KEGG   ENZYME: 1.1.1.188Help
Entry
EC 1.1.1.188                Enzyme                                 

Name
prostaglandin-F synthase;
prostaglandin-D2 11-reductase;
reductase, 15-hydroxy-11-oxoprostaglandin;
PGD2 11-ketoreductase;
PGF2alpha synthetase;
prostaglandin 11-ketoreductase;
prostaglandin D2-ketoreductase;
prostaglandin F synthase;
prostaglandin F synthetase;
synthetase, prostaglandin F2alpha;
PGF synthetase;
NADPH-dependent prostaglandin D2 11-keto reductase;
prostaglandin 11-keto reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ [RN:R02684]
Reaction(KEGG)
R02684;
(other) R02799
Show
Substrate
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate [CPD:C00639];
NADP+ [CPD:C00006]
Product
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD:C00696];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2. Also catalyses the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
History
EC 1.1.1.188 created 1984, modified 1989, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
Orthology
K04119  aldo-keto reductase family 1 member C3
Genes
HSA: 8644(AKR1C3)
PTR: 100612718(AKR1C3)
PPS: 100986388(AKR1C3)
GGO: 101144878
PON: 100174617(AKR1C3)
NLE: 100604844(AKR1C3)
MCC: 711440(AKR1C3)
MCF: 102142023(HSD17B5)
RBB: 108532990
SBQ: 101041594
CFA: 497070(AKR1C3)
FCA: 100510801(AKR1C3)
PTG: 102963188
AJU: 106988139
BTA: 100139386(20ALPHA-HSD) 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884 785762
BOM: 102269337
BIU: 109568087
SSC: 733634(AKR1C1)
LVE: 103069218
ECB: 100070616
MYB: 102255491
MYD: 102751586
TMU: 101342771
OAA: 100085065
PSS: 102446010
PVT: 110088827
XLA: 100049750(LOC100490956.L) 443571(akr1c3.L)
XTR: 105946859 779627(akr1c3)
 » show all
Taxonomy
Reference
1  [PMID:7248318]
  Authors
Reingold DF, Kawasaki A, Needleman P.
  Title
A novel prostaglandin 11-keto reductase found in rabbit liver.
  Journal
Biochim Biophys Acta 659:179-88 (1981)
DOI:10.1016/0005-2744(81)90282-5
Reference
2
  Authors
Watanabe, K., Shimizu, T. and Hayaishi, O.
  Title
Enzymatic conversion of prostaglandin-D2 to prostaglandin-F2alpha in the rat lung.
  Journal
Biochem Int 2:603-610 (1981)
Reference
3  [PMID:3858278]
  Authors
Watanabe K, Yoshida R, Shimizu T, Hayaishi O.
  Title
Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung.
  Journal
J Biol Chem 260:7035-41 (1985)
Reference
4  [PMID:7248317]
  Authors
Wong PY.
  Title
Purification and partial characterization of prostaglandin D2 11-keto reductase in rabbit liver.
  Journal
Biochim Biophys Acta 659:169-78 (1981)
DOI:10.1016/0005-2744(81)90281-3
Reference
5  [PMID:7132748]
  Authors
Wong PY.
  Title
Purification of PGD2 11-ketoreductase from rabbit liver.
  Journal
Methods Enzymol 86:117-25 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.188
IUBMB Enzyme Nomenclature: 1.1.1.188
ExPASy - ENZYME nomenclature database: 1.1.1.188
BRENDA, the Enzyme Database: 1.1.1.188
CAS: 55976-95-9

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