KEGG   ENZYME: 1.1.1.184Help
Entry
EC 1.1.1.184                Enzyme                                 

Name
carbonyl reductase (NADPH);
aldehyde reductase 1;
prostaglandin 9-ketoreductase;
xenobiotic ketone reductase;
NADPH-dependent carbonyl reductase;
ALR3;
carbonyl reductase;
nonspecific NADPH-dependent carbonyl reductase;
carbonyl reductase (NADPH2)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
secondary-alcohol:NADP+ oxidoreductase
Reaction(IUBMB)
R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+ [RN:R03557]
Reaction(KEGG)
Substrate
R-CHOH-R' [CPD:C01612];
NADP+ [CPD:C00006]
Product
R-CO-R' [CPD:C01450];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin and prostaglandins E and F, reducing them to the corresponding alcohol. Si-specific with respect to NADPH [cf. EC 1.1.1.2 alcohol dehydrogenase (NADP+)].
History
EC 1.1.1.184 created 1983
Pathway
ec00590  Arachidonic acid metabolism
ec00790  Folate biosynthesis
ec00980  Metabolism of xenobiotics by cytochrome P450
ec01100  Metabolic pathways
Orthology
K00079  carbonyl reductase 1
K00081  carbonyl reductase 2
K00084  carbonyl reductase 3
Genes
HSA: 873(CBR1) 874(CBR3)
PTR: 458533(CBR3) 473983(CBR1)
PPS: 100982905(CBR3) 100984486(CBR1)
GGO: 101128365(CBR1) 101128728(CBR3)
PON: 100172097(CBR1) 100452311(CBR3)
NLE: 100595150(CBR1) 100595496(CBR3)
MCC: 695769(CBR3) 699655(CBR1)
MCF: 102140082(CBR3) 102141127(CBR1)
CSAB: 103218526(CBR1) 103218549(CBR3)
RRO: 104679833(CBR3) 104680046(CBR1)
RBB: 108536876(CBR1) 108536877(CBR3)
CJC: 100385429(CBR1) 100386510(CBR3)
SBQ: 101047149 101053953(CBR1)
MMU: 109857(Cbr3) 12408(Cbr1) 12409(Cbr2)
RNO: 102556347 29224(Cbr1) 304078(Cbr3) 688320 688321
NGI: 103730087 103736427(Cbr3) 103736428(Cbr1)
BTA: 510180(MGC127133) 515946(CBR1) 516036(CBR3) 782391(DCXR)
SSC: 100512990(CBR3) 100622246 396780(CBR2) 397143(CBR1)
CFR: 102513911(CBR1) 102521504(CBR3)
LVE: 103078961 103084396(CBR3) 103084663(CBR1)
OOR: 101271194 101289691(CBR1) 101289932(CBR3)
MYD: 102770622(CBR3) 102773942(CBR1)
OAA: 100081857(CBR1)
GGA: 418512(CBR1)
MGP: 100550018(CBR1)
CJO: 107323279
APLA: 101794661(CBR1)
ACYG: 106036138
TGU: 100222525(CBR1)
GFR: 102043656(CBR1)
FAB: 101809650 101821429(CBR1)
PHI: 102114609(CBR1)
PMAJ: 107211649
CCAE: 111928724
CCW: 104696752
FPG: 101915985(CBR1)
FCH: 102057061(CBR1)
CLV: 102094554
EGZ: 104128238
AAM: 106494985
ASN: 102386516
AMJ: 102575087(CBR1)
PSS: 102454231
CPIC: 101937374(CBR1)
PBI: 103066276
GJA: 107119801
XTR: 100145008(cbr3) 101735101 496612(cbr1)
DRE: 337696(cbr1l) 373866(cbr1)
CCAR: 109096114(cbr1)
IPU: 108258607(cbr1) 108279390
TRU: 101070504(cbr1)
LCO: 104925597(cbr1)
NCC: 104949102
OLA: 100125494(cbr1)
XMA: 102228388(cbr1) 102228648
NFU: 107376130 107376131(cbr1)
CSEM: 103387805(cbr1)
LCF: 108872922(cbr1)
SDU: 111223859(cbr1)
MALB: 109963832(cbr1)
ELS: 105010857 109614572(cbr1)
LCM: 102349061 102367136(CBR1)
CIN: 100182286
AME: 551072
BIM: 100747164
BTER: 100643942
SOC: 105207948
PBAR: 105424036
HST: 105186587
DQU: 106748457
CFO: 105250549
LHU: 105676624
PGC: 109853439
PCF: 106788977
TCA: 661972
NVL: 108565934
API: 103310702
DNX: 107164342
CLEC: 106664003
ZNE: 110840714
TUT: 107369493
BMY: Bm1_44405
LAK: 106157857
HMG: 100200320
AQU: 100637791
CRB: 17876819
CSAT: 104761093
THJ: 104825040
VRA: 106765992
VAR: 108337975
CAM: 101507622
ADU: 107458870
AIP: 107612497
LANG: 109362223
FVE: 105351700
MDM: 103420529
PXB: 103931301
ZJU: 107406898
CMO: 103488873
RCU: 8286374
SOT: 102587809
NTO: 104099524
OEU: 111372333
LSV: 111896716
DCR: 108220469
NNU: 104598224
PDA: 103716007
EGU: 105051634
DCT: 110095551
AOF: 109830212
PTE: PTT_09714
SMIN: v1.2.027692.t1(symbB.v1.2.027692.t1)
SPAR: SPRG_20516
 » show all
Taxonomy
Reference
1  [PMID:31888]
  Authors
Ahmed NK, Felsted RL, Bachur NR.
  Title
Heterogeneity of anthracycline antibiotic carbonyl reductases in mammalian livers.
  Journal
Biochem Pharmacol 27:2713-9 (1978)
DOI:10.1016/0006-2952(78)90047-3
Reference
2  [PMID:666816]
  Authors
Lin YM, Jarabak J.
  Title
Isolation of two proteins with 9-ketoprostaglandin reductase and NADP-linked 15-hydroxyprostaglandin dehydrogenase activities and studies on their inhibition.
  Journal
Biochem Biophys Res Commun 81:1227-34 (1978)
DOI:10.1016/0006-291X(78)91267-6
Reference
3  [PMID:7005231]
  Authors
Wermuth B.
  Title
Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase.
  Journal
J Biol Chem 256:1206-13 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.184
IUBMB Enzyme Nomenclature: 1.1.1.184
ExPASy - ENZYME nomenclature database: 1.1.1.184
BRENDA, the Enzyme Database: 1.1.1.184
CAS: 89700-36-7

KEGG   ENZYME: 1.1.1.189Help
Entry
EC 1.1.1.189                Enzyme                                 

Name
prostaglandin-E2 9-reductase;
PGE2-9-OR;
reductase, 15-hydroxy-9-oxoprostaglandin;
9-keto-prostaglandin E2 reductase;
9-ketoprostaglandin reductase;
PGE-9-ketoreductase;
PGE2 9-oxoreductase;
PGE2-9-ketoreductase;
prostaglandin 9-ketoreductase;
prostaglandin E 9-ketoreductase;
prostaglandin E2-9-oxoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+ [RN:R02581]
Reaction(KEGG)
Substrate
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate [CPD:C00639];
NADP+ [CPD:C00006]
Product
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate [CPD:C00584];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces prostaglandin E2 to prostaglandin F2alpha. A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds. May be identical with EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+).
History
EC 1.1.1.189 created 1984, modified 1989
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K00079  carbonyl reductase 1
Genes
HSA: 873(CBR1)
PTR: 473983(CBR1)
PPS: 100984486(CBR1)
GGO: 101128365(CBR1)
PON: 100172097(CBR1)
NLE: 100595150(CBR1)
MCC: 699655(CBR1)
MCF: 102141127(CBR1)
CSAB: 103218526(CBR1)
RRO: 104680046(CBR1)
RBB: 108536876(CBR1)
CJC: 100385429(CBR1)
SBQ: 101053953(CBR1)
MMU: 12408(Cbr1)
RNO: 102556347 29224(Cbr1)
NGI: 103736428(Cbr1)
TUP: 102493488(CBR1)
AML: 100463727 100482421(CBR1)
BTA: 510180(MGC127133) 515946(CBR1)
SSC: 100622246 397143(CBR1)
CFR: 102513911(CBR1)
CDK: 105089844
BACU: 103007396
LVE: 103084663(CBR1)
OOR: 101289691(CBR1)
MYD: 102773942(CBR1)
HAI: 109391219
RSS: 109446658
PALE: 102891228
SHR: 100920969
OAA: 100081857(CBR1)
GGA: 418512(CBR1)
MGP: 100550018(CBR1)
CJO: 107323279
APLA: 101794661(CBR1)
ACYG: 106036138
TGU: 100222525(CBR1)
GFR: 102043656(CBR1)
FAB: 101809650 101821429(CBR1)
PHI: 102114609(CBR1)
PMAJ: 107211649
CCAE: 111928724
CCW: 104696752
FPG: 101915985(CBR1)
FCH: 102057061(CBR1)
CLV: 102094554
EGZ: 104128238
AAM: 106494985
ASN: 102386516
AMJ: 102575087(CBR1)
PSS: 102454231
CPIC: 101937374(CBR1)
PBI: 103066276
GJA: 107119801
XTR: 100145008(cbr3) 101735101 496612(cbr1)
DRE: 337696(cbr1l) 373866(cbr1)
CCAR: 109096114(cbr1)
IPU: 108258607(cbr1) 108279390
TRU: 101070504(cbr1)
LCO: 104925597(cbr1)
NCC: 104949102
OLA: 100125494(cbr1)
XMA: 102228388(cbr1) 102228648
NFU: 107376130 107376131(cbr1)
CSEM: 103387805(cbr1)
LCF: 108872922(cbr1)
SDU: 111223859(cbr1)
MALB: 109963832(cbr1)
ELS: 105010857 109614572(cbr1)
LCM: 102349061 102367136(CBR1)
CIN: 100182286
AME: 551072
BIM: 100747164
BTER: 100643942
SOC: 105207948
PBAR: 105424036
HST: 105186587
DQU: 106748457
CFO: 105250549
LHU: 105676624
PGC: 109853439
PCF: 106788977
TCA: 661972
NVL: 108565934
API: 103310702
DNX: 107164342
CLEC: 106664003
ZNE: 110840714
TUT: 107369493
BMY: Bm1_44405
OBI: 106869220
LAK: 106157857
HMG: 100200320
AQU: 100637791
CRB: 17876819
CSAT: 104761093
THJ: 104825040
VRA: 106765992
VAR: 108337975
CAM: 101507622
ADU: 107458870
AIP: 107612497
LANG: 109362223
FVE: 105351700
MDM: 103420529
PXB: 103931301
ZJU: 107406898
CMO: 103488873
RCU: 8286374
SOT: 102587809
NTO: 104099524
OEU: 111372333
LSV: 111896716
DCR: 108220469
NNU: 104598224
PDA: 103716007
EGU: 105051634
DCT: 110095551
AOF: 109830212
PTE: PTT_09714
SMIN: v1.2.027692.t1(symbB.v1.2.027692.t1)
SPAR: SPRG_20516
 » show all
Taxonomy
Reference
1  [PMID:166995]
  Authors
Lee SC, Levine L.
  Title
Purification and regulatory properties of chicken heart prostaglandin E 9-ketoreductase.
  Journal
J Biol Chem 250:4549-55 (1975)
Reference
2  [PMID:6586494]
  Authors
Schlegel W, Kruger S, Korte K.
  Title
Purification of prostaglandin E2-9-oxoreductase from human decidua vera.
  Journal
FEBS Lett 171:141-4 (1984)
DOI:10.1016/0014-5793(84)80475-5
Reference
3  [PMID:7132747]
  Authors
Tai HH, Yuan B.
  Title
Purification and assay of 9-hydroxyprostaglandin dehydrogenase from rat kidney.
  Journal
Methods Enzymol 86:113-7 (1982)
Reference
4  [PMID:3901124]
  Authors
Watkins JD, Jarabak J.
  Title
The effect of NaCl intake on 9-ketoprostaglandin reductase activity in the rabbit kidney.
  Journal
Prostaglandins 30:335-49 (1985)
DOI:10.1016/0090-6980(85)90196-0
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.189
IUBMB Enzyme Nomenclature: 1.1.1.189
ExPASy - ENZYME nomenclature database: 1.1.1.189
BRENDA, the Enzyme Database: 1.1.1.189
CAS: 42613-35-4

KEGG   ENZYME: 1.1.1.197Help
Entry
EC 1.1.1.197                Enzyme                                 

Name
15-hydroxyprostaglandin dehydrogenase (NADP+);
NADP-dependent 15-hydroxyprostaglandin dehydrogenase;
NADP-linked 15-hydroxyprostaglandin dehydrogenase;
NADP-specific 15-hydroxyprostaglandin dehydrogenase;
type II 15-hydroxyprostaglandin dehydrogenase;
15-hydroxyprostaglandin dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase
Reaction(IUBMB)
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+ [RN:R04552]
Reaction(KEGG)
Substrate
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate [CPD:C04741];
NADP+ [CPD:C00006]
Product
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate [CPD:C04654];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.
History
EC 1.1.1.197 created 1984
Orthology
K00079  carbonyl reductase 1
Genes
HSA: 873(CBR1)
PTR: 473983(CBR1)
PPS: 100984486(CBR1)
GGO: 101128365(CBR1)
PON: 100172097(CBR1)
NLE: 100595150(CBR1)
MCC: 699655(CBR1)
MCF: 102141127(CBR1)
CSAB: 103218526(CBR1)
RRO: 104680046(CBR1)
RBB: 108536876(CBR1)
CJC: 100385429(CBR1)
SBQ: 101053953(CBR1)
MMU: 12408(Cbr1)
RNO: 102556347 29224(Cbr1)
NGI: 103736428(Cbr1)
TUP: 102493488(CBR1)
AML: 100463727 100482421(CBR1)
BTA: 510180(MGC127133) 515946(CBR1)
SSC: 100622246 397143(CBR1)
CFR: 102513911(CBR1)
CDK: 105089844
BACU: 103007396
LVE: 103084663(CBR1)
OOR: 101289691(CBR1)
MYD: 102773942(CBR1)
HAI: 109391219
RSS: 109446658
PALE: 102891228
SHR: 100920969
OAA: 100081857(CBR1)
GGA: 418512(CBR1)
MGP: 100550018(CBR1)
CJO: 107323279
APLA: 101794661(CBR1)
ACYG: 106036138
TGU: 100222525(CBR1)
GFR: 102043656(CBR1)
FAB: 101809650 101821429(CBR1)
PHI: 102114609(CBR1)
PMAJ: 107211649
CCAE: 111928724
CCW: 104696752
FPG: 101915985(CBR1)
FCH: 102057061(CBR1)
CLV: 102094554
EGZ: 104128238
AAM: 106494985
ASN: 102386516
AMJ: 102575087(CBR1)
PSS: 102454231
CPIC: 101937374(CBR1)
PBI: 103066276
GJA: 107119801
XTR: 100145008(cbr3) 101735101 496612(cbr1)
DRE: 337696(cbr1l) 373866(cbr1)
CCAR: 109096114(cbr1)
IPU: 108258607(cbr1) 108279390
TRU: 101070504(cbr1)
LCO: 104925597(cbr1)
NCC: 104949102
OLA: 100125494(cbr1)
XMA: 102228388(cbr1) 102228648
NFU: 107376130 107376131(cbr1)
CSEM: 103387805(cbr1)
LCF: 108872922(cbr1)
SDU: 111223859(cbr1)
MALB: 109963832(cbr1)
ELS: 105010857 109614572(cbr1)
LCM: 102349061 102367136(CBR1)
CIN: 100182286
AME: 551072
BIM: 100747164
BTER: 100643942
SOC: 105207948
PBAR: 105424036
HST: 105186587
DQU: 106748457
CFO: 105250549
LHU: 105676624
PGC: 109853439
PCF: 106788977
TCA: 661972
NVL: 108565934
API: 103310702
DNX: 107164342
CLEC: 106664003
ZNE: 110840714
TUT: 107369493
BMY: Bm1_44405
OBI: 106869220
LAK: 106157857
HMG: 100200320
AQU: 100637791
CRB: 17876819
CSAT: 104761093
THJ: 104825040
VRA: 106765992
VAR: 108337975
CAM: 101507622
ADU: 107458870
AIP: 107612497
LANG: 109362223
FVE: 105351700
MDM: 103420529
PXB: 103931301
ZJU: 107406898
CMO: 103488873
RCU: 8286374
SOT: 102587809
NTO: 104099524
OEU: 111372333
LSV: 111896716
DCR: 108220469
NNU: 104598224
PDA: 103716007
EGU: 105051634
DCT: 110095551
AOF: 109830212
PTE: PTT_09714
SMIN: v1.2.027692.t1(symbB.v1.2.027692.t1)
SPAR: SPRG_20516
 » show all
Taxonomy
Reference
1  [PMID:234431]
  Authors
Lee SC, Levine L.
  Title
Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.
  Journal
J Biol Chem 250:548-52 (1975)
Reference
2  [PMID:803247]
  Authors
Lee SC, Pong SS, Katzen D, Wu KY, Levine L.
  Title
Distribution of prostaglandin E 9-KETOREDUCTASE AND TYPES I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.
  Journal
Biochemistry 14:142-5 (1975)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.197
IUBMB Enzyme Nomenclature: 1.1.1.197
ExPASy - ENZYME nomenclature database: 1.1.1.197
BRENDA, the Enzyme Database: 1.1.1.197
CAS: 54989-39-8

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