KEGG   ENZYME: 1.1.1.247Help
Entry
EC 1.1.1.247                Enzyme                                 

Name
codeinone reductase (NADPH)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
codeine:NADP+ oxidoreductase
Reaction(IUBMB)
codeine + NADP+ = codeinone + NADPH + H+ [RN:R05124]
Reaction(KEGG)
R05124;
(other) R03592
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Substrate
codeine [CPD:C06174];
NADP+ [CPD:C00006]
Product
codeinone [CPD:C06171];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reversible reduction of codeinone to codeine, which is a direct precursor of morphine in the opium poppy plant, Papaver somniferum.
History
EC 1.1.1.247 created 1999, modified 2001
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13394  codeinone reductase
Reference
1
  Authors
Lenz, R. and Zenk, M.H.
  Title
Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum.
  Journal
Tetrahedron Lett 36:2449-2452 (1995)
Reference
2  [PMID:7588736]
  Authors
Lenz R, Zenk MH.
  Title
Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures and differentiated plants.
  Journal
Eur J Biochem 233:132-9 (1995)
DOI:10.1111/j.1432-1033.1995.132_1.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.247
IUBMB Enzyme Nomenclature: 1.1.1.247
ExPASy - ENZYME nomenclature database: 1.1.1.247
BRENDA, the Enzyme Database: 1.1.1.247
CAS: 153302-41-1

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