS: Q786_21240
SED: SeD_A2059(gutB)
KOX: KOX_14445
KOE: A225_1715
YPE: YPO2502(gutB)
YPK: y1686
YPA: YPA_1997
YPN: YPN_2096
YPM: YP_2317(gutB)
YPZ: YPZ3_2144
YPD: YPD4_2187(gutB)
YPX: YPD8_2199(gutB)
YPH: YPC_1623(gutB)
YPW: CH59_39
YPJ: CH55_108
YPV: BZ15_1031
YPL: CH46_2611
YPS: YPTB2538(gutB)
YPO: BZ17_4099
YPY: YPK_1610
YPB: YPTS_2633
YPQ: DJ40_4004
YPU: BZ21_1835
YPR: BZ20_3670
YPC: BZ23_2119
YPF: BZ19_1901
SMAR: SM39_2764
SERF: L085_12180
PAJ: PAJ_3713(tdh)
PVA: Pvag_pPag20221(gutB)
PFS: PFLU_3993
PFW: PF1751_v1c34560(gutB)
PFB: VO64_1078
PANR: A7J50_3655
HCH: HCH_02471
BMA: BMA1195
BMAL: DM55_2965
BMAE: DM78_1431
BMAQ: DM76_2947
BMAI: DM57_30
BMAF: DM51_922
BMAZ: BM44_2214
BMAB: BM45_1778
BPS: BPSL1790
BPM: BURPS1710b_2072(gutB)
BPSE: BDL_315
BPSM: BBQ_1651
BPSU: BBN_1777
BPSD: BBX_2254
BPK: BBK_3278
BPSH: DR55_2889
BPSA: BBU_489
BPSO: X996_2506
BUT: X994_960
BTE: BTH_I2432
BTJ: BTJ_868
BTZ: BTL_2111
BTD: BTI_2073
BTV: BTHA_2310
BTHE: BTN_2657
BTHM: BTRA_2390
BTHA: DR62_2804
BTHL: BG87_2332
BOK: DM82_1254
BOC: BG90_3436
BCN: Bcen_3550
BCJ: BCAM2015
BCEN: DM39_5798
BCEW: DM40_4784
BCEO: I35_5851
BAM: Bamb_4198
BMU: Bmul_3786
BMK: DM80_5170
BMUL: NP80_4759
BCED: DM42_5986
BDL: AK34_3678
BCON: NL30_02200
BLAT: WK25_26400
BTEI: WS51_07425
BSEM: WJ12_30165
BPSL: WS57_04130
BMEC: WJ16_28700
BPH: Bphy_0503
BFN: OI25_2183
POL: Bpro_1286
VEI: Veis_2683
DAC: Daci_4579
OFO: BRW83_1074(gatD)
PCA: Pcar_2180
DAL: Dalk_2577
BMX: BMS_3105
MES: Meso_3701
SME: SM_b20853
EAD: OV14_b1215(tdh)
RLE: RL0651
RHT: NT26_0353
RDE: RD1_0514(gutB) RD1_3810(gutB)
OTM: OSB_08150(tdh)
MALG: MALG_04571
SPHD: HY78_18085
AMV: ACMV_17030(gutB)
MAGQ: MGMAQ_3287
BSU: BSU06150(gutB)
BSR: I33_0702
BSL: A7A1_0005
BSH: BSU6051_06150(gutB)
BSUT: BSUB_00682(gutB)
BSUL: BSUA_00682(gutB)
BSUS: Q433_03475
BSS: BSUW23_03100(gutB)
BST: GYO_0871
BSO: BSNT_06981(gutB)
BSQ: B657_06150(gutB)
BSX: C663_0633(gutB)
BAY: RBAM_006540(gutB)
BAQ: BACAU_0625(gutB)
BYA: BANAU_0565(gutB)
BAMP: B938_02990
BAML: BAM5036_0574(gutB)
BAMA: RBAU_0631(gutB)
BAMN: BASU_0602(gutB)
BAMB: BAPNAU_0573(gutB)
BAMT: AJ82_03635
BAMY: V529_05790(gutB)
BMP: NG74_00634(gutB_2)
BAO: BAMF_0606(gutB3)
BAZ: BAMTA208_02825(gutB3)
BQL: LL3_00649(gutB)
BXH: BAXH7_00593(gutB2)
BQY: MUS_0619(gutB)
BAMI: KSO_016500
BAMC: U471_06250
BAMF: U722_03240
BATR: TD68_00225
BHA: BH0187(gutB) BH0189
BPU: BPUM_1170
BPUM: BW16_06665
BPUS: UP12_06210
BMD: BMD_3588(gutB)
BAG: Bcoa_0599
BJS: MY9_0685
BACW: QR42_06065
BACP: SB24_06605
BACB: OY17_05880
BACY: QF06_01985
BACL: BS34A_07070(gutB)
BALM: BsLM_0641
BEO: BEH_00910
GTN: GTNG_1950
ANM: GFC28_380(gutB)
ANL: GFC29_1244(gutB)
SAC: SACOL0233(gutB) SACOL0235
SAD: SAAV_0215
SAUR: SABB_01603 SABB_01604(gutB)
SHA: SH0215(gutB)
SSP: SSP0366
LMOG: BN389_05440(gatD) BN389_26290(gutB) BN389_26300(gatD_2)
LMQ: LMM7_0528(gatD-1) LMM7_2775(ydjL) LMM7_2776(gatD-2)
PPOL: X809_29035
PMS: KNP414_02055(gutB) KNP414_02088(gutB2)
PSAB: PSAB_18810
PRI: PRIO_0917(ydjJ)
AAC: Aaci_2330
AAD: TC41_2611(gutB)
LPL: lp_3545
LPJ: JDM1_2831(gutB)
LPT: zj316_0159(gutB)
LPS: LPST_C2895(gutB)
LPZ: Lp16_2771
CPF: CPF_0732
CBO: CBO3418
CBA: CLB_3475
CBH: CLC_3363
CBY: CLM_3884
CBL: CLK_2861
CBK: CLL_A3334
CBB: CLD_1088
CBI: CLJ_B3725
CBT: CLH_2693
CBF: CLI_3601
CBM: CBF_3584
AMT: Amet_0590
CCEL: CCDG5_0069(ydjJ1) CCDG5_0658(ydjJ3)
FPR: FP2_13950
BFI: CIY_06310
RIM: ROI_38250
ERT: EUR_10430
ERA: ERE_17310
CST: CLOST_0774(ydjJ)
PTH: PTH_0271(Tdh)
EHL: EHLA_1394
AWO: Awo_c01070(gatD)
TMR: Tmar_0397
CHY: CHY_1307(gutB)
VRM: 44547418_00080(gutB)
MHG: MHY_15350
MMC: Mmcs_2786
MKM: Mkms_2830
MJL: Mjls_2813
MVA: Mvan_5590
MGI: Mflv_1218
MPHL: MPHLCCUG_00885(gutB_1) MPHLCCUG_01560(gutB_2)
ASD: AS9A_4399
RER: RER_36890
REY: O5Y_16970
ROP: ROP_25050
RFA: A3L23_01342(gutB_2) A3L23_01444(gutB_3) A3L23_03385(gutB_4)
RHS: A3Q41_01913(gutB_1) A3Q41_02016(gutB_2)
RHU: A3Q40_03970(gutB_2)
SALU: DC74_6637
SALL: SAZ_34505
SLD: T261_1406
SRW: TUE45_01341(gutB_2)
SFK: KY5_6962
AAU: AAur_2421
ACH: Achl_1714
BCV: Bcav_4187
LMOI: VV02_13605
BLIN: BLSMQ_3196
PAC: PPA0918
PAW: PAZ_c09550(gutB1)
PACC: PAC1_04850
PACH: PAGK_1234
NDK: I601_4066(tdh_2)
PSIM: KR76_07765
NDA: Ndas_4221
NML: Namu_3324
GOB: Gobs_2793
KRA: Krad_1455
AMQ: AMETH_0710(tdh) AMETH_6418(adh)
PSEA: WY02_19540
PSEH: XF36_12745
ASE: ACPL_6369
AFS: AFR_23415
ACTS: ACWT_6236
CWO: Cwoe_5082
GLJ: GKIL_0043(gutB) GKIL_3538(gutB)
NSP: BMF81_02162(gutB)
DET: DET0125
DEH: cbdbA145
DMC: btf_84
DFO: Dform_00570(gutB)
DGE: Dgeo_2864
AGL: PYTT_0195
RBA: RB3488 RB5948(adh)
FMR: Fuma_02785(gutB)
TTF: THTE_3976
KST: KSMBR1_0625(gutB)
PBAS: SMSP2_01033(gutB)
VBL: L21SP4_00937(gutB_1)
TDE: TDE0075
BPW: WESB_1402
ACA: ACP_0816
ABAC: LuPra_03105 LuPra_04641(tdh_2)
BXY: BXY_35590
PDI: BDI_1350
DORI: FH5T_18265
CPI: Cpin_5213
FAE: FAES_5073
TNP: Tnap_0936
DTU: Dtur_0389
MHI: Mhar_1252
HMA: pNG7032(adh10)
HHI: HAH_5138(qor2)
HUT: Huta_2013
HTI: HTIA_1662
HME: HFX_6255(adh10)
HTU: Htur_0827
SALI: L593_14285
SSO: SSO3237
SOL: Ssol_0970
SSOA: SULA_1003
SSOL: SULB_1005
SSOF: SULC_1004
STO: STK_23410
SAI: Saci_0410
SID: M164_2134
SII: LD85_2397
SIH: SiH_2076
SIR: SiRe_2009
SIC: SiL_1983
MSE: Msed_0196
MCN: Mcup_1877
AHO: Ahos_1067
NMR: Nmar_1079
NCT: NMSP_0168(tdh_1) NMSP_0542(tdh_2)
NEV: NTE_02181
TAA: NMY3_02388(gutB)
NCV: NCAV_1108
NBV: T478_0891
NDV: NDEV_1168
BARC: AOA65_0802(tdh_2) AOA65_0803(tdh_3) AOA65_1855(tdh_6) AOA65_2211(tdh_7)
 » show all
Taxonomy
Reference
1
  Authors
Bailey, J.P., Renz, C. and McGuinness, E.T.
  Title
Sorbitol dehydrogenase from horse liver: purification, characterization and comparative properties.
  Journal
Comp Biochem Physiol 69B:909-914 (1981)
Reference
2  [PMID:6852349]
  Authors
Burnell JN, Holmes RS.
  Title
Purification and properties of sorbitol dehydrogenase from mouse liver.
  Journal
Int J Biochem 15:507-11 (1983)
Reference
3  [PMID:667078]
  Authors
Leissing N, McGuinness ET.
  Title
Rapid affinity purification and properties of rat liver sorbitol dehydrogenase.
  Journal
Biochim Biophys Acta 524:254-61 (1978)
DOI:10.1016/0005-2744(78)90162-6
Reference
4  [PMID:16660917]
  Authors
Negm FB, Loescher WH.
  Title
Detection and Characterization of Sorbitol Dehydrogenase from Apple Callus Tissue.
  Journal
Plant Physiol 64:69-73 (1979)
Reference
5  [PMID:6870831]
  Authors
O'Brien MM, Schofield PJ, Edwards MR.
  Title
Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase.
  Journal
Biochem J 211:81-90 (1983)
Reference
6  [PMID:1460002]
  Authors
Ng K, Ye R, Wu XC, Wong SL
  Title
Sorbitol dehydrogenase from Bacillus subtilis. Purification, characterization, and gene cloning.
  Journal
J Biol Chem 267:24989-94 (1992)
  Sequence
[bsu:BSU06150]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.14
IUBMB Enzyme Nomenclature: 1.1.1.14
ExPASy - ENZYME nomenclature database: 1.1.1.14
BRENDA, the Enzyme Database: 1.1.1.14
CAS: 9028-21-1

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