KEGG   ENZYME: 1.1.1.140Help
Entry
EC 1.1.1.140                Enzyme                                 

Name
sorbitol-6-phosphate 2-dehydrogenase;
ketosephosphate reductase;
ketosephosphate reductase;
D-sorbitol 6-phosphate dehydrogenase;
D-sorbitol-6-phosphate dehydrogenase;
sorbitol-6-P-dehydrogenase;
D-glucitol-6-phosphate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase
Reaction(IUBMB)
D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+ [RN:R07133]
Reaction(KEGG)
Substrate
D-sorbitol 6-phosphate [CPD:C01096];
NAD+ [CPD:C00003]
Product
D-fructose 6-phosphate [CPD:C00085];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.1.1.140 created 1972
Pathway
ec00051  Fructose and mannose metabolism
Orthology
K00068  sorbitol-6-phosphate 2-dehydrogenase
Genes
ECO: b2705(srlD)
ECJ: JW2674(srlD)
ECD: ECDH10B_2873(srlD)
EBW: BWG_2441(srlD)
ECOK: ECMDS42_2210(srlD)
ECE: Z4012(srlD) Z5618
ECS: ECs3561 ECs5003
ECF: ECH74115_3955(srlD) ECH74115_5498
ETW: ECSP_3653(srlD) ECSP_5096
ELX: CDCO157_3321 CDCO157_4686
EOH: ECO103_3240(srlD)
EOK: G2583_3353(srlD) G2583_4845(sorD)
ESO: O3O_19595
ESM: O3M_06095
ESL: O3K_06050
ECW: EcE24377A_2989(srlD)
ELH: ETEC_2896
ECC: c3259(srlD) c4986
ECX: EcHS_A2841(srlD)
ECY: ECSE_2953
ECR: ECIAI1_2797(srlD)
ECK: EC55989_2967(srlD)
EOC: CE10_3128(srlD) CE10_4709
ELO: EC042_2898(srlD) EC042_4389(sorD)
EBR: ECB_02555(srlD)
EBD: ECBD_1020
EKF: KO11_09495(srlD)
EDJ: ECDH1ME8569_2615(srlD)
EIH: ECOK1_3077(srlD) ECOK1_4505(sorD)
ELW: ECW_m2904(srlD)
ELL: WFL_14170(srlD)
ELC: i14_2990(srlD) i14_4575
ELD: i02_2990(srlD) i02_4575
ELP: P12B_c2806(srlD)
EBL: ECD_02555(srlD)
EBE: B21_02520(srlD)
ELF: LF82_2172(srlD) LF82_637
ECOI: ECOPMV1_02961(srlD) ECOPMV1_04400(fabG_4)
ECOS: EC958_2971(srlD) EC958_4475
EFE: EFER_4082
STY: STY2956(gutD)
STT: t2736(srlD)
STM: STM2835(srlD)
SEO: STM14_3425(srlD)
SEY: SL1344_2815(gutD)
SEJ: STMUK_2824(srlD)
SEB: STM474_2973(srlD)
SEF: UMN798_3079(gutD)
SENR: STMDT2_27361(gutD)
SEND: DT104_28321(gutD)
SENI: CY43_14815
SPT: SPA2693(srlD)
SEK: SSPA2507
SEI: SPC_2876(srlD)
SEC: SCH_2768(srlD)
SEH: SeHA_C3021(srlD)
SHB: SU5_03316
SEE: SNSL254_A3037(srlD)
SEW: SeSA_A2986(srlD)
SEA: SeAg_B2955(srlD)
SENS: Q786_13635
SED: SeD_A3144(srlD)
SEG: SG2738(srlD)
SEL: SPUL_2829(srlD)
SEGA: SPUCDC_2815(srlD)
SET: SEN2676(srlD)
SENA: AU38_13595
SENO: AU37_13605
SENV: AU39_13605
SENQ: AU40_15330
SENL: IY59_14190
SEEP: I137_13485
SENB: BN855_28720(srlD)
SENE: IA1_13550
SBG: SBG_2455(srlD)
SBZ: A464_2855
SFL: SF2728(srlD) SF4093(sorD)
SFX: S2919(srlD) S3637(sorD)
SFV: SFV_2800(srlD) SFV_4098(sorD)
SFE: SFxv_2992(srlD) SFxv_4463
SFT: NCTC1_03003(srlD) NCTC1_04449(fabG_5)
SSN: SSON_4198(sorD)
SBO: SBO_2813(srlD) SBO_4048(sorD)
SDY: SDY_2902(srlD)
ENC: ECL_04042
EEC: EcWSU1_03520(srlD)
ECLX: LI66_17600
ECLY: LI62_19080
KPN: KPN_03040(srlD) KPN_04407
KPU: KP1_4304(srlD)
KPP: A79E_1057
KPE: KPK_1086(srlD) KPK_5267(sorD)
KPR: KPR_0390(sorD) KPR_1250(srlD)
KPX: PMK1_00517(srlD)
KPNK: BN49_1088(srlD) BN49_5026(sorD)
EAE: EAE_01570
EAR: CCG33680
CKO: CKO_04059
CRO: ROD_31091(srlD)
EBF: D782_4246
YEN: YE1095(gutD)
YEY: Y11_43201
YEW: CH47_511(srlD)
YET: CH48_513(srlD)
YEE: YE5303_08481(gutD)
YAL: AT01_3566(srlD)
YFR: AW19_15 AW19_285(srlD)
YIN: CH53_610(srlD)
YRO: CH64_1444(srlD)
SPE: Spro_3572
SRL: SOD_c34940(srlD)
SMW: SMWW4_v1c36840(srlD)
SMAR: SM39_3178(srlD)
SMAC: SMDB11_2967(srlD)
SERF: L085_10215
RAA: Q7S_18745
EPY: EpC_05810(srlD)
EPR: EPYR_00605(srlD)
EAM: EAMY_3073(srlD)
EAY: EAM_0524(srlD)
EBI: EbC_25910(srlD)
ERJ: EJP617_05210(srlD)
PAM: PANA_0835(srlD)
PLF: PANA5342_3471(srlD)
PVA: Pvag_pPag20075(srlD1) Pvag_pPag20100(srlD3)
HSO: HS_0676(srlD)
HSM: HSM_1085
PMU: PM1968
PMV: PMCN06_1355(srlD)
PMP: Pmu_13760(srlD)
PMUL: DR93_2131(srlD)
MHT: D648_1200
MHAT: B824_420
MHX: MHH_c06560(srlD)
MHAE: F382_07545
MHAM: J450_07495
MHAO: J451_08425
MHAL: N220_00530
MHAQ: WC39_13535
MHAY: VK67_13540
MVR: X781_580
ASU: Asuc_0437
BTO: WQG_7750
BTRE: F542_14300
BTRH: F543_15950
BTRA: F544_8100
VAN: VAA_01031
VAU: VANGNB10_cII0288(srlD)
ASA: ASA_3580(srlD)
CVI: CV_2258
BLI: BL02488
BLD: BLi03863
BCL: ABC1160
BGY: BGLY_4269
VPN: A21D_00490(polS)
SCA: SCA_2317(srlD)
GMO: NCTC11323_01509(polS)
LPK: LACPI_0323(srlD)
SMU: SMU_308
SMJ: SMULJ23_1660(sorD)
SMUA: SMUFR_0260(srlD)
SEZ: Sez_0204(sorD)
SEQ: SZO_01750(sorD)
SEQU: Q426_08255
SUB: SUB1705(sorD)
STK: STP_1528 STP_1724(sorD)
LPL: lp_3623(srlD1) lp_3657(srlD2)
LPJ: JDM1_2925(srlD2)
LPT: zj316_0196(srlD2)
LPS: LPST_C2987(srlD2)
LPZ: Lp16_2811
LSL: LSL_1894
LSI: HN6_01641
LSJ: LSJ_2142c
LCA: LSEI_2729
LPAP: LBPC_2682
LCB: LCABL_04240(sorF) LCABL_29060(gutF)
LCS: LCBD_0414(fabG) LCBD_0427 LCBD_2935(dhs-11)
LCW: BN194_04190(sorD) BN194_04320(sorD_2) BN194_28500(sorD_3)
LRH: LGG_00342(srlD) LGG_02722(sorD)
LRL: LC705_00407(sorF) LC705_02725(sorD)
LKE: WANG_1606
EFA: EF3310
EFL: EF62_0369(gutF)
EFS: EFS1_2710(sorD)
EFN: DENG_03201(srlD)
EFQ: DR75_2018
ENE: ENT_00310
EFU: HMPREF0351_11533(sorD)
EFM: M7W_2013
EMU: EMQU_1859
CRN: CAR_c14460(sorD)
CBO: CBO3413(gutD)
CBA: CLB_3470(srlD)
CBH: CLC_3358(srlD)
CBY: CLM_3879(srlD)
CBL: CLK_2856(srlD)
CBK: CLL_A0401
CBB: CLD_1093(srlD)
CBI: CLJ_B3720(srlD)
CBT: CLH_0387
CBF: CLI_3596(srlD)
CBM: CBF_3579(srlD)
CBE: Cbei_0340
CBZ: Cbs_0340
CBEI: LF65_00375
CPAT: CLPA_c28790(sorD1) CLPA_c29010(sorD2)
CPAE: CPAST_c28790(sorD1) CPAST_c29010(sorD2)
CLD: CLSPO_c35750(srlD)
CSS: Cst_c08660(srlD)
CSD: Clst_0831(adh4)
CDF: CD630_07680(srlD)
PDC: CDIF630_00886(srlD)
CDC: CD196_0715(gutD)
CDL: CDR20291_0696(gutD)
PDF: CD630DERM_07680(srlD)
EHL: EHLA_1883
CSC: Csac_0868
ATE: Athe_0698
MHG: MHY_15650
PUF: UFO1_3501
PFT: JBW_01379
MMY: MSC_0020(srlD)
MMYM: MMS_A0020(srlD)
MML: MLC_0190(srlD)
MCP: MCAP_0029
MCAC: MCCP01_0033(srlD)
MCAP: MCCPF38_00033(srlD)
MCAR: MCCPILRI181_00031(srlD)
MCAI: MCCG_0031
MLC: MSB_A0035(srlD)
SLL: SLITO_v1c06730(srlD)
SHJ: SHELI_v1c09280(srlD)
ACIJ: JS278_01318(srlD)
VBL: L21SP4_01285(srlD)
DTU: Dtur_0422
 » show all
Taxonomy
Reference
1  [PMID:4318899]
  Authors
Du Toit PJ, Kotze JP.
  Title
The isolation and characterization of sorbitol-6-phosphate dehydrogenase from Clostridium pasteurianum.
  Journal
Biochim Biophys Acta 206:333-42 (1970)
DOI:10.1016/0005-2744(70)90150-6
Reference
2  [PMID:14465816]
  Authors
LISS M, HORWITZ SB, KAPLAN NO.
  Title
D-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase in Aerobacter aerogenes.
  Journal
J Biol Chem 237:1342-50 (1962)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.140
IUBMB Enzyme Nomenclature: 1.1.1.140
ExPASy - ENZYME nomenclature database: 1.1.1.140
BRENDA, the Enzyme Database: 1.1.1.140
CAS: 37250-69-4

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