KEGG   ENZYME: 1.1.1.214Help
Entry
EC 1.1.1.214                Enzyme                                 

Name
2-dehydropantolactone reductase (Si-specific);
2-oxopantoyl lactone reductase;
2-ketopantoyl lactone reductase;
ketopantoyl lactone reductase;
2-dehydropantoyl-lactone reductase (B-specific);
(R)-pantolactone:NADP+ oxidoreductase (B-specific);
2-dehydropantolactone reductase (B-specific)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-pantolactone:NADP+ oxidoreductase (Si-specific)
Reaction(IUBMB)
(R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+ [RN:R03155]
Reaction(KEGG)
Substrate
(R)-pantolactone [CPD:C01012];
NADP+ [CPD:C00006]
Product
2-dehydropantolactone [CPD:C01125];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The Escherichia coli enzyme differs from that from yeast [EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific)], which is specific for the Re-face of NADP+, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase.
History
EC 1.1.1.214 created 1986, modified 1999, modified 2013
Reference
1  [PMID:234966]
  Authors
Wilken DR, King HL Jr, Dyar RE.
  Title
Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate.
  Journal
J Biol Chem 250:2311-4 (1975)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.214
IUBMB Enzyme Nomenclature: 1.1.1.214
ExPASy - ENZYME nomenclature database: 1.1.1.214
BRENDA, the Enzyme Database: 1.1.1.214
CAS: 37211-75-9

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