KEGG   ENZYME: 1.1.1.168Help
Entry
EC 1.1.1.168                Enzyme                                 

Name
2-dehydropantolactone reductase (Re-specific);
2-oxopantoyl lactone reductase;
ketopantoyl lactone reductase;
2-ketopantoyl lactone reductase;
2-dehydropantoyl-lactone reductase (A-specific);
(R)-pantolactone:NADP+ oxidoreductase (A-specific);
2-dehydropantolactone reductase (A-specific)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-pantolactone:NADP+ oxidoreductase (Re-specific)
Reaction(IUBMB)
(R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+ [RN:R03155]
Reaction(KEGG)
Substrate
(R)-pantolactone [CPD:C01012];
NADP+ [CPD:C00006]
Product
2-dehydropantolactone [CPD:C01125];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The yeast enzyme differs from that from Escherichia coli [EC 1.1.1.214 2-dehydropantolactone reductase (Si-specific)], which is specific for the Si-face of NADP+, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase.
History
EC 1.1.1.168 created 1976, modified 1986, modified 1999
Reference
1  [PMID:4603075]
  Authors
King HL Jr, Dyar RE, Wilken DR.
  Title
Ketopantoyl lactone and ketopantoic acid reductases. Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase.
  Journal
J Biol Chem 249:4689-95 (1974)
Reference
2  [PMID:234966]
  Authors
Wilken DR, King HL Jr, Dyar RE.
  Title
Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate.
  Journal
J Biol Chem 250:2311-4 (1975)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.168
IUBMB Enzyme Nomenclature: 1.1.1.168
ExPASy - ENZYME nomenclature database: 1.1.1.168
BRENDA, the Enzyme Database: 1.1.1.168
CAS: 37211-75-9

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