KEGG   ENZYME: 1.1.1.2Help
Entry
EC 1.1.1.2                  Enzyme                                 

Name
alcohol dehydrogenase (NADP+);
aldehyde reductase (NADPH2);
NADP-alcohol dehydrogenase;
NADP+-aldehyde reductase;
NADP+-dependent aldehyde reductase;
NADPH-aldehyde reductase;
NADPH-dependent aldehyde reductase;
nonspecific succinic semialdehyde reductase;
ALR 1;
low-Km aldehyde reductase;
high-Km aldehyde reductase;
alcohol dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
alcohol:NADP+ oxidoreductase
Reaction(IUBMB)
an alcohol + NADP+ = an aldehyde + NADPH + H+ [RN:R07328]
Reaction(KEGG)
Substrate
alcohol [CPD:C00069];
NADP+ [CPD:C00006]
Product
aldehyde [CPD:C00071];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A zinc protein. Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. May be identical with EC 1.1.1.19 (L-glucuronate reductase), EC 1.1.1.33 [mevaldate reductase (NADPH)] and EC 1.1.1.55 [lactaldehyde reductase (NADPH)]. Re-specific with respect to NADPH.
History
EC 1.1.1.2 created 1961
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec00040  Pentose and glucuronate interconversions
ec00561  Glycerolipid metabolism
ec00930  Caprolactam degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
ec01130  Biosynthesis of antibiotics
Orthology
K00002  alcohol dehydrogenase (NADP+)
Genes
HSA: 10327(AKR1A1)
PTR: 741418(AKR1A1)
PPS: 100990701(AKR1A1)
GGO: 101124639(AKR1A1)
PON: 100173796(AKR1A1)
NLE: 100581229(AKR1A1)
MCC: 693380(AKR1A1)
MCF: 102143796(AKR1A1)
CSAB: 103224909(AKR1A1)
RRO: 104662135(AKR1A1)
CJC: 100404430(AKR1A1)
SBQ: 101054314(AKR1A1)
MMU: 58810(Akr1a1)
RNO: 78959(Akr1a1)
CGE: 100689106(Akr1a1)
NGI: 103728426 103737782(Akr1a1)
HGL: 101710959(Akr1a1)
CCAN: 109698640(Akr1a1)
TUP: 102474258(AKR1A1)
CFA: 610537(AKR1A1)
AML: 100466911(AKR1A1)
UMR: 103670772(AKR1A1)
ORO: 101378260(AKR1A1)
FCA: 101091464(AKR1A1)
PTG: 102953655(AKR1A1)
AJU: 106970247(AKR1A1)
BTA: 618607(AKR1A1)
BOM: 102278148(AKR1A1)
BIU: 109556353(AKR1A1)
PHD: 102329994(AKR1A1)
CHX: 102181747(AKR1A1)
OAS: 101121637(AKR1A1)
SSC: 396924(AKR1A1)
CFR: 102508336(AKR1A1)
CDK: 105090867(AKR1A1)
BACU: 103012987(AKR1A1)
LVE: 103076421(AKR1A1)
OOR: 101275575(AKR1A1)
ECB: 100052360(AKR1A1)
EPZ: 103551882(AKR1A1)
EAI: 106826141(AKR1A1)
MYB: 102261432(AKR1A1)
MYD: 102763234(AKR1A1)
HAI: 109375511(AKR1A1)
RSS: 109456895(AKR1A1)
PALE: 102889346(AKR1A1)
MDO: 100024617(AKR1A1)
SHR: 100933920(AKR1A1)
OAA: 100076515(AKR1A1)
GGA: 424599(AKR1A1)
MGP: 100547531(AKR1A1)
CJO: 107317439(AKR1A1)
APLA: 101804381(AKR1A1)
ACYG: 106033070(AKR1A1)
TGU: 100220342(AKR1A1)
GFR: 102039134(AKR1A1)
FAB: 101814677(AKR1A1)
PHI: 102111381(AKR1A1)
PMAJ: 107208007(AKR1A1)
CCAE: 111933109(AKR1A1)
CCW: 104695240(AKR1A1)
FPG: 101914281(AKR1A1)
FCH: 102058485(AKR1A1)
CLV: 102086095(AKR1A1)
EGZ: 104126259(AKR1A1)
AAM: 106485925(AKR1A1)
ASN: 102381941(AKR1A1)
AMJ: 102560934(AKR1A1)
PSS: 102453813(AKR1A1)
CMY: 102932885(AKR1A1)
CPIC: 101951623(AKR1A1)
ACS: 100553683(akr1a1)
PVT: 110073749(AKR1A1)
PBI: 103067202(AKR1A1)
GJA: 107107909(AKR1A1)
XLA: 108715556(akr1a1.S) 444488(akr1a1.L)
XTR: 548891(akr1a1)
NPR: 108802784(AKR1A1)
DRE: 445326(akr1a1a) 799805(akr1a1b)
IPU: 100528626(akr1a1)
AMEX: 103028964(akr1a1)
TRU: 101075563 101077149(akr1a1)
LCO: 104921221 104937447(akr1a1)
NCC: 104947807 104956412(akr1a1)
MZE: 101467748 101476039(akr1a1)
OLA: 101172969(akr1a1) 101175168
XMA: 102234019 102236025(akr1a1)
PRET: 103464015(akr1a1) 103470380
NFU: 107387343(akr1a1) 107393930
KMR: 108234548 108244962(akr1a1)
CSEM: 103398194 103398807(akr1a1)
LCF: 108878174 108878819(akr1a1)
SDU: 111231669 111232002(akr1a1)
HCQ: 109506839(akr1a1) 109514126
BPEC: 110156675 110168991(akr1a1)
MALB: 109965784(akr1a1)
SASA: 106560437(AK1A1) 106580289 106584055(AK1A1)
ELS: 105005908(akr1a1) 105025564
SFM: 108935416(akr1a1) 108938083
CMK: 103176872 103182771(akr1a1)
SPU: 587281
DME: Dmel_CG2767(CG2767)
DSI: Dsimw501_GD19441(Dsim_GD19441)
MDE: 101897237
AAG: 5577411
AEC: 105146772
PBAR: 105428232
NVI: 100116672
BMOR: 101746883
PMAC: 106721698
HAW: 110378598
MYI: 110455981
ADF: 107338307
HMG: 100200051
AQU: 100632875
ATH: AT2G37760(AKR4C8) AT2G37770(ChlAKR) AT2G37790(AKR4C10) AT3G53880(AKR4C11) AT5G01670
LJA: Lj0g3v0100549.1(Lj0g3v0100549.1) Lj0g3v0141139.1(Lj0g3v0141139.1) Lj1g3v2393300.1(Lj1g3v2393300.1) Lj1g3v3443800.1(Lj1g3v3443800.1) Lj3g3v1591680.1(Lj3g3v1591680.1) Lj3g3v3396890.1(Lj3g3v3396890.1) Lj4g3v0473890.1(Lj4g3v0473890.1) Lj4g3v0484310.1(Lj4g3v0484310.1) Lj5g3v0110960.1(Lj5g3v0110960.1)
SPEN: 107030686
CANN: 107842839
OSA: 4327475
DOSA: Os01t0847600-01(Os01g0847600) Os01t0847700-01(Os01g0847700) Os02t0123500-01(Os02g0123500) Os05t0456200-00(Os05g0456200) Os05t0456300-01(Os05g0456300) Os05t0474600-01(Os05g0474600)
ATS: 109742647(LOC109742647) 109745552(LOC109745552) 109748209(LOC109748209) 109751158(LOC109751158) 109751159(LOC109751159) 109751161(LOC109751161) 109751162(LOC109751162) 109751164(LOC109751164) 109751166(LOC109751166) 109760025(LOC109760025) 109760026(LOC109760026) 109768050(LOC109768050) 109786214(LOC109786214)
ZMA: 100194348 100279403(cl25115_1) 100381673(TIDP2673) 100857058(AR3) 103625686 103630432
MNG: MNEG_0815
SCE: YCR105W(ADH7) YMR318C(ADH6)
ERC: Ecym_1093
KMX: KLMA_80339(ADH6)
NCS: NCAS_0C03020(NCAS0C03020) NCAS_0D01220(NCAS0D01220)
NDI: NDAI_0A08470(NDAI0A08470) NDAI_0G04880(NDAI0G04880) NDAI_0H02940(NDAI0H02940) NDAI_0H02950(NDAI0H02950)
TPF: TPHA_0A00140(TPHA0A00140) TPHA_0F02090(TPHA0F02090) TPHA_0J00170(TPHA0J00170)
TBL: TBLA_0A02730(TBLA0A02730) TBLA_0A06640(TBLA0A06640)
TDL: TDEL_0E00230(TDEL0E00230) TDEL_0F02300(TDEL0F02300)
KAF: KAFR_0A08730(KAFR0A08730) KAFR_0B00190(KAFR0B00190) KAFR_0C01550(KAFR0C01550) KAFR_0H03770(KAFR0H03770)
PIC: PICST_29079(ADH4) PICST_31312(ADH5) PICST_45137(ADH7)
SPAA: SPAPADRAFT_63283(ADH6)
CAL: CAALFM_C602480WA(CaO19.5517)
CAUR: QG37_00566
SLB: AWJ20_360(ADH6)
NCR: NCU04823
NTE: NEUTE1DRAFT63362(NEUTE1DRAFT_63362) NEUTE1DRAFT68571(NEUTE1DRAFT_68571)
ANG: ANI_1_358144(An16g02510)
CNE: CNC05140
EHI: EHI_023110(81.t00034) EHI_039190(73.t00013) EHI_198760(34.t00053)
SMIN: v1.2.013976.t1(symbB.v1.2.013976.t1)
TCR: 504425.60
PKC: PKB_2345
CBD: CBUD_1937
CBG: CbuG_1847
NTT: TAO_0889
ABO: ABO_2414(AKR1A1)
ADI: B5T_00396(akr1a1)
AXE: P40_01805
ABU: Abu_0783
DSF: UWK_02985
PSF: PSE_5041
CBEI: LF65_04156
CCE: Ccel_1009
CSS: Cst_c01000(dkgA)
CSD: Clst_0095
RUM: CK1_37840
ROB: CK5_18630
RTO: RTO_08790
PUF: UFO1_2988
SYN: slr0942
SYY: SYNGTS_1828(slr0942)
SYT: SYNGTI_1828(slr0942)
SYS: SYNPCCN_1827(slr0942)
SYQ: SYNPCCP_1827(slr0942)
SYG: sync_0822
CYT: cce_0782
PBAS: SMSP2_00412(dkgA)
SRU: SRU_1267
SRM: SRM_01456
FLM: MY04_0328
GFO: GFO_1874
GFL: GRFL_3606
ZPR: ZPR_1868
CBAT: M666_15795
NDO: DDD_2147
MST: Msp_0967(adh)
MAC: MA_0403
HMA: pNG7101(adh8)
HWA: HQ_1729A
 » show all
Taxonomy
Reference
1  [PMID:4402936]
  Authors
Bosron WF, Prairie RL.
  Title
Triphosphopyridine nucleotide-linked aldehyde reductase. I. Purification and properties of the enzyme from pig kidney cortex.
  Journal
J Biol Chem 247:4480-5 (1972)
Reference
2
  Authors
DeMoss, R.
  Title
Triphosphopyridine nucleotide-specific ethanol dehydrogenase from Leuconostoc mesenteroides.
  Journal
Bacteriol Proc:81 (1953)
Reference
3
  Authors
Reeves, R.E., Montalvo, F.E. and Lushbaugh, T.S.
  Title
Nicotinamide-adenine dinucleotide phosphate-dependent alcohol dehydrogenase. Enzyme from Entamoeba histolytica and some enzyme inhibitors.
  Journal
Int J Biochem 2:55-64 (1971)
Reference
4  [PMID:4393513]
  Authors
Tabakoff B, Erwin VG.
  Title
Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain.
  Journal
J Biol Chem 245:3263-8 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.2
IUBMB Enzyme Nomenclature: 1.1.1.2
ExPASy - ENZYME nomenclature database: 1.1.1.2
BRENDA, the Enzyme Database: 1.1.1.2
CAS: 9028-12-0

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