KEGG   ENZYME: 1.1.1.170Help
Entry
EC 1.1.1.170                Enzyme                                 

Name
3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating);
3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating);
3beta-hydroxy-4beta-methylcholestenoate dehydrogenase;
sterol 4alpha-carboxylic decarboxylase;
sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (ambiguous);
ERG26 (gene name);
NSDHL (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3beta-hydroxysteroid-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
Reaction(IUBMB)
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+ = a 3-oxosteroid + CO2 + NAD(P)H [RN:R04483 R07149]
Reaction(KEGG)
Substrate
3beta-hydroxysteroid-4alpha-carboxylate;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
CO2 [CPD:C00011];
NADH [CPD:C00004];
NADPH [CPD:C00005]
Comment
The enzyme catalyses the decarboxylation of the C-4 carbon and the dehydrogenation of a 3beta hydroxyl at the C-3 carbon of 3beta-hydroxysteroid-4alpha-carboxylates. It is involved in zymosterol and cholesterol biosynthesis.
History
EC 1.1.1.170 created 1978, modified 2002, modified 2012
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K07748  sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
Genes
HSA: 50814(NSDHL)
PTR: 465960(NSDHL)
PPS: 100975917(NSDHL)
GGO: 101144867(NSDHL)
PON: 100172372(NSDHL)
NLE: 100596441(NSDHL)
MCC: 693333(NSDHL)
MCF: 102137627(NSDHL)
CSAB: 103232767(NSDHL)
RRO: 104654022(NSDHL)
RBB: 108513868(NSDHL)
CJC: 100398582(NSDHL)
SBQ: 101027738(NSDHL)
MMU: 18194(Nsdhl)
RNO: 309262(Nsdhl)
CGE: 100764429(Nsdhl) 100768776
NGI: 103731179(Nsdhl)
HGL: 101716507(Nsdhl)
CCAN: 109695438(Nsdhl)
OCU: 100351296(NSDHL)
TUP: 102500582(NSDHL)
CFA: 481079(NSDHL)
AML: 100466780(NSDHL)
UMR: 103674163(NSDHL)
ORO: 101372464(NSDHL)
FCA: 101096551(NSDHL)
PTG: 102959228(NSDHL)
AJU: 106971243(NSDHL)
BTA: 616694(NSDHL)
BOM: 102276234(NSDHL)
BIU: 109555394(NSDHL)
PHD: 102328837(NSDHL)
CHX: 102173170(NSDHL)
OAS: 101112792(NSDHL)
SSC: 100157894(NSDHL)
CFR: 102516550(NSDHL)
CDK: 105104051(NSDHL)
BACU: 103020703(NSDHL)
LVE: 103087463(NSDHL)
OOR: 101278134(NSDHL)
ECB: 100063648(NSDHL)
EPZ: 103543383(NSDHL)
EAI: 106834275(NSDHL)
MYB: 102257708(NSDHL)
MYD: 102771848(NSDHL)
HAI: 109394344(NSDHL)
RSS: 109434385(NSDHL) 109441062
PALE: 102879960(NSDHL)
LAV: 100671133(NSDHL)
TMU: 101357526
MDO: 100026414(NSDHL)
SHR: 100914940(NSDHL)
OAA: 103171093(NSDHL)
GGA: 422302(NSDHL)
MGP: 100544971(NSDHL)
CJO: 107312870(NSDHL)
APLA: 101790127(NSDHL)
ACYG: 106047509(NSDHL)
TGU: 100190543(NSDHL)
GFR: 102041531(NSDHL)
FAB: 101814664(NSDHL)
PHI: 102100867(NSDHL)
PMAJ: 107204042(NSDHL)
CCAE: 111929260(NSDHL)
CCW: 104691595(NSDHL)
FPG: 101921503(NSDHL)
FCH: 102048326(NSDHL)
CLV: 102098029(NSDHL)
EGZ: 104127975(NSDHL)
AAM: 106489838(NSDHL)
ASN: 102383140(NSDHL)
AMJ: 102562140(NSDHL)
PSS: 102447619(NSDHL)
CMY: 102945577(NSDHL)
CPIC: 101937255(NSDHL)
ACS: 100562829(nsdhl)
PVT: 110088403(NSDHL)
PBI: 103061373(NSDHL)
GJA: 107118212(NSDHL)
XLA: 108700163(nsdhl.S) 496236(nsdhl.L)
XTR: 550044(nsdhl)
NPR: 108795343(NSDHL)
DRE: 550369(nsdhl)
SRX: 107733445(nsdhl)
SANH: 107663101(nsdhl)
SGH: 107554660(nsdhl)
IPU: 108268902(nsdhl)
AMEX: 103027604(nsdhl)
TRU: 101061359(nsdhl)
LCO: 104923201(nsdhl) 109138051
NCC: 104948435(nsdhl)
MZE: 101480912(nsdhl)
OLA: 101171010(nsdhl)
XMA: 102221009(nsdhl)
PRET: 103471168(nsdhl)
NFU: 107395696(nsdhl)
KMR: 108242032(nsdhl)
CSEM: 103391149(nsdhl)
LCF: 108882885(nsdhl)
SDU: 111226496(nsdhl)
HCQ: 109515829(nsdhl)
BPEC: 110163595(nsdhl)
MALB: 109968402(nsdhl)
ELS: 105025751(nsdhl)
SFM: 108925361(nsdhl)
LCM: 102355835(NSDHL)
CMK: 103177331(nsdhl)
SPU: 577670
APLC: 110983741
SKO: 100367277
LAK: 106150518
ATH: AT1G47290(3BETAHSD/D1) AT2G26260(3BETAHSD/D2) AT2G43420
ALY: ARALYDRAFT_473882(AT3BETAHSD/D1) ARALYDRAFT_481483(AT3BETAHSD/D2) ARALYDRAFT_483452
LJA: Lj0g3v0192789.1(Lj0g3v0192789.1) Lj2g3v0856600.1(Lj2g3v0856600.1) Lj3g3v3325980.1(Lj3g3v3325980.1)
FVE: 101292864
DOSA: Os03t0404800-01(Os03g0404800) Os03t0405000-01(Os03g0405000) Os09t0516500-00(Os09g0516500)
ATS: 109751859(LOC109751859) 109759047(LOC109759047) 109759249(LOC109759249) 109776475(LOC109776475) 109780969(LOC109780969) 109782739(LOC109782739)
PPP: 112282407
CRE: CHLREDRAFT_58501(BHSD1)
MNG: MNEG_5826
APRO: F751_0534
SCE: YGL001C(ERG26)
ERC: Ecym_6178
KMX: KLMA_40026(ERG26)
NCS: NCAS_0A05210(NCAS0A05210)
NDI: NDAI_0K02600(NDAI0K02600)
TPF: TPHA_0K01550(TPHA0K01550)
TBL: TBLA_0E01630(TBLA0E01630)
TDL: TDEL_0F02190(TDEL0F02190)
KAF: KAFR_0F03320(KAFR0F03320)
PIC: PICST_71224(ERG26)
CAL: CAALFM_C406270CA(ERG26)
CDU: CD36_45790(ERG26)
CAUR: QG37_02890
SLB: AWJ20_2805(ERG26)
NCR: NCU02693
NTE: NEUTE1DRAFT119017(NEUTE1DRAFT_119017)
CMT: CCM_07037
MBE: MBM_00113
ANG: ANI_1_470134(An15g03090)
PBL: PAAG_11343(PAAG_01699)
PTE: PTT_14047
CNE: CNJ00460
CNB: CNBJ3060
ABP: AGABI1DRAFT113991(AGABI1DRAFT_113991)
ABV: AGABI2DRAFT193828(AGABI2DRAFT_193828)
MGL: MGL_3391
SPAR: SPRG_01499
 » show all
Taxonomy
Reference
1  [PMID:7430141]
  Authors
Brady DR, Crowder RD, Hayes WJ.
  Title
Mixed function oxidases in sterol metabolism. Source of reducing equivalents.
  Journal
J Biol Chem 255:10624-9 (1980)
Reference
2  [PMID:4401584]
  Authors
Rahimtula AD, Gaylor JL.
  Title
Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase.
  Journal
J Biol Chem 247:9-15 (1972)
Reference
3  [PMID:9811880]
  Authors
Gachotte D, Barbuch R, Gaylor J, Nickel E, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis.
  Journal
Proc Natl Acad Sci U S A 95:13794-9 (1998)
DOI:10.1073/pnas.95.23.13794
  Sequence
[sce:YGL001C]
Reference
4  [PMID:14506130]
  Authors
Caldas H, Herman GE
  Title
NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets.
  Journal
Hum Mol Genet 12:2981-91 (2003)
DOI:10.1093/hmg/ddg321
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.170
IUBMB Enzyme Nomenclature: 1.1.1.170
ExPASy - ENZYME nomenclature database: 1.1.1.170
BRENDA, the Enzyme Database: 1.1.1.170
CAS: 71822-23-6

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