KEGG   ENZYME: 1.1.1.181Help
Entry
EC 1.1.1.181                Enzyme                                 

Name
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase;
3beta-hydroxy-Delta5-C27-steroid oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase
Reaction(IUBMB)
cholest-5-ene-3beta,7alpha-diol + NAD+ = 7alpha-hydroxycholest-4-en-3-one + NADH + H+ [RN:R04263]
Reaction(KEGG)
Substrate
cholest-5-ene-3beta,7alpha-diol [CPD:C03594];
NAD+ [CPD:C00003]
Product
7alpha-hydroxycholest-4-en-3-one [CPD:C05455];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Highly specific for 3beta-hydroxy-C27-steroids with Delta5-double bond.
History
EC 1.1.1.181 created 1983
Pathway
ec00120  Primary bile acid biosynthesis
ec01100  Metabolic pathways
Orthology
K12408  cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
Genes
HSA: 80270(HSD3B7)
PTR: 454059(HSD3B7)
PPS: 100986476(HSD3B7)
GGO: 101148659(HSD3B7)
PON: 100460204(HSD3B7)
NLE: 105739386(HSD3B7)
MCC: 714136(HSD3B7)
MCF: 102133533(HSD3B7)
CSAB: 103231160(HSD3B7)
RRO: 104661560(HSD3B7)
RBB: 108530070(HSD3B7)
CJC: 100385140(HSD3B7)
SBQ: 101043229(HSD3B7)
MMU: 101502(Hsd3b7)
RNO: 246211(Hsd3b7)
CGE: 100754260(Hsd3b7)
NGI: 103726335(Hsd3b7)
HGL: 101708818(Hsd3b7)
CCAN: 109682434(Hsd3b7)
OCU: 100353878(HSD3B7)
TUP: 102492683(HSD3B7)
CFA: 489917(HSD3B7)
AML: 100482450(HSD3B7)
UMR: 103657879(HSD3B7)
ORO: 101377282(HSD3B7)
FCA: 101090824(HSD3B7)
PTG: 102962469(HSD3B7)
AJU: 106979112(HSD3B7)
BTA: 540229(HSD3B7)
BOM: 102274613(HSD3B7)
BIU: 109578512(HSD3B7)
PHD: 102325068(HSD3B7)
CHX: 102170750(HSD3B7)
OAS: 101105716(HSD3B7)
SSC: 100525281(HSD3B7)
CFR: 102516280(HSD3B7)
CDK: 105102720(HSD3B7)
BACU: 102999563(HSD3B7)
LVE: 103079291(HSD3B7)
OOR: 101283577(HSD3B7)
ECB: 100063491(HSD3B7)
EPZ: 103547271(HSD3B7)
EAI: 106831895(HSD3B7)
MYB: 102253555(HSD3B7)
MYD: 102773587(HSD3B7)
HAI: 109374191(HSD3B7)
RSS: 109437787(HSD3B7)
PALE: 102884924(HSD3B7)
LAV: 100660226(HSD3B7)
TMU: 101357159
MDO: 100018964(HSD3B7)
SHR: 100929800(HSD3B7)
OAA: 100086824(HSD3B7)
GGA: 417505(HSD3B7)
MGP: 100542495
CJO: 107322719
APLA: 101794290(HSD3B7)
ACYG: 106041408
GFR: 102044144
FAB: 101816782(HSD3B7)
PHI: 102108187
CCW: 104691231(HSD3B7)
FPG: 101910304
FCH: 102053118
CLV: 102094713(HSD3B7)
EGZ: 104131788
AAM: 106497335
ASN: 102370034(HSD3B7) 106722879
PSS: 102456594 102460382(HSD3B7)
CMY: 102936770(HSD3B7) 102944939
ACS: 100555869(hsd3b7)
PVT: 110086394(HSD3B7)
PBI: 103058949(HSD3B7)
GJA: 107106647(HSD3B7)
XLA: 108707682 431878 444015(hsd3b7.S)
XTR: 100145626(hsd3b7) 100494546
NPR: 108799016(HSD3B7) 108801722
DRE: 327462(hsd3b7)
IPU: 108280431(hsd3b7)
AMEX: 103040338(hsd3b7) 111188476
TRU: 101071654(hsd3b7)
LCO: 104930228(hsd3b7)
NCC: 104943711(hsd3b7)
XMA: 102234415(hsd3b7)
PRET: 103468932(hsd3b7)
NFU: 107378516(hsd3b7)
CSEM: 103392669(hsd3b7)
LCF: 108880630(hsd3b7)
HCQ: 109509468 109531629(hsd3b7)
SASA: 106601563 106601564(hsd3b7)
ELS: 105012969(hsd3b7)
LCM: 102350807(HSD3B7) 102356171
SKO: 100377099
TSP: Tsp_09898
LAK: 106170818
 » show all
Taxonomy
Reference
1  [PMID:6937465]
  Authors
Wikvall K.
  Title
Purification and properties of a 3 beta-hydroxy-delta 5-C27-steroid oxidoreductase from rabbit liver microsomes.
  Journal
J Biol Chem 256:3376-80 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.181
IUBMB Enzyme Nomenclature: 1.1.1.181
ExPASy - ENZYME nomenclature database: 1.1.1.181
BRENDA, the Enzyme Database: 1.1.1.181
CAS: 56626-16-5

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