KEGG   ENZYME: 1.1.1.237Help
Entry
EC 1.1.1.237                Enzyme                                 

Name
hydroxyphenylpyruvate reductase;
HPPR
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ oxidoreductase
Reaction(IUBMB)
(1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:R03337 R03339];
(2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ = 3-(3,4-dihydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:R03373 R12252]
Reaction(KEGG)
Substrate
(R)-3-(4-hydroxyphenyl)lactate [CPD:C03964];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
(R)-3-(3,4-dihydroxyphenyl)lactate [CPD:C22038]
Product
3-(4-hydroxyphenyl)pyruvate [CPD:C01179];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
3-(3,4-dihydroxyphenyl)pyruvate [CPD:C04045]
Comment
The enzyme participates in the biosynthesis of rosmarinic acid. It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.
History
EC 1.1.1.237 created 1992, modified 2018
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K18606  hydroxyphenylpyruvate reductase
Genes
SOT: 102590277
CANN: 107861824
NTA: 107815351 107815507
NSY: 104246687
NTO: 104089553
INI: 109188277
SIND: 105157644
OEU: 111370835
Taxonomy
Reference
1
  Authors
Petersen, M. and Alfermann, A.W.
  Title
Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase.
  Journal
Z Naturforsch C: Biosci 43:501-504 (1988)
Reference
2  [PMID:15284489]
  Authors
Kim KH, Janiak V, Petersen M
  Title
Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei.
  Journal
Plant Mol Biol 54:311-23 (2004)
DOI:10.1023/B:PLAN.0000036367.03056.b2
  Sequence
Reference
3  [PMID:25918800]
  Authors
Kim YB, Uddina MR, Kim Y, Park CG, Park SU
  Title
Molecular cloning and characterization of tyrosine aminotransferase and hydroxyphenylpyruvate reductase, and rosmarinic acid accumulation in Scutellaria  baicalensis.
  Journal
Nat Prod Commun 9:1311-4 (2014)
Reference
4  [PMID:29329649]
  Authors
Wang GQ, Chen JF, Yi B, Tan HX, Zhang L, Chen WS
  Title
HPPR encodes the hydroxyphenylpyruvate reductase required for the biosynthesis of hydrophilic phenolic acids in Salvia miltiorrhiza.
  Journal
Chin J Nat Med 15:917-927 (2017)
DOI:10.1016/S1875-5364(18)30008-6
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.237
IUBMB Enzyme Nomenclature: 1.1.1.237
ExPASy - ENZYME nomenclature database: 1.1.1.237
BRENDA, the Enzyme Database: 1.1.1.237
CAS: 117590-77-9

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