KEGG   ENZYME: 1.1.1.222Help
Entry
EC 1.1.1.222                Enzyme                                 

Name
(R)-4-hydroxyphenyllactate dehydrogenase;
(R)-aromatic lactate dehydrogenase;
D-hydrogenase, D-aryllactate
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:R03337 R03339]
Reaction(KEGG)
Substrate
(R)-3-(4-hydroxyphenyl)lactate [CPD:C03964];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-(4-hydroxyphenyl)pyruvate [CPD:C01179];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on (R)-3-phenyllactate, (R)-3-(indol-3-yl)lactate and (R)-lactate.
History
EC 1.1.1.222 created 1989
Pathway
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
Reference
1
  Authors
Bode, R., Lippoldt, A. and Birnbaum, D.
  Title
Purification and properties of D-aromatic lactate dehydrogenase an enzyme involved in the catabolism of the aromatic amino acids of Candida maltosa.
  Journal
Biochem Physiol Pflanzen 181:189-198 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.222
IUBMB Enzyme Nomenclature: 1.1.1.222
ExPASy - ENZYME nomenclature database: 1.1.1.222
BRENDA, the Enzyme Database: 1.1.1.222
CAS: 101754-02-3

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