KEGG   ENZYME: 1.1.1.183Help
Entry
EC 1.1.1.183                Enzyme                                 

Name
geraniol dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
geraniol:NADP+ oxidoreductase
Reaction(IUBMB)
geraniol + NADP+ = geranial + NADPH + H+ [RN:R03581]
Reaction(KEGG)
Substrate
geraniol [CPD:C01500];
NADP+ [CPD:C00006]
Product
geranial [CPD:C01499];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly on farnesol but not on nerol. The enzyme produces a mixture known as citral, which includes geranial and neral. It is still not known whether neral is produced directly by the enzyme, or by isomerization of geranial.
History
EC 1.1.1.183 created 1983
Pathway
ec00281  Geraniol degradation
ec01130  Biosynthesis of antibiotics
Reference
1
  Authors
Potty, V.H. and Bruemmer, J.H.
  Title
Oxidation of geraniol by an enzyme system from orange.
  Journal
Phytochemistry 9:1001-1007 (1970)
Reference
2  [PMID:11743782]
  Authors
Sekiwa-Iijima Y, Aizawa Y, Kubota K
  Title
Geraniol dehydrogenase activity related to aroma formation in ginger (Zingiber officinale Roscoe).
  Journal
J Agric Food Chem 49:5902-6 (2001)
DOI:10.1021/jf0102970
Reference
3  [PMID:21636906]
  Authors
Saito Y, Ito S, Koltunow AM, Sakai H
  Title
Crystallization and preliminary X-ray analysis of geraniol dehydrogenase from Backhousia citriodora (lemon myrtle).
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 67:665-7 (2011)
DOI:10.1107/S1744309111006920
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.183
IUBMB Enzyme Nomenclature: 1.1.1.183
ExPASy - ENZYME nomenclature database: 1.1.1.183
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.183
BRENDA, the Enzyme Database: 1.1.1.183
CAS: 56802-96-1

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