KEGG   ENZYME: 1.1.1.178Help
Entry
EC 1.1.1.178                Enzyme                                 

Name
3-hydroxy-2-methylbutyryl-CoA dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxy-butyryl CoA dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ = 2-methylacetoacetyl-CoA + NADH + H+ [RN:R04203]
Reaction(KEGG)
Substrate
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA [CPD:C04405];
NAD+ [CPD:C00003]
Product
2-methylacetoacetyl-CoA [CPD:C03344];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
History
EC 1.1.1.178 created 1981
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K08683  3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
Genes
HSA: 3028(HSD17B10)
PTR: 465649(HSD17B10)
PPS: 100971848(HSD17B10)
GGO: 101130538 101131140(HSD17B10)
PON: 100459385(HSD17B10)
NLE: 100594310(HSD17B10)
MCC: 700018(HSD17B10)
MCF: 102123916(HSD17B10)
CSAB: 103232017(HSD17B10)
RRO: 104663370(HSD17B10)
RBB: 108520302(HSD17B10)
CJC: 100402832(HSD17B10)
SBQ: 101039788(HSD17B10)
MMU: 15108(Hsd17b10)
RNO: 63864(Hsd17b10)
CGE: 100757689(Hsd17b10)
NGI: 103747316(Hsd17b10)
HGL: 101712281(Hsd17b10)
CCAN: 109702046(Hsd17b10)
OCU: 100342235(HSD17B10)
TUP: 102491700(HSD17B10)
CFA: 480930(HSD17B10)
AML: 100483379(HSD17B10)
UMR: 103675231(HSD17B10)
ORO: 101369544(HSD17B10)
FCA: 101090672(HSD17B10)
PTG: 102956982(HSD17B10)
AJU: 106985377(HSD17B10)
BTA: 281809(HSD17B10)
BOM: 102284367(HSD17B10)
BIU: 109555307(HSD17B10)
PHD: 102334835(HSD17B10)
CHX: 102182021(HSD17B10)
OAS: 101119880(HSD17B10)
SSC: 100524293(HSD17B10)
CFR: 102504376(HSD17B10)
CDK: 105096695(HSD17B10)
BACU: 103010500(HSD17B10)
LVE: 103085758(HSD17B10)
OOR: 101287041(HSD17B10)
ECB: 100060335(HSD17B10)
EPZ: 103542953(HSD17B10)
EAI: 106822166(HSD17B10)
MYB: 102241897 102254109(HSD17B10)
MYD: 102751672(HSD17B10)
HAI: 109396389(HSD17B10)
RSS: 109438824(HSD17B10)
PALE: 102882756(HSD17B10)
LAV: 100676457(HSD17B10)
TMU: 101360197
MDO: 100019657(HSD17B10)
SHR: 100918332(HSD17B10)
OAA: 100081790(HSD17B10)
GGA: 425758(HSD17B10)
MGP: 100540780(HSD17B10)
APLA: 101797626(HSD17B10)
TGU: 100228698(HSD17B10)
FAB: 101812085(HSD17B10)
PHI: 102108549(HSD17B10)
PMAJ: 107199346(HSD17B10)
FPG: 101922240(HSD17B10)
FCH: 102045831(HSD17B10)
AAM: 106497495(HSD17B10)
ASN: 102377997(HSD17B10)
AMJ: 102559608(HSD17B10)
PSS: 102446152(HSD17B10)
CMY: 102935413(HSD17B10)
CPIC: 101946623(HSD17B10)
ACS: 100566347(hsd17b10)
PVT: 110089193(HSD17B10)
PBI: 103051793(HSD17B10)
GJA: 107117365(HSD17B10)
XLA: 108699982 446903(hsd17b10.L)
XTR: 549265(hsd17b10)
NPR: 108797529(HSD17B10)
DRE: 450078(hsd17b10)
SANH: 107656989 107672063(hsd17b10)
IPU: 100528090(hsd17b10)
AMEX: 103024621(hsd17b10)
TRU: 101074613(hsd17b10)
LCO: 104928358(hsd17b10)
MZE: 101486814(hsd17b10)
OLA: 101170516(hsd17b10)
XMA: 102219644(hsd17b10) 111608152
PRET: 103467892(hsd17b10)
NFU: 107390369(hsd17b10)
CSEM: 103385214(hsd17b10)
LCF: 108875474(hsd17b10)
HCQ: 109523116(hsd17b10)
BPEC: 110175804(hsd17b10)
SASA: 100196585(hsd17b10)
ELS: 105013512(hsd17b10)
SFM: 108918316(hsd17b10)
LCM: 102359593(HSD17B10)
CIN: 100180343
SPU: 579135
APLC: 110974895
SKO: 100374978
DME: Dmel_CG7113(scu)
DSI: Dsimw501_GD17383(Dsim_GD17383)
MDE: 101893864
AAG: 5571804
SOC: 105205705
PBAR: 105431577
HST: 105184127
CFO: 105248305
LHU: 105674362
PGC: 109854144
NVI: 100114736
TCA: 660648
NVL: 108566047
API: 100164493
DNX: 107170240
ZNE: 110836005
FCD: 110856173
TUT: 107360644
CEL: CELE_F01G4.2(ard-1)
CBR: CBG06017(Cbr-ard-1)
BMY: Bm1_06360
MYI: 110451007
OBI: 106870550
LAK: 106166979
SHX: MS3_09879
EGL: EGR_00218
EPA: 110234808
HMG: 100210676
AQU: 100642054
TPS: THAPS_263178(HCD1)
SPAR: SPRG_04958
 » show all
Taxonomy
Reference
1  [PMID:4150713]
  Authors
Conrad RS, Massey LK, Sokatch JR.
  Title
D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida.
  Journal
J Bacteriol 118:103-11 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.178
IUBMB Enzyme Nomenclature: 1.1.1.178
ExPASy - ENZYME nomenclature database: 1.1.1.178
BRENDA, the Enzyme Database: 1.1.1.178
CAS: 52227-66-4

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