KEGG   ENZYME: 1.1.1.146Help
Entry
EC 1.1.1.146                Enzyme                                 

Name
11beta-hydroxysteroid dehydrogenase;
corticosteroid 11beta-dehydrogenase;
beta-hydroxysteroid dehydrogenase;
11beta-hydroxy steroid dehydrogenase;
corticosteroid 11-reductase;
dehydrogenase, 11beta-hydroxy steroid
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
11beta-hydroxysteroid:NADP+ 11-oxidoreductase
Reaction(IUBMB)
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ [RN:R03203]
Reaction(KEGG)
Substrate
11beta-hydroxysteroid [CPD:C01058];
NADP+ [CPD:C00006]
Product
11-oxosteroid [CPD:C01985];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.146 created 1972
Pathway
ec00140  Steroid hormone biosynthesis
ec00980  Metabolism of xenobiotics by cytochrome P450
ec01100  Metabolic pathways
Orthology
K15680  corticosteroid 11-beta-dehydrogenase isozyme 1
K22418  11beta/17beta-hydroxysteroid dehydrogenase
Genes
HSA: 3290(HSD11B1)
PTR: 457698(HSD11B1)
PPS: 100981291(HSD11B1)
GGO: 101147766(HSD11B1)
PON: 100453076(HSD11B1)
NLE: 100593811(HSD11B1)
MCC: 574322(HSD11B1)
MCF: 101867467(HSD11B1)
CSAB: 103230154(HSD11B1)
RRO: 104664165(HSD11B1)
RBB: 108539553(HSD11B1)
CJC: 100401212(HSD11B1)
SBQ: 101040472(HSD11B1)
MMU: 15483(Hsd11b1)
RNO: 25116(Hsd11b1)
CGE: 100762502(Hsd11b1)
NGI: 103727028(Hsd11b1)
HGL: 101716800(Hsd11b1)
CCAN: 109681612(Hsd11b1)
OCU: 100342395(HSD11B1)
TUP: 102502602(HSD11B1)
CFA: 449023(HSD11B1)
AML: 100466840(HSD11B1)
UMR: 103672488(HSD11B1)
ORO: 101369340(HSD11B1)
FCA: 100529248(HSD11B1)
PTG: 102967279(HSD11B1)
AJU: 106981789(HSD11B1)
BTA: 282589(HSD11B1)
BOM: 102275244(HSD11B1)
BIU: 109570467(HSD11B1)
PHD: 102317655(HSD11B1)
CHX: 102168375(HSD11B1)
OAS: 443409(HSD11B1)
SSC: 397480(HSD11B1)
CFR: 102503994(HSD11B1)
CDK: 105099329(HSD11B1)
BACU: 103004239(HSD11B1)
LVE: 103086619(HSD11B1)
OOR: 101284098(HSD11B1)
ECB: 100056429(HSD11B1)
EPZ: 103548673(HSD11B1)
EAI: 106827175(HSD11B1)
MYB: 102260050(HSD11B1)
MYD: 102771648(HSD11B1)
RSS: 109436139(HSD11B1)
PALE: 102882377(HSD11B1)
LAV: 100667019(HSD11B1)
TMU: 101361858
SHR: 100923255(HSD11B1)
OAA: 100079059(HSD11B1)
GGA: 419861(HSD11B1b) 771930(HSD11B1a)
MGP: 100550364(HSD11B1) 100550517
PMAJ: 107214842 107214843(HSD11B1)
CCAE: 111922428 111939805(HSD11B1)
CLV: 102086357(HSD11B1) 102090135
AMJ: 102559578 102568341(HSD11B1)
ACS: 100555338(hsd11b1) 100555943
PVT: 110072366(HSD11B1) 110081926
PBI: 103052790 103059600(HSD11B1)
GJA: 107126071(HSD11B1) 107126084
XLA: 108709376(hsd11b1.S) 379494(hsd11b1l.2.L) 379497(hsd11b1.L) 399012(hsd11b1l.L)
XTR: 100038278(hsd11b1l.2) 100489345(hsd11b1)
NPR: 108789677(HSD11B1) 108800094
DRE: 100333777(hsd11b1lb)
SRX: 107750927
CCAR: 109048452
LCM: 102345616(HSD11B1)
CMK: 103182506(hsd11b1)
SPU: 764876
CRG: 105339932
OBI: 106874424
EPA: 110252440
ADF: 107340777
AQU: 100631443
ATH: AT5G50600(HSD1) AT5G50700(HSD1)
LJA: Lj4g3v2883360.1(Lj4g3v2883360.1) Lj4g3v2883370.1(Lj4g3v2883370.1) Lj4g3v2894400.1(Lj4g3v2894400.1)
DOSA: Os02t0511100-00(Os02g0511100) Os02t0511400-01(Os02g0511400) Os04t0390700-01(Os04g0390700) Os04t0390800-01(Os04g0390800) Os11t0499600-01(Os11g0499600) Os12t0464400-01(Os12g0464400)
ATS: 109747869(LOC109747869) 109752621(LOC109752621) 109752622(LOC109752622) 109764613(LOC109764613)
ABV: AGABI2DRAFT229948(AGABI2DRAFT_229948)
 » show all
Taxonomy
Reference
1  [PMID:2808402]
  Authors
Agarwal AK, Monder C, Eckstein B, White PC.
  Title
Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase.
  Journal
J Biol Chem 264:18939-43 (1989)
  Sequence
[rno:25116]
Reference
2  [PMID:4384445]
  Authors
Bush IE, Hunter SA, Meigs RA.
  Title
Metabolism of 11-oxygenated steroids. Metabolism in vitro by preparations of liver.
  Journal
Biochem J 107:239-58 (1968)
Reference
3  [PMID:3139396]
  Authors
Lakshmi V, Monder C.
  Title
Purification and characterization of the corticosteroid 11 beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid dehydrogenase complex.
  Journal
Endocrinology 123:2390-8 (1988)
DOI:10.1210/endo-123-5-2390
Reference
4  [PMID:2661206]
  Authors
Phillips DM, Lakshmi V, Monder C.
  Title
Corticosteroid 11 beta-dehydrogenase in rat testis.
  Journal
Endocrinology 125:209-16 (1989)
DOI:10.1210/endo-125-1-209
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.146
IUBMB Enzyme Nomenclature: 1.1.1.146
ExPASy - ENZYME nomenclature database: 1.1.1.146
BRENDA, the Enzyme Database: 1.1.1.146
CAS: 9041-46-7

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