KEGG   ENZYME: 1.1.1.239Help
Entry
EC 1.1.1.239                Enzyme                                 

Name
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+);
3alpha,17beta-hydroxy steroid dehydrogenase;
3alpha(17beta)-HSD;
17-ketoreductase (ambiguous);
17beta-HSD (ambiguous);
HSD17B6 (gene name);
HSD17B8 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase
Reaction(IUBMB)
testosterone + NAD+ = androstenedione + NADH + H+ [RN:R01836]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NAD+ [CPD:C00003]
Product
androstenedione [CPD:C00280];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on other 17beta-hydroxysteroids and on the 3alpha-hydroxy group of pregnanes and bile acids. Different from EC 1.1.1.50 3alpha-hydroxysteroid dehydrogenase (Si-specific) or EC 1.1.1.213 3alpha-hydroxysteroid dehydrogenase (Re-specific).
History
EC 1.1.1.239 created 1992, modified 2012 (EC 1.1.1.63 created 1965, incorporated 2012)
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K13368  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K13369  17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K13370  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
Genes
HSA: 3294(HSD17B2) 7923(HSD17B8) 8630(HSD17B6)
PTR: 454269(HSD17B2) 746685(HSD17B8)
PPS: 100983435(HSD17B2) 100993294(HSD17B8) 100996145(HSD17B6)
GGO: 101131453(HSD17B2) 101143846(HSD17B8) 101153072(HSD17B6)
PON: 100456547(HSD17B2) 100458219(HSD17B6) 100461538(HSD17B8)
NLE: 100588757(HSD17B2) 100606923(HSD17B6) 100607728(HSD17B8)
MCC: 713549(HSD17B6) 714282(HSD17B2) 718119(HSD17B8)
MCF: 101926544(HSD17B6) 102119721(HSD17B2) 102134563(HSD17B8)
CSAB: 103221677(HSD17B8) 103233373(HSD17B2) 103238543(HSD17B6)
RRO: 104657981(HSD17B8) 104671622(HSD17B2) 104673659(HSD17B6)
RBB: 108516069(HSD17B6) 108521311(HSD17B2) 108540288(HSD17B8)
CJC: 100387390(HSD17B6) 100390710(HSD17B2) 100415565(HSD17B8)
SBQ: 101030366(HSD17B2) 101042328(HSD17B8) 101054253(HSD17B6)
MMU: 14979(H2-Ke6) 15486(Hsd17b2) 27400(Hsd17b6)
RNO: 100362350 286964(Hsd17b6) 361802(Hsd17b8) 79243(Hsd17b2)
CGE: 100751897(Hsd17b2) 100762147(Hsd17b6) 100766230(Hsd17b8)
NGI: 103730224(Hsd17b6) 103739734(Hsd17b8) 103748738(Hsd17b2)
HGL: 101699287(Hsd17b6) 101719685(Hsd17b2) 101726130(Hsd17b8)
OCU: 100353430(HSD17B8) 100358604(HSD17B2)
TUP: 102481564(HSD17B2) 102485005(HSD17B6) 102494154(HSD17B8)
CFA: 481118(HSD17B6) 489690(HSD17B2) 607895(HSD17B8)
AML: 100474694(HSD17B6) 100475452(HSD17B8) 100484508(HSD17B2)
UMR: 103656323(HSD17B6) 103662132(HSD17B2) 103665501(HSD17B8)
ORO: 101368715(HSD17B6) 101374521(HSD17B8) 101379076(HSD17B2)
FCA: 101085592(HSD17B2) 101086309 101088341(HSD17B6) 111556166
PTG: 102958819(HSD17B2) 102968797(HSD17B8) 102971783(HSD17B6)
AJU: 106976117(HSD17B8) 106984011(HSD17B2) 106986922(HSD17B6)
BTA: 515710(HSD17B2) 532422(HSD17B8) 533086(HSD17B6)
BOM: 102278674(HSD17B2) 102283510(HSD17B6) 102286352(HSD17B8)
BIU: 109559345 109572993(HSD17B2) 109576549(HSD17B8)
PHD: 102332625(HSD17B6) 102336871(HSD17B2) 102340413(HSD17B8)
CHX: 102182621(HSD17B2) 102185066(HSD17B6) 102189913(HSD17B8)
OAS: 100913161(HSD17B2) 101105400(HSD17B6) 101116612(HSD17B8)
SSC: 100154372(HSD17B8) 100312973(HSD17B2) 100620470
CFR: 102504651(HSD17B8) 102508382 102514993(HSD17B2)
BACU: 103006419(HSD17B8) 103008169(HSD17B6) 103014202(HSD17B2)
LVE: 103070446(HSD17B2) 103076064(HSD17B6) 103088201(HSD17B8)
OOR: 101278484(HSD17B6) 101284697(HSD17B2) 101287044(HSD17B8)
ECB: 100052840 100052892 100061414(HSD17B8) 100146214(HSD17B2)
EPZ: 103541177(HSD17B8) 103545357 103558215(HSD17B2) 103565330(HSD17B6)
EAI: 106832532(HSD17B2) 106832977(HSD17B6) 106834606(HSD17B8)
MYB: 102252900(HSD17B8) 102260774(HSD17B2)
MYD: 102751454(HSD17B2) 102766664(HSD17B8)
HAI: 109378375(HSD17B2) 109392392(HSD17B8)
RSS: 109450930(HSD17B8) 109452917 109453728(HSD17B2)
PALE: 102882881(HSD17B2) 102883634(HSD17B6) 102889883(HSD17B8)
LAV: 100657790 100673988(HSD17B2) 104847005(HSD17B8)
MDO: 100025234(HSD17B8) 100031815(HSD17B2)
SHR: 100914913(HSD17B8) 100921563(HSD17B2) 100931687
OAA: 100076931(HSD17B2)
GGA: 415807(HSD17B2)
MGP: 100549838(HSD17B2)
CJO: 107319415(HSD17B2)
APLA: 101792379(HSD17B2)
ACYG: 106044875(HSD17B2)
TGU: 100228039(HSD17B2) 100231423
GFR: 102039377(HSD17B2)
FAB: 101810951(HSD17B2)
PHI: 102103079(HSD17B2)
PMAJ: 107209789(HSD17B2)
CCAE: 111934744(HSD17B2)
CCW: 104691825(HSD17B2)
FPG: 101915382(HSD17B2)
FCH: 102048922(HSD17B2)
CLV: 102095570(HSD17B2)
EGZ: 104133743(HSD17B2)
AAM: 106483270(HSD17B2)
AMJ: 102567845 102571332 102574309(HSD17B2) 106737258(HSD17B8)
CMY: 102929636(HSD17B8) 102941631(HSD17B2) 102944543(HSD17B6)
CPIC: 101936532(HSD17B8) 101941193(HSD17B2)
ACS: 100564174(hsd17b6) 103281981(hsd17b8) 103282091
PVT: 110071325 110090097(HSD17B2) 110091148(HSD17B8) 110091362
PBI: 103058540(HSD17B2) 103063622
GJA: 107109831(HSD17B2) 107112070(HSD17B8) 107120904(HSD17B6)
XLA: 108700217(hsd17b8.S) 108714085(hsd17b2.L) 398882(rdh16.L)
XTR: 100135184(rdh16) 100497002(hsd17b2) 549425(hsd17b8)
NPR: 108786564(HSD17B2) 108788379(HSD17B8)
DRE: 449537(hsd17b2) 64815(hsd17b8)
SGH: 107555707 107575377(hsd17b8)
CCAR: 109101603 109101607 109111239(hsd17b8)
IPU: 108275401(Hsd17b2)
AMEX: 103023719(hsd17b8) 103032973(hsd17b2)
TRU: 101066298(hsd17b8) 101071919
LCO: 104933390(hsd17b8) 104938964(hsd17b2)
NCC: 104947942 104963938(hsd17b8)
MZE: 101480373(hsd17b8)
OLA: 101165741(hsd17b8)
XMA: 102218211
PRET: 103472946
NFU: 107392413
KMR: 108242645
CSEM: 103379612(hsd17b2) 103393879(hsd17b8)
SDU: 111233733 111239433(hsd17b8)
BPEC: 110162637(hsd17b2) 110173336(hsd17b8)
MALB: 109952509(hsd17b8) 109969153(hsd17b2)
SASA: 106561531(hsd17b2) 106569955(hsd17b8)
ELS: 105005658(hsd17b8) 105018101(hsd17b2)
SFM: 108935620(hsd17b8)
LCM: 102360275(HSD17B2) 102361445(HSD17B8)
CMK: 103191276
CIN: 100184861
DME: Dmel_CG3603(CG3603)
DSI: Dsimw501_GD16628(Dsim_GD16628)
MDE: 101889816
AAG: 5565619
AME: 552493
BIM: 100741146
BTER: 100645670
SOC: 105202077
AEC: 105146179
ACEP: 105623042
PBAR: 105425524
HST: 105192687
DQU: 106748579
LHU: 105678023
PGC: 109860596
PCF: 106786284
TCA: 103314459
DPA: 109535568
NVL: 108569323
BMOR: 101742305
PRAP: 110999152
HAW: 110379058
API: 100166278
DNX: 107168454
CLEC: 106662223
ZNE: 110831560
TUT: 107362798
CEL: CELE_F09E10.3(dhs-25) CELE_Y39A1A.11(dhs-11)
CBR: CBG18334(Cbr-dhs-11) CBG24510(Cbr-dhs-25)
EPA: 110245465
ADF: 107349767
HMG: 100199027
 » show all
Taxonomy
Reference
1  [PMID:15436478]
  Authors
SWEAT ML, SAMUELS LT, LUMRY R.
  Title
Preparation and characterization of the enzyme which converts testosterone to androstenedione.
  Journal
J Biol Chem 185:75-84 (1950)
Reference
2  [PMID:13781425]
  Authors
VILLEE CA, SPENCER JM.
  Title
Some properties of the pyridine nucleotide-specific 17 beta-hydroxy steroid dehydrogenases of guinea pig liver.
  Journal
J Biol Chem 235:3615-9 (1960)
Reference
3  [PMID:13696735]
  Authors
ENDAHL GL, KOCHAKIAN CD, HAMM D.
  Title
Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver.
  Journal
J Biol Chem 235:2792-6 (1960)
Reference
4  [PMID:2317205]
  Authors
Ohmura M, Hara A, Nakagawa M, Sawada H.
  Title
Demonstration of 3 alpha(17 beta)-hydroxysteroid dehydrogenase distinct from 3 alpha-hydroxysteroid dehydrogenase in hamster liver.
  Journal
Biochem J 266:583-9 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.239
IUBMB Enzyme Nomenclature: 1.1.1.239
ExPASy - ENZYME nomenclature database: 1.1.1.239
BRENDA, the Enzyme Database: 1.1.1.239
CAS: 126469-82-7

DBGET integrated database retrieval system