KEGG   ENZYME: 1.1.1.220Help
Entry
EC 1.1.1.220                Enzyme                                 

Name
6-pyruvoyltetrahydropterin 2'-reductase;
6-pyruvoyltetrahydropterin reductase;
6PPH4(2'-oxo) reductase;
6-pyruvoyl tetrahydropterin (2'-oxo)reductase;
6-pyruvoyl-tetrahydropterin 2'-reductase;
pyruvoyl-tetrahydropterin reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase
Reaction(IUBMB)
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ = 6-pyruvoyltetrahydropterin + NADPH + H+ [RN:R04285]
Reaction(KEGG)
Substrate
6-lactoyl-5,6,7,8-tetrahydropterin [CPD:C04244];
NADP+ [CPD:C00006]
Product
6-pyruvoyltetrahydropterin [CPD:C03684];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Not identical with EC 1.1.1.153 sepiapterin reductase.
History
EC 1.1.1.220 created 1989
Pathway
ec01100  Metabolic pathways
Reference
1  [PMID:4004850]
  Authors
Milstien S, Kaufman S.
  Title
Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates.
  Journal
Biochem Biophys Res Commun 128:1099-107 (1985)
DOI:10.1016/0006-291X(85)91053-8
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.220
IUBMB Enzyme Nomenclature: 1.1.1.220
ExPASy - ENZYME nomenclature database: 1.1.1.220
BRENDA, the Enzyme Database: 1.1.1.220
CAS: 97089-79-7

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